Lichen Planopilaris

  • Pooya Khan Mohammad Beigi


Lichen planopilaris (LPP) is a relatively uncommon form of inflammatory hair loss [1]. It involves autoimmune destruction of the hair follicles by lymphocytes and results in progressive scarring alopecia of the scalp. LPP can present alone or be superimposed with cutaneous, nail, or mucous membrane types of lichen planus. There are three types of LPP:
  1. 1.

    Classic LPP

  2. 2.

    Frontal fibrosing LPP

  3. 3.

    Graham Little syndrome



Lichen planopilaris (LPP) Graham Little syndrome Frontal fibrosing alopecia Follicle hyperkeratosis Perifollicular erythema Glabrous skin Inflammation T lymphocyte HPV H. pylori Syphilis Antimalarial medication Beta blockers ACE inhibitors Thiazides Follicular epithelium Keratinocytes Biopsy Lichen planus lesions Lichenoid lymphocytic infiltrate Infundibulum, Isthmus Sebaceous glands Dermatitis Perifollicular lamellar fibrosis Papillary dermis Dermoepidermal junction Infundibulum Anti-IgM Anti-IgA Anti-IgC Triamcinolone acetonide Corticosteroids Clobetasol Oral corticosteroid Prednisone Hydroxychloroquine Cyclosporine Mycophenolate mofetil 


  1. 1.
    Kang H, Alzolibani AA, Otberg N, Shapiro J. Lichen planopilaris. Dermatol Ther. 2008;21(4):249–56. Scholar
  2. 2.
    Rawat R, Mahajan VK, Chander B, Mehta KS, Chauhan PS, Gupta M. Graham little picardi lassueur syndrome. Our Dermatol Online. 2016;7(1):114–6. Scholar
  3. 3.
    Tan E, Martinka M, Ball N, Shapiro J. Primary cicatricial alopecias: clinicopathology of 112 cases. J Am Acad Dermatol. 2004;50:25–32.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Pooya Khan Mohammad Beigi
    • 1
    • 2
    • 3
  1. 1.Department of Health ManagementNew York Medical CollegeValhallaUSA
  2. 2.University of British ColumbiaVancouverCanada
  3. 3.Misdiagnosis AssociationSeattleUSA

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