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Unknotted Strand Routings of Triangulated Meshes

  • Abdulmelik Mohammed
  • Mustafa Hajij
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 10467)

Abstract

In molecular self-assembly such as DNA origami, a circular strand’s topological routing determines the feasibility of a design to assemble to a target. In this regard, the Chinese-postman DNA scaffold routings of Benson et al. (2015) only ensure the unknottedness of the scaffold strand for triangulated topological spheres. In this paper, we present a cubic-time \(\frac{5}{3}-\)approximation algorithm to compute unknotted Chinese-postman scaffold routings on triangulated orientable surfaces of higher genus. Our algorithm guarantees every edge is routed at most twice, hence permitting low-packed designs suitable for physiological conditions.

Keywords

DNA origami Knot theory Graph theory Chinese postman problem 

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Aalto UniversityEspooFinland
  2. 2.University of South FloridaTampaUSA

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