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Combination Treatment of Mesenchymal Stem Cells (MSCs) and Angelica sinensis’ Active Ingredients for Ischemic Stroke

  • Qian Zhang
  • Yonghua ZhaoEmail author
Chapter
Part of the Springer Series in Translational Stroke Research book series (SSTSR)

Abstract

At present, mesenchymal stem cells (MSCs) are regarded as a candidate for neovascularization and tissue regeneration after ischemic stroke. Numerous studies reported that Angelica (also called Dong quai, a well-known Chinese herbal medicine) extracts and its active ingredients such as ligustilide, n-Butylphthalide and sodium ferulate had significant effects of anti-inflammatory, anti-activation of oxygen free radicals, angiogenesis, anti-platelet aggregation, neuroprotection and so on. Angelica’ active compositions facilitated MSCs to migrate into infarcted zone and differentiation. Moreover, MSCs combined with angelica’ active components improved neurological function and decreased infarcted volume, advanced neovascularization and neurogenesis, regulated astrocytes characteristics, enhanced regional cerebral blood flow and glucose metabolism, as well as reduced brain-blood barrier permeability in infarction. Consequently, the structure and function of neurovascular unit in infarct region partly obtained recovery. Therefore, the combination treatment was a valuable therapy aimed at improving post-stroke restoration.

Keywords

Angelica sinensis Combination treatment Ischemic stroke Mesenchymal stem cells 

Abbreviations

BBB

Blood-brain barrier

BDNF

Brain-derived neurotrophic factor

BMP

Bone morphogenetic proteins

BP

n-Butylidenephthalide

BrdU

5-Bromo-2′-deoxyuridine

CBF

Cerebral blood flow

CXCR4

Chemokine (CXC motif) receptor-4

DCX

Doublecortin

DG

Dentate gyrus

EC

Endothelial cell

ERK

Extracellular signal-regulated kinases

FA

Ferulic acid

FDA

Food and Drug Administration

FDG

18F-2-deoxy-glucose

GDNF

Glial cell line-derived neurotrophic factor

GFAP

Glial fibrillary acidic protein

HIF

Hypoxia-inducible factors

HUVEC

Human umbilical vein endothelial cell

MCAo

Middle cerebral artery occlusion

MRI

Magnetic resonance imaging

MSC

Mesenchymal stem cell

mTOR

Mammalian target of rapamycin

NBP

n-Butylphthalide

PET/CT

Positron emission tomography–computed tomography

PWI

Perfusion-weighted imaging

SDF-1

Stromal cell-derived factor-1

SF

Sodium ferulate

STEPS

Stem Cells as an Emerging Paradigm in Stroke

SVZ

Subventricular zone

TTC

2,3,5-Triphenyltetrazolium chloride

Tuj-1

Neuron-specific class III beta-tubulin

VEGF

Vascular endothelial growth factor

vWF

Von Willebrand factor

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.State Key Laboratory of Quality Research in Chinese Medicine, Faculty of Chinese MedicineMacau University of Science and TechnologyMacauChina

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