Logopenic Primary Progressive Aphasia

  • Michael J. Hoch
  • Lev Bangiyev
  • Timothy M. Shepherd


Logopenic primary progressive aphasia is an atypical variant of Alzheimer’s disease characterized by decreased rate of spontaneous language production. PET/MR imaging demonstrates cortical atrophy and corresponding hypometabolism, typically most severe in the left lateral temporoparietal region.


Logopenic primary progressive aphasia PET/MR FDG Hypometabolism Language 

Suggested Reading

  1. Henry ML, Gorno-Tempini ML. The logopenic variant of primary progressive aphasia. Curr Opin Neurol. 2010;23(6):633–7.CrossRefPubMedPubMedCentralGoogle Scholar
  2. Leyton CE, Villemagne VL, Savage S, Pike KE, Ballard KJ, Piguet O, et al. Subtypes of progressive aphasia: application of the international consensus criteria and validation using β-amyloid imaging. Brain. 2011;134:3030–43.CrossRefPubMedGoogle Scholar
  3. Madhavan A, Whitwell JL, Weigand SD, Duffy JR, Strand EA, Machulda MM, et al. FDG PET and MRI in logopenic primary progressive aphasia versus dementia of the Alzheimer's type. PLoS One. 2013;8(4):e62471.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Michael J. Hoch
    • 1
  • Lev Bangiyev
    • 2
  • Timothy M. Shepherd
    • 3
  1. 1.Department of Radiology and Imaging SciencesEmory University HospitalAtlantaUSA
  2. 2.Department of RadiologyStony Brook University HospitalStony BrookUSA
  3. 3.Department of RadiologyNew York University Langone Medical CenterNew YorkUSA

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