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Psychoneuroendocrinology of Resilience: An Overview

  • Avinash De Sousa
  • Amresh Shrivastava
  • Charles B. Nemeroff
Chapter

Abstract

Resilience is defined as the ability to bounce back from trauma and stressful situations. Resilience has many psychosocial and biological variables that play a role in its genesis and development. The present chapter looks at the psychoneuroendocrinological basis of resilience and looks at various hormones that play a role in the genesis, development and maintenance of resilience.

Keywords

Psychoneuroendorinology Resilience 

Notes

Acknowledgements

Nil.

Financial Disclosures

Nil.

Source of Support

Nil.

Conflict of Interest

Nil.

References

  1. 1.
    Rutten BP, Hammels C, Geschwind N, Menne-Lothmann C, Pishva E, Schruers K, Den Hove D, Kenis G, Os J, Wichers M. Resilience in mental health: linking psychological and neurobiological perspectives. Acta Psychiatr Scand. 2013;128(1):3–20.CrossRefPubMedPubMedCentralGoogle Scholar
  2. 2.
    Schultze-Lutter F, Schimmelmann BG, Schmidt SJ. Resilience, risk, mental health and well-being: associations and conceptual differences. Eur Child Adolesc Psychiatry. 2016;25(5):459–66.CrossRefPubMedGoogle Scholar
  3. 3.
    Shastri PC. Resilience: building immunity in psychiatry. Indian J Psychiatry. 2013;55(3):224–34.CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    Shrivastava A, Desousa A. Resilience: a psychobiological construct for psychiatric disorders. Indian J Psychiatry. 2016;58(1):38–43.CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Karatsoreos IN, McEwen BS. Annual research review: the neurobiology and physiology of resilience and adaptation across the life course. J Child Psychol Psychiatry. 2013;54(4):337–47.CrossRefPubMedGoogle Scholar
  6. 6.
    Cummins RA, Wooden M. Personal resilience in times of crisis: the implications of SWB homeostasis and set-points. J Happiness Stud. 2014;15(1):223–35.CrossRefGoogle Scholar
  7. 7.
    McEwen BS, Gray JD, Nasca C. Recognizing resilience: learning from the effects of stress on the brain. Neurobiol Stress. 2015;31:1–11.CrossRefGoogle Scholar
  8. 8.
    Chida Y, Steptoe A. Cortisol awakening response and psychosocial factors: a systematic review and meta-analysis. Biol Psychol. 2009;80(3):265–78.CrossRefPubMedGoogle Scholar
  9. 9.
    Kudielka BM, Kirschbaum C. Sex differences in HPA axis responses to stress: a review. Biol Psychol. 2005;69(1):113–32.CrossRefGoogle Scholar
  10. 10.
    Fries E, Dettenborn L, Kirschbaum C. The cortisol awakening response (CAR): facts and future directions. Int J Psychophysiol. 2009;72(1):67–73.CrossRefPubMedGoogle Scholar
  11. 11.
    Starkman MN, Giordani B, Gebarski SS, Berent S, Schork MA, Schteingart DE. Decrease in cortisol reverses human hippocampal atrophy following treatment of Cushing’s disease. Biol Psychiatry. 1999;46(12):1595–602.CrossRefPubMedGoogle Scholar
  12. 12.
    Meewisse ML, Reitsma JB, De Vries GJ, Gersons BP, Olff M. Cortisol and post-traumatic stress disorder in adults. Br J Psychiatry. 2007;191(5):387–92.CrossRefPubMedGoogle Scholar
  13. 13.
    Carpenter LL, Carvalho JP, Tyrka AR, Wier LM, Mello AF, Mello MF, Anderson GM, Wilkinson CW, Price LH. Decreased adrenocorticotropic hormone and cortisol responses to stress in healthy adults reporting significant childhood maltreatment. Biol Psychiatry. 2007;62(10):1080–7.CrossRefPubMedPubMedCentralGoogle Scholar
  14. 14.
    Miller G, Chen E, Cole SW. Health psychology: developing biologically plausible models linking the social world and physical health. Annu Rev Psychol. 2009;60:501–24.CrossRefPubMedGoogle Scholar
  15. 15.
    Hoge EA, Austin ED, Pollack MH. Resilience: research evidence and conceptual considerations for posttraumatic stress disorder. Depress Anxiety. 2007;24(2):139–52.CrossRefPubMedGoogle Scholar
  16. 16.
    Jeckel M, Lopes RP, Berleze MC, Luz C, Feix L, Argimon II, Stein LM, Bauer ME. Neuroendocrine and immunological correlates of chronic stress in ‘strictly healthy populations. Neuroimmunomodulation. 2009;17(1):9–18.CrossRefPubMedGoogle Scholar
  17. 17.
    Wu G, Feder A, Cohen H, Kim JJ, Calderon S, Charney DS, Mathé AA. Understanding resilience. Front Behav Neurosci. 2013;7:10.PubMedPubMedCentralGoogle Scholar
