DNA-Templated Synthesis Optimization

  • Bjarke N. Hansen
  • Kim S. LarsenEmail author
  • Daniel MerkleEmail author
  • Alexei Mihalchuk
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 10467)


In chemistry, synthesis is the process in which a target compound is produced in a step-wise manner from given base compounds. A recent, promising approach for carrying out these reactions is DNA-templated synthesis, since, as opposed to more traditional methods, this approach leads to a much higher effective molarity and makes much desired one-pot synthesis possible. With this method, compounds are tagged with DNA sequences and reactions can be controlled by bringing two compounds together via their tags. This leads to new cost optimization problems of minimizing the number of different tags or strands to be used under various conditions. We identify relevant optimization criteria, provide the first computational approach to automatically inferring DNA-templated programs, and obtain optimal and near-optimal results.



The second and third authors were supported in part by the Danish Council for Independent Research, Natural Sciences, grants DFF-1323-00247 and DFF-7014-00041.


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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Department of Mathematics and Computer ScienceUniversity of Southern DenmarkOdenseDenmark

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