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Heart-on-a-chip Systems

  • Magdalena Bulka
  • Elzbieta JastrzebskaEmail author
Chapter

Abstract

Heart diseases are the most common cause of death around the world. Therefore, it is important to develop new drugs and therapies, which can be useful in the treatment of cardiovascular diseases (CVDs). Elaboration of in vivo-like culture models of heart cells will allow the mimicking of native heart tissue and the investigation of heart cell response to the exposure of external stimuli. Heart-on-a-chip systems can be successfully used to imitate heart tissue functions and to perform assays based on cardiotherapy. In this chapter, we present Heart-on-a-chip systems, which can be utilized for various types of assays. Different cardiac cell cultures performed in Lab-on-a-chip systems are characterized at the beginning of this chapter. Single, monolayer, and spatial cell cultures are presented. Next, examples of cardiotoxicity assays and electrical stimulations performed in Heart-on-a-chip systems are described. Methods of heart cell analysis used in microscale are also defined. Finally, we summarize the research focused on Heart-on-a-chip systems and we outline perspectives for the usage of such microsystems.

Keywords

Cardiomyocytes Cardiovascular disease Heart-on-a-chip Stem cells Vascular system 

Notes

Acknowledgements

This work was realized with the frame of project LIDER No. LIDER/026/573/L-4/12/NCBR/2013.

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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.The Chair of Medical Biotechnology, Faculty of ChemistryWarsaw University of TechnologyWarsawPoland

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