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Treatment of Bone Metastases: Future Directions

  • Guido Scoccianti
  • Rodolfo Capanna
Chapter

Abstract

Four main future directions in the treatment of bone metastases can likely be envisaged: fewer tumors in general population, fewer bone metastases in patients affected by tumors, less invasive therapies, and in selected cases highly invasive surgery also in metastatic patients who have been often banished to palliative treatment so far. Development and improvements of current techniques and introduction of new technological achievements are expected to improve actual therapeutic regimens. Nanotechnologies and a combination of diagnosis and treatment in the same time (theranostics) are likely to deeply change our approach to bone metastatic disease and, we hope, its results. New and less invasive surgical procedures are going to progressively decrease the surgical burden on most of the metastatic patients who will still need surgery, but at the same time, a growing number of these patients will undergo highly invasive surgery, due to the application of the criteria of primary tumor surgery also to metastatic patients, thanks to the improved survival. The future of the treatment of bone metastases will surely be a varied and variegated future, ranging from the use of extremely small devices, like nanoprobes, to the use of megaprostheses, and maybe also combinations of them. The clinician will have to be ready to manage a continuously growing range of therapeutic options and to have the capability to choose the right one for the specific patient.

Keywords

Bone metastases Orthopedic oncology Mini-invasive surgery Nanomedicine Future treatments 

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Orthopaedic Oncology and Reconstructive SurgeryCareggi University HospitalFlorenceItaly
  2. 2.Department of Orthopaedics and Traumatology, Translational Research and Innovative TechniquesUniversity of PisaPisaItaly

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