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Improving Functional MRI Registration Using Whole-Brain Functional Correlation Tensors

  • Yujia Zhou
  • Pew-Thian Yap
  • Han Zhang
  • Lichi Zhang
  • Qianjin FengEmail author
  • Dinggang ShenEmail author
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 10433)

Abstract

Population studies of brain function with resting-state functional magnetic resonance imaging (rs-fMRI) largely rely on the accurate inter-subject registration of functional areas. This is typically achieved through registration of the corresponding T1-weighted MR images with more structural details. However, accumulating evidence has suggested that such strategy cannot well-align functional regions which are not necessarily confined by the anatomical boundaries defined by the T1-weighted MR images. To mitigate this problem, various registration algorithms based directly on rs-fMRI data have been developed, most of which have utilized functional connectivity (FC) as features for registration. However, most of the FC-based registration methods usually extract the functional features only from the thin and highly curved cortical grey matter (GM), posing a great challenge in accurately estimating the whole-brain deformation field. In this paper, we demonstrate that the additional useful functional features can be extracted from brain regions beyond the GM, particularly, white-matter (WM) based on rs-fMRI, for improving the overall functional registration. Specifically, we quantify the local anisotropic correlation patterns of the blood oxygenation level-dependent (BOLD) signals, modeled by functional correlation tensors (FCTs), in both GM and WM. Functional registration is then performed based on multiple components of the whole-brain FCTs using a multichannel Large Deformation Diffeomorphic Metric Mapping (mLDDMM) algorithm. Experimental results show that our proposed method achieves superior functional registration performance, compared with other conventional registration methods.

Keywords

Resting-state fMRI Registration LDDMM 

Notes

Acknowledgement

This work was supported in part by NIH grants NS093842 and EB022880.

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Guangdong Provincial Key Laboratory of Medical Image Processing, School of Biomedical EngineeringSouthern Medical UniversityGuangzhouChina
  2. 2.Department of Radiology, Biomedical Research Imaging Center (BRIC)University of North Carolina at Chapel HillChapel HillUSA

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