This chapter will discuss epidemiology, workup, and management of nasopharyngeal cancer.
KeywordsNasopharyngeal cancer Radiation therapy Chemoradiation
We thank Gautam Prasad, MD, PhD; James Rembert, MD; and Eric K. Hansen, MD, for their work on the prior edition of this chapter.
- Chan AT, Teo PM, Leung TW, Leung SF, Lee WY, Yeo W, Choi PH, Johnson PJ. A prospective randomized study of chemotherapy adjunctive to definitive radiotherapy in advanced nasopharyngeal carcinoma. International Journal of Radiation Oncology. Biology. Physics. 1995 Oct 15;33(3):569–77.CrossRefGoogle Scholar
- Chen L, et al. Concurrent chemoradiotherapy plus adjuvant chemotherapy versus concurrent chemoradiotherapy alone in patients with locoregionally advanced nasopharyngeal carcinoma: a phase 3 multicentre randomised controlled trial. Lancet Oncol. 2012; 13(2):163–71. Available at: https://doi.org/10.1016/S1470-2045(11)70320-5.
- Chua DT, Sham JS, Choy D, et al. Preliminary report of the Asian-Oceanian clinical oncology association randomized trial comparing cisplatin and epirubicin followed by radiotherapy versus radiotherapy alone in the treatment of patients with locoregionally advanced nasopharyngeal carcinoma. Cancer. 1998;83:2270–83.CrossRefPubMedGoogle Scholar
- Garden AS. The nasopharynx. In: Cox JD, Ang KK, editors. Radiation oncology: rationale, technique, results. 8th ed. St. Louis: Mosby; 2003. p. 178–95.Google Scholar
- International Nasopharynx Cancer Study Group. Preliminary results of a randomized trial comparing neoadjuvant chemotherapy (cisplatin, epirubicin, bleomycin) plus radiotherapy vs. radiotherapy alone in stage IV (≥ N2, M0) undifferentiated nasopharyngeal carcinoma: a positive effect on progression-free survival. Int J Radiat Oncol Phys. 1996;35:463–9.CrossRefGoogle Scholar
- Lee AWM, et al. Preliminary results of trial NPC-0501 evaluating the therapeutic gain by changing from concurrent-adjuvant to induction-concurrent chemoradiotherapy, changing from fluorouracil to capecitabine, and changing from conventional to accelerated radiotherapy fr. Cancer. 2015;121(8):1328–38.CrossRefPubMedGoogle Scholar
- Pow EH, Kwong DL, McMillan AS, et al. Xerostomia and quality of life after intensity-modulated radiotherapy vs. conventional radiotherapy for early-stage nasopharyngeal carcinoma: initial report on a randomized controlled clinical trial. Int J Radiat Oncol Biol Phys. 2006;66:981–91.CrossRefPubMedGoogle Scholar
- Wee J, Tan EH, Tai BC, et al. Randomized trial of radiotherapy versus concurrent chemo-radiotherapy followed by adjuvant chemotherapy in patients with American Joint Committee on Cancer/International Union Against Cancer Stage III and IV nasopharyngeal cancer of the endemic variety. J Clin Oncol. 2005;23:6730–8.CrossRefPubMedGoogle Scholar
© Springer International Publishing AG, part of Springer Nature 2018