Review of von Willebrand Disease and Perioperative Management in Dentistry

  • Richard P. SzumitaEmail author


von Willebrand disease (vWD) is the most common inherited coagulation disorder. In addition, vWD can also be acquired later in life in patients with no previous history of pathologic bleeding. vWD is the result of either a quantitative deficit or a qualitative defect in von Willebrand factor (vWF). Each patient’s disease is classified based on the type of defect in vWF. Dental and surgical management of patients with vWD is based on the severity of their disease, and several systemic and local treatments are available to allow for the hemorrhage control. This chapter will review important aspects of vWF, classification of vWD, and treatment of the dental patient with vWD.


von Willebrand disease (vWD) von Willebrand factor (vWF) Endothelial cells Subendothelium Platelet membrane receptor Glycoprotein Ib/IX/V Mucocutaneous bleeding Desmopressin Aminocaproic acid Tranexamic acid 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Dentistry/Oral and Maxillofacial SurgerySt. Joseph’s University Medical CenterPatersonUSA
  2. 2.Private PracticeLittle FallsUSA

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