Heat Shock Protein 90: Truly Moonlighting!
Hsp90 is an essential and abundantly expressed molecular chaperone in any living cell. The multiplicity of Hsp90 cellular functions is driven by its interaction with a broad range of partner proteins and thereby establishing itself as a moonlighting molecule. There are newer insights emerging to ascertain the cellular and physiological roles of Hsp90, such as (and not limited to) chromatin remodeling, gene regulation and developmental pathways. Hsp90 has been recognized as an important therapeutic target and has been linked to an increasing number of diseases, including cancer. Development of Hsp90 therapeutic reagents would be valuable research tools towards the maintenance of the proteome in health and disease. This review revisits the expression, structure-function, and clinical significance of the Hsp90 and its forms and reinforces its impact as a disease target.
KeywordsHsp90 Hsp90 diversity HSPC Moonlighting roles Therapeutic candidate
Eggs, germinal vesicle breakdown oocyte
Heat shock proteins
In vitro fertilization- embryo transfer
Liquid chromatography/mass spectrometry
Matrix-assisted laser desorption/ionization time-of-flight/time-of-flight
Premature ovarian failure
Primary ovarian insufficiency
The author would also like to place on record his gratitude to his Ph.D. mentor, the late Dr. Vrinda V Khole from the National Institute for Research in Reproductive Health (ICMR), Mumbai, India who mentored him during the course of his graduate degree. The author thanks the journal Fertility & Sterility for permitting reproduction of one figure from his previously published work [Fig. 12.4. Panel B2 and B5 of Pires ES and Khole VV. 2009: A ‘block’ in the road to fertility: autoantibodies to an immunodominant heat shock protein 90-beta in human ovarian autoimmunity. Fertility & Sterility 92:1395–1409]. Thank you to the journal of Reproductive Biology and Endocrinology for allowing him to reproduce one figure from his earlier work [Fig. 12.1a of Pires ES, Choudhury AK, Idicula-Thomas S, and Khole VV. Anti-Hsp90 autoantibodies in sera of infertile women identify a dominant, conserved epitope EP6 (380–389) of Hsp90 beta protein. Reprod Biol Endocrinol. 2011; 9: 16].
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