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Suicide in Children and Adults with Epilepsy: A Complex Relationship

  • Jana E. Jones
  • Jessica M. Bordenave
Chapter

Abstract

Epilepsy is one of the most common neurological disorders, with approximately 50 million people worldwide diagnosed with epilepsy. Suicide is a potentially preventable cause of death in epilepsy, yet it accounts for a large proportion of mortality in epilepsy with rates reported to be three to five times higher compared to healthy controls in population-based studies. In this chapter, we reviewed a number of the complexities involved in suicide among people with epilepsy, including the following: (a) prevalence of suicide compared to the general population in adults and children, (b) risk factors for suicidal behavior, (c) the bidirectional relationship between epilepsy and suicide, (d) the role of antiepileptic drugs (AEDs) in suicide risk, and (e) assessment of suicidal behavior as well as a review of clinical interventions aimed at treatment and prevention of suicidal behavior and its risk factors in epilepsy.

Keywords

Epilepsy Suicide Prevalence Comorbidity Seizures Screening 

Abbreviations

AEDs

Antiepileptic drugs

aHR

Adjusted hazard ratio

aOR

Adjusted odds ratio

CDC

Centers for Disease Control and Prevention

CI

Confidence interval

FDA

US Food and Drug Administration

IRR

Incidence rate ratio

KSADS

Kiddie Schedule for Affective Disorders and Schizophrenia – Present and Lifetime Version

OR

Odds ratio

PR

Prevalence ratio

SMR

Standardized mortality ratio

TLE

Temporal lobe epilepsy

WCST

Wisconsin Card Sorting Test

WHO

World Health Organization

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of NeurologyUniversity of Wisconsin School of Medicine and Public HealthMadisonUSA

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