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Immunological Rare Diseases

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Rare Diseases Epidemiology: Update and Overview

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1031))

Abstract

The immune system is delegated to defend the body from attacks from outside or inside. Many diseases can affect immune system reducing its ability to defend self or inducing an abnormal response against external or internal antigens. Rare diseases affecting immune system present some issue in common with other rare diseases and some peculiarities due to the huge variability in the disease’s expression. However, a correct estimation of the epidemiology of rare disorders is necessary for evaluating the prognosis and the responses to new therapies, for planning proper public health services, and finally to establish fair and sustainable prices for innovative medicines. Due to the enormous number of different rare immunological diseases, in this chapter we are going to analyse some of them that can be considered paradigmatic of the various expressions of disease.

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Authors and Affiliations

  1. Department of Clinical and Biological Sciences, Turin University, Turin, Italy

    Simone Baldovino, Elisa Menegatti, Dario Roccatello & Savino Sciascia

  2. Center for Research of Immunopathology and Rare Diseases - Coordinating Center of the Piedmont and Aosta Valley Network for Rare Diseases, San Giovanni Bosco Hospital, piazza del donatore di Sangue 3, 10054, Turin, Italy

    Simone Baldovino, Dario Roccatello & Savino Sciascia

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  1. Simone Baldovino
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  2. Elisa Menegatti
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  3. Dario Roccatello
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  4. Savino Sciascia
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Correspondence to Simone Baldovino .

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Editors and Affiliations

  1. RDR and CIBERER, Instituto de Salud Carlos III, Madrid, Spain

    Manuel Posada de la Paz

  2. Centro Nazionale Malattie Rare, Istituto Superiore di Sanita, Roma, Italy

    Domenica Taruscio

  3. National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, USA

    Stephen C. Groft

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Baldovino, S., Menegatti, E., Roccatello, D., Sciascia, S. (2017). Immunological Rare Diseases. In: Posada de la Paz, M., Taruscio, D., Groft, S. (eds) Rare Diseases Epidemiology: Update and Overview. Advances in Experimental Medicine and Biology, vol 1031. Springer, Cham. https://doi.org/10.1007/978-3-319-67144-4_26

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