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Nail Reactions to Anticancer Therapies

  • Marisa Kardos Garshick
  • Patricia L. Myskowski
Chapter

Abstract

Anticancer therapies, including cytotoxic chemotherapies and targeted biologic therapies are well known to cause adverse reactions in the skin. The effect of anticancer treatments on the nails has only recently been appreciated. Although the nail changes are often asymptomatic, they can be associated with pain or functional impairment. Many of the cytotoxic chemotherapies result in changes to the nail bed or nail plate, while the newer targeted therapies tend to affect the periungual region. This chapter highlights how to recognize and manage the nail changes seen with cytotoxic chemotherapies as well as targeted therapies.

Keywords

Chemotherapy Targeted therapy Epidermal growth factor receptor inhibitors Taxanes Oncology Cutaneous side effects Adverse effects Nails Nail toxicity Melanonychia Pyogenic granuloma Paronychia Onycholysis Beau’s lines Frozen gloves 

Supplementary material

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Patient Handout (PDF 36 kb)

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Marisa Kardos Garshick
    • 1
  • Patricia L. Myskowski
    • 2
  1. 1.New York Presbyterian/Weill Cornell MedicineNew YorkUSA
  2. 2.Memorial Sloan-Kettering Cancer Center, Weill Cornell MedicineNew YorkUSA

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