Cannabis Dependence

  • H. Thomas Milhorn


Cannabis is a genus of flowering plant that includes three species—sativa, indica, and ruderalis. Cannabis sativa and Cannabis indica products are used recreationally and as a source of fiber. Cannabis ruderalis is a species of Cannabis originating in Central Russia. It is less common than the other species of Cannabis. It has a lower THC content than the other two, so it is rarely grown for recreational use. Its much shorter stature (about 2 ft) limits its application for hemp production. It is used traditionally in Russian and Mongolian folk medicine, especially for the treatment of depression.


Marijuana Pharmacology Interactions Health risks Medical use Medical marijuana Cannabis indica Spice Hashish Hash oil Tolerance Dependence Abstinence syndrome Overdose 


  1. 1.
    London D. What is Cannabis Ruderalis? May 12, 2016.
  2. 2.
    O’Brien R, Cohen S. The encyclopedia of drug abuse. New York: Facts on File; 1984.Google Scholar
  3. 3.
  4. 4.
    Edible marijuana creates new cautions for a safe Halloween. McCook Gazette. October 31, 2016.
  5. 5.
    National survey on drug use and health: trends in prevalence of various drugs for ages 12 or older, ages 12 to 17, ages 18 to 25, and ages 26 or older. National Institute on Drug Abuse (NIDA). 2015.
  6. 6.
    Marijuana. Partnership for Drug-Free Kids. 2017.
  7. 7.
    Marijuana: What is the scope of marijuana use in the United States? National Institute on Drug Abuse (NIDA). November, 2016.Google Scholar
  8. 8.
    Dubuc B. The brain from top to bottom. McGill University. May 2012.
  9. 9.
    Ashton CH. Pharmacology and effects of cannabis: a brief review. Br J Psychiatry. 2001;178(2):101–6.CrossRefPubMedGoogle Scholar
  10. 10.
    Schwartz RH, Hawks RL. Laboratory detection of marijuana use. J Am Med Assoc. 1981;254:788–92.CrossRefGoogle Scholar
  11. 11.
    Milhorn HT. Chemical dependence: diagnosis, treatment, and prevention. New York: Springer; 1990.CrossRefGoogle Scholar
  12. 12.
    Schwartz RH. Marijuana: an overview. Pediatr Clin N Am. 1987;34:305–17.CrossRefGoogle Scholar
  13. 13.
    Wilford BB, editor. Major drugs of abuse. In: Drug abuse: a guide for the primary care physician. Chicago: American Medical Association; 1981.p. 21–84.Google Scholar
  14. 14.
    Marijuana (Cannabis Sativa). Mayo Clinic. November 1, 2013.
  15. 15.
    Council on Scientific Affairs. Marijuana: its health hazards and therapeutic potentials. JAMA. 1981; 246:1823–7.Google Scholar
  16. 16.
    Galli JA, Sawaya RA, Friedenberg FK. Cannabinoid hyperemesis syndrome. Curr Drug Abuse Rev. 2011;4(4):241–9.CrossRefPubMedPubMedCentralGoogle Scholar
  17. 17.
    Morris RR. Human pulmonary pathophysiology changes from marijuana smoking. J Forensic Sci. 1985;30:345–9.CrossRefPubMedGoogle Scholar
  18. 18.
    Russo L. Cannabinoid poisoning. Medscape. June 24, 2016.
  19. 19.
    Wu TC, Tashkin DP, Djahed B, Rose JE. Pulmonary hazards of smoking marijuana as compared with tobacco. N Engl J Med. 1988;318:347–51.CrossRefPubMedGoogle Scholar
  20. 20.
    What are the long-term effects of marijuana? VeryWell. July 17, 2016.
  21. 21.
    Thompson D. Fatal car crashes involving pot use have tripled in U.S., study finds. WebMD. February 4, 2014.
  22. 22.
    Macaluso M. 3 prescription drugs that come from marijuana. USA Today, March 17, 2014.Google Scholar
  23. 23.
  24. 24.
    Marijuana. Center for Substance Abuse Research (CESAR)/University of Maryland.
  25. 25.
    Anderson, L. Synthetic marijuana – spice or K2.
  26. 26.
    What are synthetic cannabinoids?. National Institute on Drug Abuse (NIDA). November 2015.Google Scholar
  27. 27.
    Rael A. What is synthetic marijuana and how does it compare to traditional marijuana? The Huffington Post, September 11, 2013.Google Scholar
  28. 28.
  29. 29.
    What is Hashish? Weed Street Journal. March 7, 2011.
  30. 30.
    Hash oil. WeedWiki. September 28, 2015.
  31. 31.
    Dangerous new marijuana product looks like lip balm, packs big kick. Fox News/Health, August 17, 2014.Google Scholar
  32. 32.
    Hunt A, Jones RT. Tolerance and disposition of tetrahydrocannabinol in man. J Pharmacol Exp Ther. 1980;215:35–44.PubMedGoogle Scholar
  33. 33.
    Is marijuana addictive? National Institute on Drug Abuse (NIDA). January 2017.Google Scholar
  34. 34.
    Medina J. Cannabis (marijuana) withdrawal. PsychCentral. February 9, 2017.

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • H. Thomas Milhorn
    • 1
    • 2
  1. 1.East Central HealthNet Family Medicine Residency ProgramMeridianUSA
  2. 2.University of Mississippi School of MedicineJacksonUSA

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