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Evolution of Resuscitation: What Is Damage Control Resuscitation?

  • Kyle J. Kalkwarf
  • John B. Holcomb
Chapter

Abstract

The current treatment for massively bleeding patients is nearly identical to practices developed by physicians caring for thousands of injured combatants during World War I and II. After being forgotten for half a century, these techniques made a resurgence in the form of damage control resuscitation early in the twenty-first century, based on therapies employed during wars in Southwest Asia. The concepts include limiting crystalloid, whole blood, or balance blood component transfusions to achieve permissive hypotension, preventing hypothermia, and stopping bleeding as quickly as possible.

Keywords

Damage control resuscitation Trauma Coagulopathy Balanced resuscitation Whole blood 

References

  1. 1.
    Beecher HK. Early care of the seriously wounded man. JAMA. 1951;145(4):193–200.CrossRefGoogle Scholar
  2. 2.
    Jennings CE. The intra-venous injection of fluid for severe hæmorrhage. The Lancet. 1882;120(3081):436–7.CrossRefGoogle Scholar
  3. 3.
    Jennings CE. The intra-venous injection of fluid for severe haemorrhage. The Lancet. 1883;121(3102):228–9.CrossRefGoogle Scholar
  4. 4.
    Pye-Smith RJ. Sheffield public hospital and dispensary: five cases of intravenous injection of saline fluid for hæmorrhage and collapse. The Lancet. 1892;139(3582):913–5.CrossRefGoogle Scholar
  5. 5.
    Schmidt PJ. Transfusion in America in the eighteenth and nineteenth centuries. N Engl J Med. 1968;279(24):1319–20.PubMedCrossRefPubMedCentralGoogle Scholar
  6. 6.
    Fraser J, Cowell EM. Clinical study of blood pressure in wound conditions. JAMA. 1918;70Google Scholar
  7. 7.
    Spinella PC. Warm fresh whole blood transfusion for severe hemorrhage: US military and potential civilian applications. Crit Care Med. 2008;36(7):S340–5.PubMedCrossRefPubMedCentralGoogle Scholar
  8. 8.
    Hess JR, Thomas MJ. Blood use in war and disaster: lessons from the past century. Transfusion. 2003;43(11):1622–33.PubMedCrossRefPubMedCentralGoogle Scholar
  9. 9.
    Beecher HK. Preparation of battle casualties for surgery. Ann Surg. 1945;121(6):769–92.PubMedPubMedCentralCrossRefGoogle Scholar
  10. 10.
    Beecher HK. Resuscitation, and anesthesia for wounded men, the management of traumatic shock. Springfield. Charles C: Thomas; 1949.Google Scholar
  11. 11.
    Giangrande PL. The history of blood transfusion. Br J Haematol. 2000;100:758–67.CrossRefGoogle Scholar
  12. 12.
    Robertson OH. Transfusion with preserved red blood cells. Br Med J. 1918;1(2999):691.PubMedPubMedCentralCrossRefGoogle Scholar
  13. 13.
    Cannon, Walter B. Traumatic Shock. New York: D. Appl Ther 1923.Google Scholar
  14. 14.
    Fogelman MJ, Wilson BJA. different concept of volume replacement in traumatic hypovolemia observations on injured man and animal. Am J Surg. 1960;99(5):694–701.PubMedCrossRefPubMedCentralGoogle Scholar
  15. 15.
    Shires T, Williams J, Brown F. Acute change in extracellular fluids associated with major surgical procedures. Ann Surg. 1961;154:803–10.PubMedPubMedCentralCrossRefGoogle Scholar
  16. 16.
    Shires T, Jackson DE. Postoperative salt tolerance. Arch Surg. 1962;84:703–6. PMID: 13912108PubMedCrossRefPubMedCentralGoogle Scholar
  17. 17.
    Wolfman EF, Neill SA, Heaps DK, Zuidema GD. Donor blood and isotonic salt solution. Effect on survival after hemorrhagic shock and operation. Arch Surg. 1963;86:869–73.PubMedCrossRefPubMedCentralGoogle Scholar
  18. 18.
    Shires T, Coln D, Carrico J, Lightfoot S. Fluid therapy in hemorrhagic shock. Arch Surg. 1964;88:688–93.PubMedPubMedCentralCrossRefGoogle Scholar
  19. 19.
    McClelland RN, Shires GT, Baxter CR, Coln CD, Carrico J. Balanced salt solution in the treatment of hemorrhagic shock. JAMA. 1967;199:830–4.PubMedCrossRefPubMedCentralGoogle Scholar
  20. 20.
    Carrico CJ, Canizaro PC, Shires GT. Fluid resuscitation following injury: rationale for the use of balanced salt solutions. Crit Care Med. 1976;4(2):46–54.PubMedCrossRefPubMedCentralGoogle Scholar
  21. 21.
    Davidsohn I. Speculation on future use of blood or blood component therapy. JAMA. 1967;202(10):970–2.PubMedCrossRefPubMedCentralGoogle Scholar
  22. 22.
    Chaplin H Jr. Packed red blood cells. N Engl J Med. 1969;281(7):364–7.PubMedCrossRefPubMedCentralGoogle Scholar
  23. 23.
    Committee AMA. on Transfusion and Transplantation. Something old, something new. JAMA. 1970;212(1):147.Google Scholar
  24. 24.
    Westphal RG. Rational alternatives to the use of whole blood. Ann Intern Med. 1972;76(6):987–90.PubMedCrossRefPubMedCentralGoogle Scholar
  25. 25.
