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Bullous Diseases in Dark Skin

  • Anes Yang
  • Emily K. Kozera
  • Dédée F. Murrell
Chapter

Abstract

Blisters are commonly caused by injuries, in particular by burns or specific skin irritation, and heal relatively rapidly without leaving scars. However, a series of autoimmune disorders affecting the skin and the mucous membranes initiate the formation of antibodies against adhesion proteins in skin and mucosal membranes causing chronic and consistent blistering, occasionally leading to scars. The presence of autoantibodies in tissue is visible by direct immunofluorescence (DIF), and circulating autoantibodies may also occur and be detected. Several clinical entities characterized by bulla formation may then arise and also overlap (Table 28.1). The management of these bullous disorders is difficult, and, if left untreated, life-threatening conditions may result.

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Anes Yang
    • 1
  • Emily K. Kozera
    • 1
  • Dédée F. Murrell
    • 1
  1. 1.Department of DermatologySt. George Hospital, University of South WalesSydneyAustralia

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