US-CT-MRI Findings: Staging-Response-Restaging of Bone and Soft Tissue Tumors
Primary malignant bone tumors are a rare and diverse group of tumors. Osteosarcoma is the commonest malignant neoplasm among the primary bone tumors (excluding multiple myeloma), accounting for 30% of all such malignancies. Soft tissue sarcomas are a rare (1% adult cancers and 6% of childhood cancers), heterogeneous group of malignant tumors that can affect any age and gender and are often highly aggressive. Soft tissue sarcomas occur in the extremities in about 50% of cases, with a predilection for the lower extremities (80%). Magnetic resonance imaging has the most important role in staging and characterizing all primary bone tumors. The primary goal of treatment is to achieve local control of the disease through a limb-salvage procedure; however, if the lesion is too advanced, an amputation or even disarticulation may be required. The decision depends on many factors such as tumor size, extracompartmental spread, and relationship to vessels, nerves, and joints. Identification of the compartments is very important in case of imaging-guided biopsy. Treatment of soft tissue and bone sarcomas requires a multidisciplinary team that includes radiologists, surgeons, and oncologists in order to provide optimal treatment with limb-preserving therapies.
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