    Moore FD, Shires G. Moderation. Ann Surg. 1967;166:300–1.PubMedPubMedCentralCrossRefGoogle Scholar
  26. 26.
    Moore FD. Should blood be whole or in parts? N Engl J Med. 1969;280(6):327–8.PubMedCrossRefPubMedCentralGoogle Scholar
  27. 27.
    Kashuk JL, Moore EE, Millikan JS, Moore JB. Major Abdominal Vascular Trauma-A Unified Approach. Journal of Trauma and Acute Care Surgery. 1982 Aug 1;22(8):672–9. RJ Lowe in DiscussionKashuk JL, Moore EE, Millikan JS, Moore JB Major abdominal vascular trauma--a unified approach J Trauma 2008;65:261-270 RJ Lowe in DiscussionGoogle Scholar
  28. 28.
    Counts RB, Haisch C, Simon TL, Maxwell NG, Heimbach DM, Carrico CJ. Hemostasis in massively transfused trauma patients. Ann Surg. 1979;190(1):91–9.PubMedPubMedCentralCrossRefGoogle Scholar
  29. 29.
    Shackford SR, Virgilio RW, Peters RM. Whole blood versus packed-cell transfusions: a physiologic comparison. Ann Surg. 1981;193(3):337–40.PubMedPubMedCentralCrossRefGoogle Scholar
  30. 30.
    Lucas CE, Ledgerwood AM. Clinical significance of altered coagulation tests after massive transfusion for trauma. Am Surg. 1981;47(3):125–30.PubMedPubMedCentralGoogle Scholar
  31. 31.
    Reed RL 2nd, Ciavarella D, Heimbach DM, Baron L, Pavlin E, Counts RB, Carrico CJ. Prophylactic platelet administration during massive transfusion. A prospective, randomized, double-blind clinical study. Ann Surg. 1986;203:40–8.PubMedPubMedCentralCrossRefGoogle Scholar
  32. 32.
    Bland R, Shoemaker WC, Shabot MM. Physiologic monitoring goals for the critically ill patient. Surg Gynecol Obstet. 1978;147(6):833–41.PubMedPubMedCentralGoogle Scholar
  33. 33.
    Shoemaker WC, Appel PL, Kram HB, Waxman K, Lee TS. Prospective trial of supranormal values of survivors as therapeutic goals in high-risk surgical patients. Chest J. 1988;94(6):1176–86.CrossRefGoogle Scholar
  34. 34.
    Fleming A, Bishop M, Shoemaker W, Appel P, Sufficool W, Kuvhenguwha A, Kennedy F, Wo CJ. Prospective trial of supranormal values as goals of resuscitation in severe trauma. Arch Surg. 1992;127:1175–9. Discussion 1179-1181PubMedCrossRefPubMedCentralGoogle Scholar
  35. 35.
    Bishop MH, Wo CCJ, Appel PL, et al. Relationship between supranormal circulatory values, time delays, and outcome in severely traumatized patients. Crit Care Med. 1993;21:56–60.PubMedCrossRefPubMedCentralGoogle Scholar
  36. 36.
    Boyd O, Grounds RM, Bennett ED. A randomized clinical trial of the effect of deliberate perioperative increase of oxygen delivery on mortality in high-risk surgical patients. JAMA. 1993;270(22):2699–707.PubMedCrossRefPubMedCentralGoogle Scholar
  37. 37.
    Bishop MH, Shoemaker WC, Appel PL, Meade P, Ordog GJ, Wasserberger J, Wo CJ, Rimle DA, Kram HB, Umali R. Prospective, randomized trial of survivor values of cardiac index, oxygen delivery, and oxygen consumption as resuscitation endpoints in severe trauma. J Trauma. 1995;38(5):780–7.PubMedCrossRefPubMedCentralGoogle Scholar
  38. 38.
    Gattinoni L, Brazzi L, Pelosi P, Latini R, Tognoni G, Pesenti A, Fumagalli RA. trial of goal-oriented hemodynamic therapy in critically ill patients. N Engl J Med. 1995;333(16):1025–32.PubMedCrossRefPubMedCentralGoogle Scholar
  39. 39.
    Velmahos GC, Demetriades D, Shoemaker WC, Chan LS, Tatevossian R, Wo CC, Vassiliu P, Cornwell EE III, Murray JA, Roth B, Belzberg H. Endpoints of resuscitation of critically injured patients: normal or supranormal?: a prospective randomized trial. Ann Surg. 2000;232(3):409–18.PubMedPubMedCentralCrossRefGoogle Scholar
  40. 40.
    Lee L, Moore EE, Hansen KC, Silliman CC, Chandler JG, Banerjee A. It’s not your grandfather’s field plasma. Surgery. 2013;153(6):857–60.PubMedCrossRefPubMedCentralGoogle Scholar
  41. 41.
    Spinella PC, Pidcoke HF, Strandenes G, Hervig T, Fisher A, Jenkins D, Yazer M, Stubbs J, Murdock A, Sailliol A, Ness PM. Whole blood for hemostatic resuscitation of major bleeding. Transfusion. 2016;56(S2):S190–202.PubMedCrossRefPubMedCentralGoogle Scholar
  42. 42.
    Brandstrup B, Tønnesen H, Beier-Holgersen R, Hjortsø E, Ørding H, Lindorff-Larsen K, Rasmussen MS, Lanng C, Wallin L, Iversen LH, Gramkow CS. Effects of intravenous fluid restriction on postoperative complications: comparison of two perioperative fluid regimens: a randomized assessor-blinded multicenter trial. Ann Surg. 2003;238(5):641.PubMedPubMedCentralCrossRefGoogle Scholar
  43. 43.
