Nails in Systemic Disease

  • Shari R. LipnerEmail author
  • Monica Lawry
  • George Kroumpouzos
  • Richard K. Scher
  • C. Ralph DanielIII


Nails abnormalities can be readily examined by dermatologists and may be the first indication that there is an underlying systemic disease. Splinter hemorrhages are usually due to trauma, but subacute bacterial endocarditis is another possible cause. Leukonychia is more specifically associated with systemic disease, and examples include half and half nails, Terry’s nails, and Muehrke’s lines. In yellow nail syndrome, there is a classic triad of thick and yellow nails with increased transverse curvature, absent cuticles, and slow growth rate, as well as, lymphedema, and respiratory tract involvement. Nails changes are common in pregnancy, specifically increased transverse curvature, and brittleness.


Nails Systemic disease Pregnancy HIV Genodermatoses Rheumatologic conditions Leukonychia Splinter hemorrhages Beau’s lines Pitting Koilonychia Clubbing 

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Shari R. Lipner
    • 1
    Email author
  • Monica Lawry
    • 2
  • George Kroumpouzos
    • 3
    • 4
  • Richard K. Scher
    • 5
  • C. Ralph DanielIII
    • 6
  1. 1.Department of DermatologyWeill Cornell MedicineNew YorkUSA
  2. 2.Department of DermatologySutter Medical GroupDavisUSA
  3. 3.Alpert Medical School of Brown UniversityProvidenceUSA
  4. 4.GK Dermatology, PCSouth WeymouthUSA
  5. 5.Weill Cornell Medicine/DermatologyNew York HospitalNew YorkUSA
  6. 6.University of Mississippi Medical Center, Dermatology & Surgery of the SkinJacksonUSA

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