Real-Time Calibration of a Feedback Trap

  • Momčilo GavrilovEmail author
Part of the Springer Theses book series (Springer Theses)


Feedback traps use closed-loop control to trap or manipulate small particles and molecules in solution. They have been applied to the measurement of physical and chemical properties of particles and to explore fundamental questions in the non-equilibrium statistical mechanics of small systems. These applications have been hampered by drifts in the electric forces used to manipulate the particles. Although the drifts are small for measurements on the order of seconds, they dominate on time scales of minutes or slower. Here, we show that a recursive maximum likelihood (RML) algorithm can allow real-time measurement and control of electric and stochastic forces over time scales of hours. Simulations show that the RML algorithm recovers known parameters accurately. Experimental estimates of diffusion coefficients are also consistent with expected physical properties.


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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Department of Biophysics and Biophysical ChemistryJohns Hopkins UniversityBaltimoreUSA

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