    Balogh Z, McKinley BA, Cocanour CS, Kozar RA, Valdivia A, Sailors RM, Moore FA. Supranormal trauma resuscitation causes more cases of abdominal compartment syndrome. Arch Surg. 2003;138:637–42.PubMedPubMedCentralCrossRefGoogle Scholar
  44. 44.
    Simmons RL, Collins JA, Heisterkamp CA 3rd, Mills DE, Andren R, Phillips LL. Coagulation disorders in combat casualties, I: acute changes after wounding. Ann Surg 1969;169(4):455–482.Google Scholar
  45. 45.
    MacLeod JB, Lynn M, McKenney MG, Cohn SM, Murtha M. Early coagulopathy predicts mortality in trauma. J Trauma. 2003;55(1):39–44.PubMedPubMedCentralCrossRefGoogle Scholar
  46. 46.
    Brohi K, Singh J, Heron M, Coats T. Acute traumatic coagulopathy. J Trauma. 2003;54:1127–30.CrossRefPubMedGoogle Scholar
  47. 47.
    Niles SE, McLaughlin DF, Perkins JG, Wade CE, Li Y, Spinella PC, Holcomb JB. Increased mortality associated with the early coagulopathy of trauma in combat casualties. J Trauma Injury Infect Crit Care. 2008;64(6):1459–63. discussion 1463-5CrossRefGoogle Scholar
  48. 48.
    Gunter OL Jr, BK A, Isbell JM, Mowery NT, Young PP, Cotton BA. Optimizing outcomes in damage control resuscitation: identifying blood product ratios associated with improved survival. J Trauma Injury Infect Crit Care. 2008;65(3):527–34.CrossRefGoogle Scholar
  49. 49.
    Pidcoke HF, Aden JK, Mora AG, Borgman MA, Spinella PC, Dubick MA, Blackbourne LH, Cap AP. Ten-year analysis of transfusion in Operation Iraqi Freedom and Operation Enduring Freedom: increased plasma and platelet use correlates with improved survival. J Trauma Acute Care Surg. 2012;73(6):S445–52.PubMedPubMedCentralCrossRefGoogle Scholar
  50. 50.
    Mabry RL, Holcomb JB, Baker AM, Cloonan CC, Uhorchak JM, Perkins DE, Canfield AJ, Hagmann JH. United States army rangers in Somalia: an analysis of combat casualties on an urban battlefield. J Trauma Acute Care Surg. 2000;49(3):515–29.CrossRefGoogle Scholar
  51. 51.
    Borgman MA, Spinella PC, Perkins JG, Grathwohl KW, Repine T, Beekley AC, Sebesta J, Jenkins D, Wade CE, Holcomb JB. The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital. J Trauma. 2007;63(4):805–13.PubMedPubMedCentralCrossRefGoogle Scholar
  52. 52.
    Holcomb JB, Jenkins D, Rhee P, Johannigman J, Mahoney P, Mehta S, Cox ED, Gehrke MJ, Beilman GJ, Schreiber M, Flaherty SF. Damage control resuscitation: directly addressing the early coagulopathy of trauma. J Trauma Acute Care Surg. 2007;62(2):307–10.CrossRefGoogle Scholar
  53. 53.
    Maegele M, Lefering R, Yucel N, Tjardes T, Rixen D, Paffrath T, Simanski C, Neugebauer E, Bouillon B. AG Polytrauma of the German Trauma Society (DGU). Early coagulopathy in multiple injury: an analysis from the German Trauma Registry on 8724 patients. Injury. 2007;38:298.PubMedCrossRefPubMedCentralGoogle Scholar
  54. 54.
    Tieu BH, Holcomb JB, Schreiber MA. Coagulopathy: its pathophysiology and treatment in the injured patient. World J Surg. 2007;31:1055–64.PubMedPubMedCentralCrossRefGoogle Scholar
  55. 55.
    Cotton BA, Au BK, Nunez TC, Gunter OL, Robertson AM, Young PP. Predefined massive transfusion protocols are associated with a reduction in organ failure and postinjury complications. J Trauma. 2009;66:41–8. discussion 48-49PubMedCrossRefPubMedCentralGoogle Scholar
  56. 56.
    Shah SK, Uray KS, Stewart RH, Laine GA, Cox CS. Resuscitation-induced intestinal edema and related dysfunction: state of the science. J Surg Res. 2011;166(1):120–30.PubMedCrossRefPubMedCentralGoogle Scholar
  57. 57.
    Duchesne JC, Kimonis K, Marr AB, Rennie KV, Wahl G, Wells JE, Islam TM, Meade P, Stuke L, Barbeau JM, Hunt JP, Baker CC, NE MS Jr. Damage control resuscitation in combination with damage control laparotomy: a survival advantage. J Trauma. 2010;69:46–52.PubMedPubMedCentralCrossRefGoogle Scholar
  58. 58.
    Feinman M, Cotton BA, Haut ER. Optimal fluid resuscitation in trauma: type, timing, and total. Curr Opin Crit Care. 2014;20(4):366–72.PubMedCrossRefPubMedCentralGoogle Scholar
  59. 59.
    Cotton BA, Reddy N, Hatch QM, LeFebvre E, Wade CE, Kozar RA, Gill BS, Albarado R, McNutt MK, Holcomb JB. Damage control resuscitation is associated with a reduction in resuscitation volumes and improvement in survival in 390 damage control laparotomy patients. Ann Surg. 2011;254(4):598–605.PubMedPubMedCentralCrossRefGoogle Scholar
  60. 60.
