Programmable Bio-surfaces for Biomedical Applications

  • Kiyotaka ShibaEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1030)


A peptide can be used as a functional building block to construct artificial systems when it has sufficient transplantability and functional independence in terms of its assigned function. Recent advances in in vitro evolution systems have been increasing the list of peptides that specifically bind to certain targets, such as proteins and cells. By properly displaying these peptides on solid surfaces, we can endow the inorganic materials with various biological functions, which will contribute to the development of diagnosis and therapeutic medical devices. Here, the methods for the peptide-based surface functionalization are reviewed by focusing on sources of peptides as well as methods of immobilization.


Peptide aptamer In vitro evolution Artificial peptide Motif programing Material surface Diagnostic Exosome 


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© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Division of Protein EngineeringThe Cancer Institute of Japanese Foundation for Cancer ResearchTokyoJapan

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