Heat Shock Protein 70 (HSP70) Family in Dengue Virus Infection

  • Rattiyaporn Kanlaya
  • Visith Thongboonkerd
Part of the Heat Shock Proteins book series (HESP, volume 13)


Dengue virus (DENV) infection is a mosquito-borne disease and remains one of the major public health problems worldwide, particularly in tropical and sub-tropical regions. In most cases, the infection causes only mild and self-limiting illness, namely dengue fever (DF). The infection, however, can develop to severe and life-threatening disease known as dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). Recent studies have suggested that host factors, while protect against the invaded virus, can be modulated and utilized by DENV for its survival and propagation within host cells, leading to infection. Heat shock protein 70 (HSP70) family is one of the key components of host machinery for protein homeostasis (proteostasis). Molecular chaperone function of HSP70 family is achieved by cooperative networking of HSP70 family members (HSP70s) and their co-chaperones to regulate ATP-ADP cycling. According to their fundamental importance, HSP70s have been discovered as the host factors hijacked by many viruses, including DENV, for their efficient infection. This chapter provides the current knowledge on how DENV manipulates host HSP70s in multiple stages of the viral life cycle to accomplish the infection. The potential of HSP70s-based antiviral therapeutics is also discussed.


Chaperone Dengue HSP70 Stress response Viral entry Viral replication 



Antibody-dependent enhancement


Antigen presenting cells


Activating transcription factor 6


Binding immunoglobulin protein




Dendritic cells


Dendritic cell-specific ICAM-grabbing non-integrin


Dengue virus


Dengue fever


Dengue hemorrhagic fever


Dengue shock syndrome


Dengue viral host factors




Eukaryotic translation initiation factor 2α


Endoplasmic reticulum


Endoplasmic reticulum protein 44


78 kDa glucose-regulated protein


Heat shock cognate 70


Heat shock protein 70


Inducible HSP70


HSP70 family members


Heat shock 70 kDa protein 5


Intercellular adhesion molecule


Inositol-requiring protein 1


Japanese encephalitis virus


Membrane protein




Non-structural protein


Protein kinase R-like ER kinase


Premembrane protein


RNA-induced silencing complex


RNA interference


Small interfering RNA


Unfolded protein response


Viral overlay protein binding assay


Viral suppressor of RNA silencing


West Nile virus


X-box binding protein 1



This work was supported by Mahidol University research grant and the Thailand Research Fund (IRN60W0004 and IRG5980006).


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Rattiyaporn Kanlaya
    • 1
  • Visith Thongboonkerd
    • 1
  1. 1.Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj HospitalMahidol UniversityBangkokThailand

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