    Myburgh JA, Mythen MG. Resuscitation fluids. N Engl J Med. 2013;369:1243–51.PubMedCrossRefPubMedCentralGoogle Scholar
  61. 61.
    Lobo DN, Bostock KA, Neal KR, Perkins AC, Rowlands BJ, Allison SP. Effect of salt and water balance on recovery of gastrointestinal function after elective colonic resection: a randomized control trial. Lancet. 2002;359:1812–8.PubMedCrossRefPubMedCentralGoogle Scholar
  62. 62.
    Balogh Z, McKinley BA, Cocanour CS, Kozar RA, Holcomb JB, Ware DN, Moore FA. Secondary abdominal compartment syndrome is an elusive early complication of traumatic shock resuscitation. Am J Surg. 2002;184(6):538–43. discussion 543-4PubMedPubMedCentralCrossRefGoogle Scholar
  63. 63.
    Cotton BA, Guy JS, Morris JA Jr, Abumrad NA. The cellular, metabolic, and systemic consequences of aggressive fluid resuscitation strategies. Shock. 2006;26:115–21.PubMedPubMedCentralCrossRefGoogle Scholar
  64. 64.
    Ley EJ, Clond MA, Srour MK, Barnajian M, Mirocha J, Margulies DR, Salim A. Emergency department crystalloid resuscitation of 1.5 L or more is associated with increased mortality in elderly and nonelderly trauma patients. J Trauma. 2011;70:398–400.PubMedCrossRefPubMedCentralGoogle Scholar
  65. 65.
    Hatch QM, Osterhout LM, Podbielski J, Kozar RA, Wade CE, Holcomb JB, Cotton BA. Impact of closure at the first take back: complication burden and potential overutilization of damage control laparotomy. J Trauma. 2011;71(6):1503–11.PubMedPubMedCentralGoogle Scholar
  66. 66.
    Schnüriger B, Inaba K, Wu T, Eberle BM, Belzberg H, Demetriades D. Crystalloids after primary colon resection and anastomosis at initial trauma laparotomy: excessive volumes are associated with anastomotic leakage. J Trauma Acute Care Surg. 2011;70(3):603–10.CrossRefGoogle Scholar
  67. 67.
    Spinella PC, Perkins JG, Grathwohl KW, Repine T, Beekley AC, Sebesta J, Jenkins D, Azarow K, Holcomb JB. 31st CSH Research Working Group. Fresh whole blood transfusions in coalition military, foreign national, and enemy combatant patients during Operation Iraqi Freedom at a US combat support hospital. World J Surg. 2008;32(1):2–6.PubMedCrossRefPubMedCentralGoogle Scholar
  68. 68.
    Cotton BA, Harvin JA, Kostousouv V, Minei KM, Radwan ZA, Schöchl H, Wade CE, Holcomb JB, Matijevic N. Hyperfibrinolysis at admission is an uncommon but highly lethal event associated with shock and prehospital fluid administration. J Trauma Acute Care Surg. 2012;73(2):365–70. discussion 370PubMedCrossRefPubMedCentralGoogle Scholar
  69. 69.
    Duchesne JC, Heaney J, Guidry C, McSwain N Jr, Meade P, Cohen M, Schreiber M, Inaba K, Skiada D, Demetriades D, Holcomb J. Diluting the benefits of hemostatic resuscitation: a multi-institutional analysis. J Trauma Acute Care Surg. 2013;75(1):76–82.PubMedCrossRefPubMedCentralGoogle Scholar
  70. 70.
    Shrestha B, Holcomb JB, Camp EA, Del Junco DJ, Cotton BA, Albarado R, Gill BS, Kozar RA, Kao LS, McNutt MK, Moore LJ, Love JD, Tyson GH 3rd, Adams PR, Khan S, Wade CE. Damage-control resuscitation increases successful nonoperative management rates and survival after severe blunt liver injury. J Trauma Acute Care Surg. 2015;78(2):336–41.PubMedCrossRefPubMedCentralGoogle Scholar
  71. 71.
    Spinella PC, Perkins JG, Grathwohl KW, Beekley AC, Niles SE, McLaughlin DF, Wade CE, Holcomb JB. Effect of plasma and red blood cell transfusions on survival in patients with combat related traumatic injuries. J Trauma. 2008;64(2 Suppl):S69–77. discussion S77–8PubMedPubMedCentralCrossRefGoogle Scholar
  72. 72.
    Holcomb JB, Wade CE, Michalek JE, Chisholm GB, Zarzabal LA, Schreiber MA, Gonzalez EA, Pomper GJ, Perkins JG, Spinella PC, Williams KL, Park MS. Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients. Ann Surg. 2008;248(3):447–58.PubMedPubMedCentralGoogle Scholar
  73. 73.
    Duchesne JC, Hunt JP, Wahl G, Marr AB, Wang YZ, Weintraub SE, Wright MJ, McSwain NE Jr. Review of current blood transfusions strategies in a mature level I trauma center: were we wrong for the last 60 years. J Trauma. 2008;65:272–6. Discussion 276-278PubMedCrossRefPubMedCentralGoogle Scholar
  74. 74.
    Maegele M, Lefering R, Paffrath T, Tjardes T, Simanski C, Bouillon B. Working Group on Polytrauma of the German Society of Trauma Surgery (DGU). Red-blood-cell to plasma ratios transfused during massive transfusion are associated with mortality in severe multiple injury: a retrospective analysis from the Trauma Registry of the Deutsche Gesellschaft für Unfallchirurgie. Vox Sang. 2008;95(2):112–9.PubMedCrossRefPubMedCentralGoogle Scholar
  75. 75.
