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Vitamin D and Autoimmune Diseases

  • Shir Azrielant
  • Yehuda Shoenfeld
Chapter
Part of the Contemporary Endocrinology book series (COE)

Abstract

Vitamin D has a crucial role in preserving musculoskeletal health and modulating the immune system; the latter has been a subject of great interest in recent years. Vitamin D deficiency is common in the general population and even more so among patients with various autoimmune diseases. Vitamin D deficiency has been previously linked to various autoimmune diseases, including multiple sclerosis, type 1 diabetes, inflammatory bowel diseases, and rheumatoid arthritis. In this chapter, the association between vitamin D deficiency and various autoimmune diseases will be discussed, as well as the possible therapeutic implications derived from this relationship.

Keywords

Vitamin D Autoimmunity SLE Type 1 diabetes MS IBD RA Psoriasis 

Abbreviations

AIH

Autoimmune hepatitis

AITD

Autoimmune thyroid diseases

BMI

Body mass index

CD

Crohn’s disease

dcSSc

Diffuse cutaneous systemic sclerosis

IBD

Inflammatory bowel diseases

JoSLE

Juvenile-onset systemic lupus erythematosus

KO

Knockout

lcSSc

Limited cutaneous systemic sclerosis

MRI

Magnetic resonance imaging

MS

Multiple sclerosis

PBC

Primary biliary cholangitis

RA

Rheumatoid arthritis

RR

Relative risk

SLE

Systemic lupus erythematosus

SS

Systemic sclerosis

TGF

Transforming growth factor

Th

T helper cells

Treg

T regulatory cells

UC

Ulcerative colitis

UV

Ultraviolet

UVB

Ultraviolet B

VDR

Vitamin D receptor

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Sheba Medical Center, The Zabludowicz Center for Autoimmune DiseasesRamat-GanIsrael
  2. 2.Sackler Faculty of MedicineTel-Aviv UniversityTel-AvivIsrael
  3. 3.Incumbent of the Laura Schwarz-Kip Chair for Research of Autoimmune DiseasesTel-Aviv UniversityTel-AvivIsrael

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