Ethics in Clinical Cancer Research

  • Rodrigo Santa C. Guindalini
  • Rachel P. Riechelmann
  • Roberto Jun Arai
Chapter

Abstract

Evidence-based medicine (EBM) has proven to be fundamental in the modern era. The clinical data derived from rigorous research protocols to support EBM has moved towards a high level of complexity to achieve the best level of evidence. However, the pursuit to retrieve organized data intersects with routine medical care. To accommodate significant advances in the area of precision medicine and to streamline the drug development process, newer and even more complex clinical trial design approaches have emerged. In this context, medical innovation not only creates new ethical concerns, but also prompts new considerations in long-standing ethics discussions. In this chapter, we will explore some of the major ethical concerns that arise in the course of modern clinical cancer research, as well as proposing recommendations to protect the rights, safety, and welfare of study subjects.

Keywords

Clinical cancer research Early-phase trial Ethics Informed consent Oncology Precision medicine Therapeutic expectation 

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Rodrigo Santa C. Guindalini
    • 1
    • 2
  • Rachel P. Riechelmann
    • 3
  • Roberto Jun Arai
    • 4
  1. 1.CLION, CAM GroupSalvadorBrazil
  2. 2.Department of Radiology and OncologyState of São Paulo Cancer Institute, Faculty of Medicine, University of São PauloSão PauloBrazil
  3. 3.Department of Clinical OncologyAC Camargo Cancer CenterSão PauloBrazil
  4. 4.Clinical Research UnitState of São Paulo Cancer Institute, Faculty of Medicine, University of São PauloSão PauloBrazil

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