    Sperry JL, Ochoa JB, Gunn SR, Alarcon LH, Minei JP, Cuschieri J, Rosengart MR, Maier RV, Billiar TR, Peitzman AB, Moore EE. Inflammation the host response to injury investigators. An FFP:PRBC transfusion ratio >/=1:1.5 is associated with a lower risk of mortality after massive transfusion. J Trauma. 2008;65:986.PubMedCrossRefPubMedCentralGoogle Scholar
  76. 76.
    Teixeira PG, Inaba K, Shulman I, Salim A, Demetriades D, Brown C, Browder T, Green D, Rhee P. Impact of plasma transfusion in massively transfused trauma patients. J Trauma Injury Infect Crit Care. 2009;66(3):693–7.CrossRefGoogle Scholar
  77. 77.
    Brown LM, Aro SO, Cohen MJ, Trauma Outcomes Group, Holcomb JB, Wade CE, Brasel KJ, Vercruysse G, MacLeod J, Dutton RP, Hess JR, Duchesne JC, NE MS, Muskat P, Johannigamn J, Cryer HM, Tillou A, Pittet JF, Knudson P, De Moya MA, Schreiber MA, Tieu B, Brundage S, Napolitano LM, Brunsvold M, Sihler KC, Beilman G, Peitzman AB, Zenait MS, Sperry J, Alarcon L, Croce MA, Minei JP, Kozar R, Gonzalez EA, Stewart RM, Cohn SM, Mickalek JE, Bulger EM, Cotton BA, Nunez TC, Ivatury R, Meredith JW, Miller P, Pomper GJ, Marin B. A high fresh frozen plasma: packed red blood cell transfusion ratio decreases mortality in all massively transfused trauma patients regardless of admission international normalized ratio. J Trauma. 2011;71(2 Suppl 3):S358–63.PubMedPubMedCentralCrossRefGoogle Scholar
  78. 78.
    Rowell SE, Barbosa RR, Diggs BS, Schreiber MA, Trauma Outcomes Group, Holcomb JB, Wade CE, Brasel KJ, Vercruysse G, MacLeod J, Dutton RP, Hess JR, Duchesne JC, NE MS, Muskat P, Johannigamn J, Cryer HM, Tillou A, Cohen MJ, Pittet JF, Knudson P, De Moya MA, Schreiber MA, Tieu B, Brundage S, Napolitano LM, Brunsvold M, Sihler KC, Beilman G, Peitzman AB, Zenait MS, Sperry J, Alarcon L, Croce MA, Minei JP, Kozar R, Gonzalez EA, Stewart RM, Cohn SM, Mickalek JE, Bulger EM, Cotton BA, Nunez TC, Ivatury R, Meredith JW, Miller P, Pomper GJ, Marin B. Effect of high product ratio massive transfusion on mortality in blunt and penetrating trauma patients. J Trauma. 2011;71(2 Suppl 3):S353–7.PubMedCrossRefPubMedCentralGoogle Scholar
  79. 79.
    Perkins JG, Cap AP, Spinella PC, Blackbourne LH, Grathwohl KW, Repine TB, Ketchum L, Waterman P, Lee RE, Beekley AC, Sebesta JA, Shorr AF, Wade CE, Holcomb JB. An evaluation of the impact of apheresis platelets used in the setting of massively transfused trauma patients. J Trauma. 2009;66:S77–85.PubMedCrossRefPubMedCentralGoogle Scholar
  80. 80.
    Zink KA, Sambasivan CN, Holcomb JB, Chisholm G, Schreiber MA. A high ratio of plasma and platelets to packed red blood cells in the first 6 hours of massive transfusion improves outcomes in a large multicenter study. Am J Surg. 2009;197(5):565–70. discussion 570PubMedCrossRefPubMedCentralGoogle Scholar
  81. 81.
    Inaba K, Branco BC, Rhee P, Blackbourne LH, Holcomb JB, Teixeira PG, Shulman I, Nelson J, Demetriades D. Impact of plasma transfusion in trauma patients who do not require massive transfusion. J Am Coll Surg. 2010;210(6):957–65.PubMedCrossRefPubMedCentralGoogle Scholar
  82. 82.
    Holcomb JB, Zarzabal LA, Michalek JE, Kozar RA, Spinella PC, Perkins JG, Matijevic N, Dong JF, Pati S, Wade CE, Trauma Outcomes Group, Holcomb JB, Wade CE, Cotton BA, Kozar RA, Brasel KJ, Vercruysse GA, JB ML, Dutton RP, Hess JR, Duchesne JC, NE MS, Muskat PC, Johannigamn JA, Cryer HM, Tillou A, Cohen MJ, Pittet JF, Knudson P, MA DM, Schreiber MA, Tieu BH, Brundage SI, Napolitano LM, Brunsvold ME, Sihler KC, Beilman GJ, Peitzman AB, Zenati MS, Sperry JL, Alarcon LH, Croce MA, Minei JP, Steward RM, Cohn SM, Michalek JE, Bulger EM, Nunez TC, Ivatury RR, Meredith JW, Miller PR, Pomper GJ, Marin B. Increased platelet:RBC ratios are associated with improved survival after massive transfusion. J Trauma. 2011;71(2 Suppl 3):S318–28.PubMedCrossRefPubMedCentralGoogle Scholar
  83. 83.
    Holcomb JB, del Junco DJ, Fox EE, Wade CE, Cohen MJ, Schreiber MA, Alarcon LH, Bai Y, Brasel KJ, Bulger EM, Cotton BA, Matijevic N, Muskat P, Myers JG, Phelan HA, White CE, Zhang J, Rahbar MH, PROMMTT Study Group. The prospective, observational, multicenter, major trauma transfusion (PROMMTT) study: comparative effectiveness of a time-varying treatment with competing risks. JAMA Surg. 201;148(2):127–36.Google Scholar
  84. 84.
