The Heat Shock Protein-CD91 Pathway and Tumor Immunosurveillance

  • Robert J. Binder


The intracellular functions of HSPs have been well studied and delineate a clear role in the unfolded protein response. The functions of extracellular HSPs are only beginning to be appreciated. Specifically, extracellular localization of HSPs endorses the initiation of immune responses against aberrant cells. This chapter examines the role of extracellular HSPs, and the receptor CD91, in immunosurveillance of cancers. Although the concept of cancer immunosurveillance was described over 100 years ago, a molecular description of how the immune responses is initiated has been lacking. Incorporating the HSP-CD91 pathway into cancer immunosurveillance provides the first mechanism of how immune responses are primed.


Dendritic cell Chaperone Tumor immunity T regs 


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Authors and Affiliations

  1. 1.Department of ImmunologyUniversity of Pittsburgh School of MedicinePittsburghUSA

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