Diuretics in Heart Failure

  • Sarat KuppachiEmail author
  • Mony Fraer


Heart failure (HF) is a rapidly growing global pandemic. Despite advances in treatment, morbidity and mortality rates in the post-discharge period after an admission for acute decompensated heart failure (ADHF) remain unacceptably high. The mainstay of first line treatment is centered on diuretic therapy and fluid management. This chapter discusses the interactions between heart and kidney in HF, and focuses on the management of fluid overload. We discuss the mechanisms of diuretic resistance and its treatment. Recent trials performed on diuretic dosing and the comparisons of pharmacologic therapy to ultrafiltration are also reviewed.


Heart failure Diuretics Cardiorenal syndrome Loop diuretics Thiazide diuretics Potassium sparing diuretics Ultrafiltration Diuretic resistance Combination diuretic strategies 


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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Division of Nephrology, Department of Internal MedicineUniversity of Iowa Hospitals and ClinicsIowa CityUSA

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