    Malone DL, Hess JR, Fingerhut A. Massive transfusion practices around the globe and a suggestion for a common massive transfusion protocol. J Trauma. 2006;60(6 Suppl):S91–6.PubMedCrossRefPubMedCentralGoogle Scholar
  85. 85.
    Hess JR, Holcomb JB. Resuscitating properly. Transfusion. 2015;55(6):1362–4.PubMedCrossRefPubMedCentralGoogle Scholar
  86. 86.
    Treml AB, Gorlin JB, Dutton RP, Scavone BM. Massive transfusion protocols: a survey of academic medical centers in the United States. Anesth Anal. 2017;124(1):277–81.CrossRefGoogle Scholar
  87. 87.
    Snyder CW, Weinberg JA, Jr MGG, Melton SM, George RL, Reiff DA, Cross JM, Hubbard-Brown J, Rue LW 3rd, Kerby JD. The relationship of blood product ratio to mortality: survival benefit or survival bias. J Trauma Injury Infect. Crit Care. 2009;66(2):358–62.Google Scholar
  88. 88.
    Zielinski MD, Johnson PM, Jenkins D, Goussous N, Stubbs JR. Emergency use of prethawed Group A plasma in trauma patients. J Trauma Acute Care Surg. 2013;74(1):69–75.PubMedCrossRefPubMedCentralGoogle Scholar
  89. 89.
    Matijevic N, Wang YW, Cotton BA, Hartwell E, Barbeau JM, Wade CE, Holcomb JB. Better hemostatic profiles of never-frozen liquid plasma compared with thawed fresh frozen plasma. J Trauma Acute Care Surg. 2013;74(1):84–90. discussion 90-1PubMedCrossRefPubMedCentralGoogle Scholar
  90. 90.
    Radwan ZA, Bai Y, Matijevic N, del Junco DJ, McCarthy JJ, Wade CE, Holcomb JB, Cotton BA. An emergency department thawed plasma protocol for severely injured patients. JAMA Surg. 2013;148(2):170–5.PubMedPubMedCentralCrossRefGoogle Scholar
  91. 91.
    Holcomb JB, Pati S. Optimal trauma resuscitation with plasma as the primary resuscitative fluid: the surgeon's perspective. Hematology Am Soc Hematol Educ Program. 2013;2013:656–9.PubMedPubMedCentralGoogle Scholar
  92. 92.
    Norii T, Crandall C, Terasaka Y. Survival of severe blunt trauma patients treated with resuscitative endovascular balloon occlusion of the aorta compared with propensity score-adjusted untreated patients. J Trauma Acute Care Surg. 2015;78(4):721–8.PubMedCrossRefPubMedCentralGoogle Scholar
  93. 93.
    Ho AM, Zamora JE, Holcomb JB, Ng CS, Karmakar MK, Dion PW. The many faces of survivor bias in observational studies on trauma resuscitation requiring massive transfusion. Ann Emerg Med. 2015;66(1):45–8.PubMedCrossRefPubMedCentralGoogle Scholar
  94. 94.
    Holcomb JB, Tilley BC, Baraniuk S, Fox EE, Wade CE, Podbielski JM, del Junco DJ, Brasel KJ, Bulger EM, Callcut RA, Cohen MJ, Cotton BA, Fabian TC, Inaba K, Kerby JD, Muskat P, O’Keeffe T, Rizoli S, Robinson BR, Scalea TM, Schreiber MA, Stein DM, Weinberg JA, Callum JL, Hess JR, Matijevic N, Miller CN, Pittet JF, Hoyt DB, Pearson GD, Leroux B, van Belle G, PROPPR Study Group. Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial. JAMA. 2015;313(5):471–82.PubMedPubMedCentralCrossRefGoogle Scholar
  95. 95.
    Demetriades D, Kimbrell B, Salim A, Velmahos G, Rhee P, Preston C, Gruzinski G, Chan L. Trauma deaths in a mature urban trauma system: is “trimodal” distribution a valid concept? J Am Coll Surg. 2005;201(3):343–8.PubMedCrossRefPubMedCentralGoogle Scholar
  96. 96.
    Oyeniyi BT, Fox EE, Scerbo M, Tomasek JS, Wade CE, Holcomb JB. Trends in 1029 trauma deaths at a level 1 trauma center: Impact of a bleeding control bundle of care. Injury. 2016;3Google Scholar
  97. 97.
    Fox EE, Holcomb JB, Wade CE, Bulger EM, Tilley BC. On behalf of the PROPPR study group. Earlier endpoints are required for hemorrhagic shock trials among severely injured patients. Shock. [Submitted for publication].Google Scholar
  98. 98.
    Kauvar DS, Holcomb JB, Norris GC, Hess JR. Fresh whole blood transfusion: a controversial military practice. J Trauma. 2006;61(1):181–4.PubMedCrossRefPubMedCentralGoogle Scholar
  99. 99.
    Murdock AD, BersÈus O, Hervig T, Strandenes G, Lunde TH. Whole blood: the future of traumatic hemorrhagic shock resuscitation. Shock. 2014;41:62–9.PubMedCrossRefPubMedCentralGoogle Scholar
  100. 100.
    Spinella PC, Perkins JG, Grathwohl KW, Beekley AC, Holcomb JB. Warm fresh whole blood is independently associated with improved survival for patients with combat-related traumatic injuries. J Trauma Injury Infect Crit Care. 2009;66(4 Suppl):S69–76.CrossRefGoogle Scholar
  101. 101.
