Vitiligo pp 163-167 | Cite as

Vitiligo-Like Lesions in Patients with Metastatic Melanoma Receiving Immunotherapies

  • Katia Boniface
  • Julien SeneschalEmail author


The development of immunotherapies has remarkably improved the efficacy of treatment of patients with metastatic melanoma, as observed for example with immune checkpoint therapies targeting cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) or programmed cell death-1 (PD-1). Nonetheless, reinstatement of an effective antitumor immune response also contributes to the development of immune-related adverse events, including vitiligo-like depigmentation. This review aims to discuss special considerations in vitiligo-like lesions occurring in patients receiving anti-PD-1 therapies from a clinical and physiopathological perspective.


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.1INSERM U1035, BMGIC, Immuno-dermatology teamUniversity of BordeauxBordeauxFrance
  2. 2.Department of Dermatology and Pediatric DermatologyNational Reference Center for Rare Skin Diseases, Saint-André Hospital, University of BordeauxBordeauxFrance

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