Renal Replacement Therapies in Patients with Left Ventricular Assist Devices

  • Amanda K. Leonberg-YooEmail author
  • J. Eduardo Rame
  • Michael R. Rudnick


Increasing use of implantable left ventricular assist devices (LVADs) is occurring as a bridge to transplant or as a destination therapy in individuals with dual heart and kidney organ dysfunction. LVAD recipients who develop kidney failure are associated with increased adverse outcomes, particularly those who require maintenance dialysis. Challenges unique to this LVAD population with kidney failure include dialysis modality selection, management of dialysis access, and hemodynamic monitoring during maintenance dialysis, Dual heart–kidney transplant may also be considered in a subgroup, although survival outcomes are similar to heart transplant alone. It is necessary for the nephrologist to understand the basic management of an LVAD recipient in clinical practice, as it pertains to kidney dysfunction, dialysis needs, and transplant considerations.


Renal replacement therapy Left ventricular assist device Continuous renal replacement therapy Hemodialysis Peritoneal dialysis Combined heart and kidney transplant 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Amanda K. Leonberg-Yoo
    • 1
    Email author
  • J. Eduardo Rame
    • 2
  • Michael R. Rudnick
    • 3
  1. 1.Renal-Electrolyte and Hypertension Division, Department of MedicineUniversity of PennsylvaniaPhiladelphiaUSA
  2. 2.Division of Cardiology, Department of MedicineHeart Failure, Mechanical Assist and Cardiac Transplant Center, University of PennsylvaniaPhiladelphiaUSA
  3. 3.Penn Presbyterian Medical CenterPerleman School of Medicine of the University of PennsylvaniaPhiladelphiaUSA

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