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Outcomes with Combined Heart–Kidney Transplantation

  • Egolum Ugochukwu
  • Sandip Zalawadiya
Chapter

Abstract

Heart failure (HF) is leading cause of morbidity and mortality in the United States. Heart transplantation (HTx) remains the gold-standard treatment for those with advaced HF. Renal failure (RF) is an important prognosticator for mortality among HF patients, and is highly prevalent in this patient population. RF, both pre-HTx and post-HTx, is associated with adverse post-HTx outcomes; kidney transplantation (KT) after isolated HTx improves outcomes in these scenarios. Considering these observations, an increasing number of patients are undergoing combined heart–kidney transplantation (HKT) in recent years; in this chapter, we discuss outcomes related to combined HKT among adults in detail.

Abbreviations

CAV

Cardiac allograft vasculopathy

eGFR

Estimated glomerular filtration rate

HF

Heart failure

HKT

Heart–kidney transplantation

HTx

Heart transplantation

KDPI

Kidney donor profile index

KT

Kidney transplantation

MCSD

Mechanical circulatory support devices

RF

Renal failure

UNOS

United Network for Organ Sharing

Notes

Acknowledgment

Disclosures: None

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Division of Advanced Heart Failure and TransplantationVanderbilt University Medical CenterNashvilleUSA

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