    Holcomb JB, Spinella PC. Optimal use of blood in trauma patients. Biologicals. 2010;38(1):72–7.PubMedPubMedCentralCrossRefGoogle Scholar
  102. 102.
    Repine TB, Perkins JG, Kauvar DS, Blackborne L. The use of fresh whole blood in massive transfusion. J Trauma Injury Infect Crit Care. 2006;60(6 suppl):S59–69.CrossRefGoogle Scholar
  103. 103.
    Kowalenko T, Stern S, Dronen S, Wang X. Improved outcome with hypotensive resuscitation of uncontrolled hemorrhagic shock in a swine model. J Trauma Acute Care Surg. 1992;33(3):349–53.CrossRefGoogle Scholar
  104. 104.
    Burris D, Rhee P, Kaufmann C, Pikoulis E, Austin B, Eror A, DeBraux S, Guzzi L, Leppäniemi A. Controlled resuscitation for uncontrolled hemorrhagic shock. J Trauma. 1999;46:216–23.PubMedCrossRefPubMedCentralGoogle Scholar
  105. 105.
    Holmes JF, Sakles JC, Lewis G, Wisner DH. Effects of delaying fluid resuscitation on an injury to the systemic arterial vasculature. Acad Emerg Med. 2002;9:267–74.PubMedCrossRefPubMedCentralGoogle Scholar
  106. 106.
    Holcomb JB. Fluid resuscitation in modern combat casualty care: lessons learned from Somalia. J Trauma. 2003;54(5 Suppl):S46–51. ReviewPubMedPubMedCentralGoogle Scholar
  107. 107.
    Sondeen JL, Coppes VG, Holcomb JB. Blood pressure at which rebleeding occurs after resuscitation in swine with aortic injury. J Trauma Injury Infect. Crit Care. 2003;54(5 suppl):S110–7.Google Scholar
  108. 108.
    Bickell WH, Wall MJ Jr, Pepe PE, Martin RR, Ginger VF, Allen MK, Mattox KL. Immediate versus delayed fluid resuscitation for hypotensive patients with penetrating torso injuries. N Engl J Med. 1994;331(17):1105–9.PubMedPubMedCentralCrossRefGoogle Scholar
  109. 109.
    Wall MJ Jr, Granchi TS, Liscum K, Aucar J, Mattox KL. Delayed versus immediate fluid resuscitation in patients with penetrating trauma: subgroup analysis. J Trauma. 1995;39:173.Google Scholar
  110. 110.
    Schreiber MA, Meier EN, Tisherman SA, Kerby JD, Newgard CD, Brasel K, Egan D, Witham W, Williams C, Daya M, Beeson J. A controlled resuscitation strategy is feasible and safe in hypotensive trauma patients: results of a prospective randomized pilot trial. J Trauma Acute Care Surg. 2015;78(4):687.PubMedPubMedCentralCrossRefGoogle Scholar
  111. 111.
    Jurkovich GJ, Greiser WB, Luterman A, Curreri PW. Hypothermia in trauma victims: an ominous predictor of survival. J Trauma. 1987;27(9):1019–24.PubMedPubMedCentralCrossRefGoogle Scholar
  112. 112.
    Ferrara A, MacArthur JD, Wright HK, Modlin IM, McMillen MA. Hypothermia and acidosis worsen coagulopathy in the patient requiring massive transfusion. Am J Surg. 1990;160:515–8.PubMedCrossRefPubMedCentralGoogle Scholar
  113. 113.
    Cosgriff NM, Ernest E, Sauaia A, Kenny-Moynihan M, Burch JM, Galloway B. Predicting life-threatening coagulopathy in the massively transfused patient: hypothermia and acidosis revisited. J Trauma Injury Infect Crit Care. 1997;42(5):857–62.CrossRefGoogle Scholar
  114. 114.
    Martini WZ, Holcomb JB. Acidosis and coagulopathy: the differential effects on fibrinogen synthesis and breakdown in pigs. Ann Surg. 2007;246(5):831–5.PubMedCrossRefPubMedCentralGoogle Scholar
  115. 115.
    Hess JR, Brohi K, Dutton RP, Hauser CJ, Holcomb JB, Kluger Y, Mackway-Jones K, Parr MJ, Rizoli SB, Yukioka T, Hoyt DB, Bouillon B. The coagulopathy of trauma: a review of mechanisms. J Trauma. 2008 Oct;65(4):748–54.CrossRefPubMedGoogle Scholar
  116. 116.
    Eastridge BJ, Mabry RL, Seguin P, Cantrell J, Tops T, Uribe P, Mallett O, Zubko T, Oetjen-Gerdes L, Rasmussen TE, Butler FK. Death on the battlefield (2001–2011): implications for the future of combat casualty care. J Trauma Acute Care Surg. 2012;73(6):S431–7.CrossRefPubMedGoogle Scholar
  117. 117.
    Kragh JF Jr, Walters TJ, Baer DG, Fox CJ, Wade CE, Salinas J, Holcomb JB. Practical use of emergency tourniquets to stop bleeding in major limb trauma. J Trauma Acute Care Surg. 2008;64(2):S38–50.CrossRefGoogle Scholar
  118. 118.
    Scerbo MH, Mumm JP, Gates K, Love JD, Wade CE, Holcomb JB, Cotton BA. Safety and appropriateness of tourniquets in 105 civilians. Prehosp Emerg Care. 2016;May 31:1–11. [Epub ahead of print]Google Scholar
  119. 119.
