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Spatiotemporal Analysis of Structural Changes of the Lamina Cribrosa

  • Charly Girot
  • Hiroshi Ishikawa
  • James Fishbaugh
  • Gadi Wollstein
  • Joel Schuman
  • Guido Gerig
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 10554)

Abstract

Glaucoma, a progressive and degenerative disease of the optic nerve, is the second leading cause of blindness worldwide. Mechanical deformation of the lamina cribrosa (LC) under high intraocular pressure (IOP) can lead to axonal death of optic nerve fibers. To explore the effect of pressure on the LC, we utilize an experimental setup where longitudinal 3D optical coherence tomography (OCT) images are acquired at different levels of IOP administered via a well-controlled external force. Structural changes are measured via image deformations which map all observed images simultaneously into a common coordinate space. These deformations encode local patterns of structural and volume change across the image sequence, resulting in quantification of the spatiotemporal deformation pattern of the LC due to variation of pressure. We also describe a 3D segmentation algorithm to restrict our deformation analysis separately to the beams or pores of the LC. A single case study demonstrates the potential of the proposed methodology for non-invasive in-vivo analysis of LC dynamics in individual subjects.

Keywords

OCT Lamina cribrosa Spatiotemporal analysis Glaucoma 

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Charly Girot
    • 1
  • Hiroshi Ishikawa
    • 2
  • James Fishbaugh
    • 1
  • Gadi Wollstein
    • 2
  • Joel Schuman
    • 2
  • Guido Gerig
    • 1
  1. 1.Tandon School of EngineeringNew York UniversityBrooklynUSA
  2. 2.Langone Medical Center, Department of OphtalmologyNYU School of MedicineNew YorkUSA

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