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Peptides as Bio-inspired Molecular Electronic Materials

  • John HorsleyEmail author
  • Jingxian Yu
  • Yuan Qi Yeoh
  • Andrew Abell
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1030)

Abstract

Understanding the electronic properties of single peptides is not only of fundamental importance to biology, but it is also pivotal to the realization of bio-inspired molecular electronic materials. Natural proteins have evolved to promote electron transfer in many crucial biological processes. However, their complex conformational nature inhibits a thorough investigation, so in order to study electron transfer in proteins, simple peptide models containing redox active moieties present as ideal candidates. Here we highlight the importance of secondary structure characteristic to proteins/peptides, and its relevance to electron transfer. The proposed mechanisms responsible for such transfer are discussed, as are details of the electrochemical techniques used to investigate their electronic properties. Several factors that have been shown to influence electron transfer in peptides are also considered. Finally, a comprehensive experimental and theoretical study demonstrates that the electron transfer kinetics of peptides can be successfully fine tuned through manipulation of chemical composition and backbone rigidity. The methods used to characterize the conformation of all peptides synthesized throughout the study are outlined, along with the various approaches used to further constrain the peptides into their geometric conformations. The aforementioned sheds light on the potential of peptides to one day play an important role in the fledgling field of molecular electronics.

Keywords

Peptides Electron transfer Bio-inspired Molecular electronics Electronic materials Electrochemical methods 

Notes

Acknowledgements

This work is supported by the ARC Centre of Excellence for Nanoscale BioPhotonics (CNBP). The authors also gratefully acknowledge the assistance of the Australian National Fabrication Facility (ANFF).

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • John Horsley
    • 1
    Email author
  • Jingxian Yu
    • 1
  • Yuan Qi Yeoh
    • 1
  • Andrew Abell
    • 1
  1. 1.ARC Centre of Excellence for Nanoscale BioPhotonics (CNBP), School of Chemistry and PhysicsThe University of AdelaideAdelaideAustralia

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