Where It All Began

  • Andreas Bikfalvi
Chapter

Abstract

Algire had observed changes in blood vessels when treating fibroblasts with a chemical methyl cholanthrene [98]. This suggests that factors (after stimulation) could be produced from the cells surrounding the blood vessels, such as fibroblasts that stimulate vascular growth.

References

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    Algire GH, Chalkley HW, Earle WE, Legallais FY, Park HD, Shelton E, Schilling EL (1950) Vascular reactions of normal and malignant tissues in vivo. III Vascular reactions’ of mice to fibroblasts treated in vitro with methylcholanthrene. J Natl Cancer Inst 11(3):555–580PubMedGoogle Scholar
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    Michaelson IC (1948) The mode of development of the vascular system of the retina, with some observations on its significance for certain retinal disease. Trans Ophthalmol Soc UK 68:137–180Google Scholar
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    Campbell FM (1951) The influence of a low atmospheric pressure on the development of the retinal vessels in the rat. Trans Ophthalmol Soc UK 71:287–300Google Scholar
  4. 101.
    Gimbrone MA Jr, Leapman SB, Cotran RS, Folkman J (1972) Tumor dormancy in vivo by prevention of neovascularization. J Exp Med 136(2):261–276CrossRefGoogle Scholar
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    Folkman J, Merler E, Abernathy C, Williams G (1971) Isolation of a tumor factor responsible for angiogenesis. J Exp Med 133(2):275–288CrossRefGoogle Scholar
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Copyright information

© Springer International Publishing AG, part of Springer Nature 2017

Authors and Affiliations

  • Andreas Bikfalvi
    • 1
  1. 1.Angiogenesis and Tumor Microenvironment LaboratoryUniversity of Bordeaux and National Institute of Health and Medical ResearchPessacFrance

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