GSplit LBI: Taming the Procedural Bias in Neuroimaging for Disease Prediction

  • Xinwei Sun
  • Lingjing HuEmail author
  • Yuan YaoEmail author
  • Yizhou Wang
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 10435)


In voxel-based neuroimage analysis, lesion features have been the main focus in disease prediction due to their interpretability with respect to the related diseases. However, we observe that there exist another type of features introduced during the preprocessing steps and we call them “Procedural Bias”. Besides, such bias can be leveraged to improve classification accuracy. Nevertheless, most existing models suffer from either under-fit without considering procedural bias or poor interpretability without differentiating such bias from lesion ones. In this paper, a novel dual-task algorithm namely GSplit LBI is proposed to resolve this problem. By introducing an augmented variable enforced to be structural sparsity with a variable splitting term, the estimators for prediction and selecting lesion features can be optimized separately and mutually monitored by each other following an iterative scheme. Empirical experiments have been evaluated on the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database. The advantage of proposed model is verified by improved stability of selected lesion features and better classification results.


Voxel-based structural magnetic resonance imaging Procedural bias Split Linearized Bregman Iteration Feature selection 



This work was supported in part by 973-2015CB351800, 2015CB85600, 2012CB825501, NSFC-61625201, 61370004, 11421110001 and Scientific Research Common Program of Beijing Municipal Commission of Education (No. KM201610025013).

Supplementary material

455908_1_En_13_MOESM1_ESM.pdf (802 kb)
Supplementary material 1 (pdf 802 KB)


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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.School of Mathematical SciencePeking UniversityBeijingChina
  2. 2.Yanjing Medical CollegeCapital Medical UniversityBeijingChina
  3. 3.Hong Kong University of Science and TechnologyHong KongHong Kong
  4. 4.Peking UniversityBeijingChina
  5. 5.National Engineering Laboratory for Video Technology, Key Laboratory of Machine Perception, School of EECSPeking UniversityBeijingChina

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