  18. 18.
    Feder A, Nestler EJ, Charney DS. Psychobiology and molecular genetics of resilience. Nat Rev Neurosci. 2009;10(6):446–57.CrossRefPubMedPubMedCentralGoogle Scholar
  19. 19.
    Holsboer F, Ising M. Central CRH system in depression and anxiety—evidence from clinical studies with CRH 1 receptor antagonists. Eur J Pharmacol. 2008;583(2):350–7.CrossRefPubMedGoogle Scholar
  20. 20.
    Ivy AS, Rex CS, Chen Y, Dubé C, Maras PM, Grigoriadis DE, Gall CM, Lynch G, Baram TZ. Hippocampal dysfunction and cognitive impairments provoked by chronic early-life stress involve excessive activation of CRH receptors. J Neurosci. 2010;30(39):13005–15.CrossRefPubMedPubMedCentralGoogle Scholar
  21. 21.
    Zorrilla EP, Koob GF. Progress in corticotropin-releasing factor-1 antagonist development. Drug Discov Today. 2010;15(9):371–83.CrossRefPubMedPubMedCentralGoogle Scholar
  22. 22.
    Mohammad F, Ho J, Woo JH, Lim CL, Poon DJ, Lamba B, Claridge-Chang A. Concordance and incongruence in preclinical anxiety models: systematic review and meta-analyses. Neurosci Biobehav Rev. 2016;68:504–29.CrossRefPubMedGoogle Scholar
  23. 23.
    Maras PM, Baram TZ. Sculpting the hippocampus from within: stress, spines, and CRH. Trends Neurosci. 2012;35(5):315–24.CrossRefPubMedPubMedCentralGoogle Scholar
  24. 24.
    Chrousos GP. Stress and disorders of the stress system. Nat Rev Endocrinol. 2009;5(7):374–81.CrossRefGoogle Scholar
  25. 25.
    Morales-Medina JC, Dumont Y, Quirion R. A possible role of neuropeptide Y in depression and stress. Brain Res. 2010;1314:194–205.CrossRefPubMedGoogle Scholar
  26. 26.
    Gutman AR, Yang Y, Ressler KJ, Davis M. The role of neuropeptide Y in the expression and extinction of fear-potentiated startle. J Neurosci. 2008;28(48):12682–90.CrossRefPubMedPubMedCentralGoogle Scholar
  27. 27.
    Thorsell A. Brain neuropeptide Y and corticotropin-releasing hormone in mediating stress and anxiety. Exp Biol Med. 2010;235(10):1163–7.CrossRefGoogle Scholar
  28. 28.
    Li Q, Bartley AF, Dobrunz LE. Endogenously released neuropeptide Y suppresses hippocampal short-term facilitation and is impaired by stress-induced anxiety. J Neurosci. 2017;37(1):23–37.CrossRefPubMedPubMedCentralGoogle Scholar
  29. 29.
    Wu G, Feder A, Wegener G, Bailey C, Saxena S, Charney D, Mathé AA. Central functions of neuropeptide Y in mood and anxiety disorders. Expert Opin Ther Targets. 2011;15(11):1317–31.CrossRefPubMedGoogle Scholar
  30. 30.
    Sah R, Geracioti TD. Neuropeptide Y and posttraumatic stress disorder. Mol Psychiatry. 2013;18(6):646–55.CrossRefPubMedGoogle Scholar
  31. 31.
    Lang R, Gundlach AL, Kofler B. The galanin peptide family: receptor pharmacology, pleiotropic biological actions, and implications in health and disease. Pharmacol Ther. 2007;115(2):177–207.CrossRefPubMedGoogle Scholar
  32. 32.
    Mitsukawa K, Lu X, Bartfai T. Galanin, galanin receptors and drug targets. Cell Mol Life Sci CMLS. 2008;65(12):1796–805.CrossRefPubMedGoogle Scholar
  33. 33.
    Mathew SJ, Price RB, Charney DS. Recent advances in the neurobiology of anxiety disorders: implications for novel therapeutics. Am J Med Genet C Semin Med Genet. 2008;148(2):89–98.CrossRefGoogle Scholar
  34. 34.
    Forbes EE, Dahl RE. Pubertal development and behavior: hormonal activation of social and motivational tendencies. Brain Cogn. 2010;72(1):66–72.CrossRefPubMedGoogle Scholar
  35. 35.
    Fry AC, Schilling BK, Fleck SJ, Kraemer WJ. Relationships between competitive wrestling success and neuroendocrine responses. J Strength Cond Res. 2011;25(1):40–5.CrossRefPubMedGoogle Scholar
  36. 36.
    Mehta PH, Beer J. Neural mechanisms of the testosterone–aggression relation: the role of orbitofrontal cortex. J Cogn Neurosci. 2010;22(10):2357–68.CrossRefPubMedGoogle Scholar
  37. 37.
    Chichinadze K, Chichinadze N. Stress-induced increase of testosterone: contributions of social status and sympathetic reactivity. Physiol Behav. 2008;94(4):595–603.CrossRefPubMedGoogle Scholar
  38. 38.
    McHenry J, Carrier N, Hull E, Kabbaj M. Sex differences in anxiety and depression: role of testosterone. Front Neuroendocrinol. 2014;35(1):42–57.CrossRefPubMedGoogle Scholar
