Whole Brain Parcellation with Pathology: Validation on Ventriculomegaly Patients
Numerous brain disorders are associated with ventriculomegaly; normal pressure hydrocephalus (NPH) is one example. NPH presents with dementia-like symptoms and is often misdiagnosed as Alzheimer’s due to its chronic nature and nonspecific presenting symptoms. However, unlike other forms of dementia NPH can be treated surgically with an over 80% success rate on appropriately selected patients. Accurate assessment of the ventricles, in particular its sub-compartments, is required to diagnose the condition. Existing segmentation algorithms fail to accurately identify the ventricles in patients with such extreme pathology. We present an improvement to a whole brain segmentation approach that accurately identifies the ventricles and parcellates them into four sub-compartments. Our work is a combination of patch-based tissue segmentation and multi-atlas registration-based labeling. We include a validation on NPH patients, demonstrating superior performance against state-of-the-art methods.
KeywordsBrain MRI Enlarged ventricles Hydrocephalus
This work was supported by the NIH/NINDS under grant R21-NS096497. Support was also provided by the National Multiple Sclerosis Society grant RG-1507-05243 and the Dept. of Defense Center for Neuroscience and Regenerative Medicine.
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