ROS Signaling in the Pathogenesis of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS)

  • Manuela Kellner
  • Satish Noonepalle
  • Qing Lu
  • Anup Srivastava
  • Evgeny Zemskov
  • Stephen M. BlackEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 967)


The generation of reactive oxygen species (ROS) plays an important role for the maintenance of cellular processes and functions in the body. However, the excessive generation of oxygen radicals under pathological conditions such as acute lung injury (ALI) and its most severe form acute respiratory distress syndrome (ARDS) leads to increased endothelial permeability. Within this hallmark of ALI and ARDS, vascular microvessels lose their junctional integrity and show increased myosin contractions that promote the migration of polymorphonuclear leukocytes (PMNs) and the transition of solutes and fluids in the alveolar lumen. These processes all have a redox component, and this chapter focuses on the role played by ROS during the development of ALI/ARDS. We discuss the origins of ROS within the cell, cellular defense mechanisms against oxidative damage, the role of ROS in the development of endothelial permeability, and potential therapies targeted at oxidative stress.


Lung injury Pulmonary endothelial cell Reactive oxygen species Xanthine oxidase Nitric oxide synthase Mitochondrial respiratory chain Cytochrome P450 NADPH oxidase Superoxide dismutase Catalase Glutathione Polymorphonuclear leukocytes 


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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Manuela Kellner
    • 1
  • Satish Noonepalle
    • 1
  • Qing Lu
    • 1
  • Anup Srivastava
    • 1
  • Evgeny Zemskov
    • 1
  • Stephen M. Black
    • 1
    Email author
  1. 1.Department of MedicineCenter for Lung Vascular Pathobiology, University of ArizonaTucsonUSA

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