    Shina A, Lipsky AM, Nadler R, Levi M, Benov A, Ran Y, Yitzhak A, Glassberg E. Prehospital use of hemostatic dressings by the Israel Defense Forces Medical Corps: A case series of 122 patients. J Trauma Acute Care Surg. 2015;79(4):S204–9.PubMedCrossRefPubMedCentralGoogle Scholar
  120. 120.
    Inaba K, Siboni S, Resnick S, Zhu J, Wong MD, Haltmeier T, Benjamin E, Demetriades D. Tourniquet use for civilian extremity trauma. J Trauma Acute Care Surg. 2015;79(2):232–7. quiz 332-3PubMedPubMedCentralCrossRefGoogle Scholar
  121. 121.
    Moore LJ, Brenner M, Kozar RA, Pasley J, Wade CE, Baraniuk MS, Scalea T, Holcomb JB. Implementation of resuscitative endovascular balloon occlusion of the aorta as an alternative to resuscitative thoracotomy for noncompressible truncal hemorrhage. J Trauma Acute Care Surg. 2015;79(4):523–30. discussion 530-2PubMedCrossRefPubMedCentralGoogle Scholar
  122. 122.
    Morrison JJ, Galgon RE, Jansen JO, Cannon JW, Rasmussen TE, Eliason JLA. systematic review of the use of resuscitative endovascular balloon occlusion of the aorta in the management of hemorrhagic shock. J Trauma Acute Care Surg. 2016;80(2):324–34.CrossRefPubMedGoogle Scholar
  123. 123.
    Spinella PC, Holcomb JB. Resuscitation and transfusion principles for traumatic hemorrhagic shock. Blood Rev. 2009;23(6):231–40.PubMedPubMedCentralCrossRefGoogle Scholar
  124. 124.
    Otton BA, Minei KM, Radwan ZA, Matijevic N, Pivalizza E, Podbielski J, Wade CE, Kozar RA, Holcomb JB. Admission rapid thrombelastography predicts development of pulmonary embolism in trauma patients. J Trauma Acute Care Surg. 2012;72(6):1470–5.CrossRefGoogle Scholar
  125. 125.
    Holcomb JB, Minei KM, Scerbo ML, Radwan ZA, Wade CE, Kozar RA, Gill BS, Albarado R, McNutt MK, Khan S, Adams PR, McCarthy JJ, Cotton BA. Admission rapid thrombelastography can replace conventional coagulation tests in the emergency department: experience with 1974 consecutive trauma patients. Ann Surg. 2012;256(3):476–86.PubMedCrossRefPubMedCentralGoogle Scholar
  126. 126.
    Johansson PI, Stensballe J, Oliveri R, Wade CE, Ostrowski SR, Holcomb JB. How I treat patients with massive hemorrhage. Blood. 2014;124(20):3052–8.PubMedCrossRefPubMedCentralGoogle Scholar
  127. 127.
    Cotton BA, Faz G, Hatch QM, Radwan ZA, Podbielski J, Wade C, Kozar RA, Holcomb JB. Rapid thrombelastography delivers real-time results that predict transfusion within 1 hour of admission. J Trauma. 2011;71(2):407–14. discussion 414-7PubMedPubMedCentralCrossRefGoogle Scholar
  128. 128.
    Gonzalez E, Moore EE, Moore HB, Chapman MP, Chin TL, Ghasabyan A, Wohlauer MV, Barnett CC, Bensard DD, Biffl WL, Burlew CC, Johnson JL, Pieracci FM, Jurkovich GJ, Banerjee A, Silliman CC, Sauaia A. Goal-directed hemostatic resuscitation of trauma-induced coagulopathy: a pragmatic randomized clinical trial comparing a viscoelastic assay to conventional coagulation assays. Ann Surg. 2016;263(6):1051–9.PubMedPubMedCentralCrossRefGoogle Scholar
  129. 129.
    Moore EE, Moore HB, Gonzalez E, Sauaia A, Banerjee A, Silliman CC. Rationale for the selective administration of tranexamic acid to inhibit fibrinolysis in the severely injured patient. Transfusion. 2016;56(Suppl 2):S110–4.PubMedPubMedCentralCrossRefGoogle Scholar
  130. 130.
    CRASH-2 Trial Collaborators, Shakur H, Roberts I, Bautista R, Caballero J, Coats T, Dewan Y, El-Sayed H, Gogichaishvili T, Gupta S, Herrera J, Hunt B, Iribhogbe P, Izurieta M, Khamis H, Komolafe E, Marrero MA, Mejía-Mantilla J, Miranda J, Morales C, Olaomi O, Olldashi F, Perel P, Peto R, Ramana PV, Ravi RR, Yutthakasemsunt S. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet. 2010;376(9734):23–32.CrossRefGoogle Scholar
  131. 131.
    CRASH-2 Collaborators, Roberts I, Shakur H, Afolabi A, Brohi K, Coats T, Dewan Y, Gando S, Guyatt G, Hunt BJ, Morales C, Perel P, Prieto-Merino D, Woolley T. The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial. Lancet. 2011;377:1096–101.CrossRefGoogle Scholar
  132. 132.
    Harvin JA, Peirce CA, Mims MM, Hudson JA, Podbielski JM, Wade CE, Holcomb JB, Cotton BA. The impact of tranexamic acid on mortality in injured patients with hyperfibrinolysis. J Trauma Acute Care Surg. 2015;78(5):905–11.PubMedCrossRefPubMedCentralGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of SurgeryMcGovern Medical School, University of Texas Health Sciences CenterHoustonUSA

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