  39. 39.
    Zarrouf FA, Artz S, Griffith J, Sirbu C, Kommor M. Testosterone and depression: systematic review and meta-analysis. J Psychiatr Pract. 2009;15(4):289–305.CrossRefPubMedGoogle Scholar
  40. 40.
    Mehta PH, Josephs RA. Testosterone and cortisol jointly regulate dominance: evidence for a dual-hormone hypothesis. Horm Behav. 2010;58(5):898–906.CrossRefPubMedGoogle Scholar
  41. 41.
    Sonnenschein C, Soto AM. An updated review of environmental estrogen and androgen mimics and antagonists. J Steroid Biochem Mol Biol. 1998;65(1):143–50.CrossRefPubMedGoogle Scholar
  42. 42.
    Kirschbaum C, Hellhammer DH. Salivary cortisol in psychoneuroendocrine research: recent developments and applications. Psychoneuroendocrinology. 1994;19(4):313–33.CrossRefPubMedGoogle Scholar
  43. 43.
    Walf AA, Frye CA. A review and update of mechanisms of estrogen in the hippocampus and amygdala for anxiety and depression behavior. Neuropsychopharmacology. 2006;31(6):1097–111.CrossRefPubMedPubMedCentralGoogle Scholar
  44. 44.
    Hilke S, Holm L, Åman K, Hökfelt T, Theodorsson E. Rapid change of neuropeptide Y levels and gene-expression in the brain of ovariectomized mice after administration of 17β-estradiol. Neuropeptides. 2009;43(4):327–32.CrossRefPubMedGoogle Scholar
  45. 45.
    Hilke S, Theodorsson A, Fetissov S, Åman K, Holm L, Hökfelt T, Theodorsson E. Estrogen induces a rapid increase in galanin levels in female rat hippocampal formation−possibly a nongenomic/indirect effect. Eur J Neurosci. 2005;21(8):2089–99.CrossRefPubMedGoogle Scholar
  46. 46.
    Gogos A, Sbisa A, Sun J, van den Buuse M. Selective estrogen receptor modulators, raloxifene and tamoxifen, modulate dopaminergic activity: implications for schizophrenia. J Neurochem. 2015;134:187–96.Google Scholar
  47. 47.
    Pines A. Alzheimer's disease, menopause and the impact of the estrogenic environment. Climacteric. 2016;19(5):430–2.CrossRefPubMedGoogle Scholar
  48. 48.
    Bali A, Jaggi AS. Multifunctional aspects of allopregnanolone in stress and related disorders. Prog Neuro-Psychopharmacol Biol Psychiatry. 2014;48:64–78.CrossRefGoogle Scholar
  49. 49.
    Girdler SS, Klatzkin R. Neurosteroids in the context of stress: implications for depressive disorders. Pharmacol Ther. 2007;116:125–39.CrossRefPubMedPubMedCentralGoogle Scholar
  50. 50.
    Melcangi RC, Panzica GC. Allopregnanolone: state of the art. Prog Neurobiol. 2014;113:1–5.CrossRefPubMedGoogle Scholar
  51. 51.
    Lyons DM, Parker KJ. Stress inoculation induced indications of resilience in monkeys. J Trauma Stress. 2007;20:423–33.CrossRefPubMedGoogle Scholar
  52. 52.
    Lyons DM, Parker KJ, Katz M, Schatzberg AF. Developmental cascades linking stress inoculation, arousal regulation and resilience. Front Behav Neurosci. 2009;32(3):1–6.Google Scholar
  53. 53.
    McEwen BS, Morrison JH. The brain on stress: vulnerability and plasticity of the prefrontal cortex over the life course. Neuron. 2013;79(1):16–29.CrossRefPubMedPubMedCentralGoogle Scholar
  54. 54.
    Singh-Taylor A, Korosi A, Molet J, Gunn BG, Baram TZ. Synaptic rewiring of stress-sensitive neurons by early-life experience: a mechanism for resilience? Neurobiol Stress. 2015;1:109–15.CrossRefPubMedGoogle Scholar
  55. 55.
    Masten AS. Invited commentary: resilience and positive youth development frameworks in developmental science. J Youth Adolesc. 2014;43(6):1018–24.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  • Avinash De Sousa
    • 1
  • Amresh Shrivastava
    • 2
  • Charles B. Nemeroff
    • 3
    • 4
    • 5
    • 6
    • 7
    • 8
  1. 1.Department of PsychiatryLokmanya Tilak Municipal Medical CollegeMumbaiIndia
  2. 2.Lawson Health Research InstituteUniversity of Western OntarioLondonCanada
  3. 3.Department of Psychiatry and Behavioral SciencesUniversity of MiamiMiamiUSA
  4. 4.Center on AgingUniversity of MiamiMiamiUSA
  5. 5.Jackson Memorial Hospital, University of MiamiMiamiUSA
  6. 6.Department of PsychiatryUniversity of Miami Hospital, University of MiamiMiamiUSA
  7. 7.Department of Biochemistry and Molecular BiologyUniversity of MiamiMiamiUSA
  8. 8.Leonard M. Miller School of MedicineUniversity of MiamiMiamiUSA

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