Bone Tumors

  • Lauren Boreta
  • Steve E. Braunstein


This chapter will discuss radiotherapy for the treatment of bone tumors including osteosarcoma, chondrosarcoma, chordoma, and giant cell tumor.


Bone Osteosarcoma Chondrosarcoma 



We thank Tania Kaprealian MD; Brian Lee MD, PhD; and Jean L. Nakamura MD for their work on the prior edition of this chapter.


  1. Bloch OG, Jian BJ, Yang I, et al. Cranial Chondrosarcoma and recurrence. Skull Base. 2010;20:149–56.CrossRefGoogle Scholar
  2. Catton C, O’Sullivan B, et al. Chordoma: long term follow-up after radical photon irradiation. Radiother Oncol. 1996;41(1):p67–72.CrossRefGoogle Scholar
  3. Carpentier A, et al. Suboccipital and cervical chordomas: the value of aggressive treatment at first presentation of the disease. J Neurosurg. 2002;97(5):1070–7.CrossRefGoogle Scholar
  4. DeLaney TF, Park L, Goldberg SI, et al. Radiotherapy for local control of osteosarcoma. Int J Radiat Oncol Biol Phys. 2005;61:492–8.CrossRefGoogle Scholar
  5. DeLaney TF, et al. Long term results of phase II study of high dose photon/proton radiotherapy in the management of spine chordomas, chondrosarcomas and other sarcomas. J Surg Oncol. 2014;110(2):115–22.CrossRefGoogle Scholar
  6. Di Maio S, Temkin N, Ramanathan D, Sekhar L. Current comprehensive management of cranial base chordomas: 10-year meta-analysis of observational studies. J Neurosurg. 2011;115:1094–105.CrossRefGoogle Scholar
  7. Eilber F, Giuliano A, Eckardt J, et al. Adjuvant chemotherapy for osteosarcoma: a randomized prospective trial. J Clin Oncol. 1987;5:21–6.CrossRefGoogle Scholar
  8. Imai R, Kamada T, et al. Effect of carbon ion radiotherapy for sacral chordoma: results of a phase I-II and phase II clinical trials. Int J Radiat Oncol Biol Phys. 2010;77(5):1470–6.CrossRefGoogle Scholar
  9. Link MP, Goorin AM, Miser AW, et al. The effect of adjuvant chemotherapy on relapse-free survival in patients with osteosarcoma of the extremity. N Engl J Med. 1986;314:1600–6.CrossRefGoogle Scholar
  10. Machak GN, Tkachev SI, Solovyev YN, et al. Neoadjuvant chemotherapy and local radiotherapy for high-grade osteosarcoma of the extremities. Mayo Clin Proc. 2003;78:147–55.CrossRefGoogle Scholar
  11. Ozaki T, Flege S, Kevric M, et al. Osteosarcoma of the pelvis: experience of the cooperative osteosarcoma study group. J Clin Oncol. 2003;21:334–41.CrossRefGoogle Scholar
  12. Wagner TD, Kobayashi W, Dean S, et al. Combination short-course preoperative irradiation, surgical resection, and reduced-field high-dose postoperative irradiation in the treatment of tumors involving the bone. Int J Radiat Oncol Biol Phys. 2009;73:259–66.CrossRefGoogle Scholar
  13. Yamada Y, Laufer I, et al. Preliminary results of high dose single fraction radiotherapy for the management of chordomas of the spine and sacrum. Neurosurgery. 2013;73(4):673–80.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Radiation OncologyUniversity of California San FranciscoSan FranciscoUSA

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