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Takotsubo Syndrome and Cancer

  • Joaquim Cevallos
  • Alexander Lyon
Chapter

Abstract

Takotsubo Syndrome (TTS) is defined by transient ventricular dysfunction in the absence of culprit obstructive coronary artery disease. During acute presentation, patients present with typical ECG, echocardiographic and cardiac magnetic resonance imaging features. We present two cases of TTS in the context of cancer, with a wide range of complimentary tests, and then briefly discuss the pathophysiology and clinical presentation of TTS, highlighting the importance of appropriate management of TTS both during the acute phase and follow-up. The association between TTS and cancer is mentioned, with the possibility, in some cases, that TTS represents a paraneoplastic syndrome.

Keywords

Takotsubo syndrome Stress cardiomyopathy Heart failure Prolonged QT Metastatic cancer Chemotherapy 

References

  1. 1.
    Lyon AR, et al. Current state of knowledge on Takotsubo syndrome: a position statement from the task force on Takotsubo syndrome of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail. 2016;18:8–27.CrossRefGoogle Scholar
  2. 2.
    El-Sayed AM, et al. Demographic and co-morbid predictors of stress (Takotsubo) cardiomyopathy. Am J Cardiol. 2012;110:1368–72.CrossRefPubMedGoogle Scholar
  3. 3.
    Akashi YJ, et al. Epidemiology and pathophysiology of Takotsubo syndrome. Nat Rev Cardiol. 2015;12(7):387–97.CrossRefGoogle Scholar
  4. 4.
    Lyon AR, et al. Stress (Takotsubo) cardiomyopathy—a novel pathophysiological hypothesis to explain catecholamine-induced acute myocardial stunning. Nat Clin Pract Cardiovasc Med. 2008;5(1):22–9.CrossRefGoogle Scholar
  5. 5.
    Singh K, et al. Meta-analysis of clinical correlates of acute mortality in Takotsubo cardiomyopathy. Am J Cardiol. 2014;113:1420–8.CrossRefPubMedGoogle Scholar
  6. 6.
    Isogai T, et al. Out-of-hospital versus in-hospital Takotsubo cardiomyopathy: analysis of 3719 patients in the Diagnosis Procedure Combination database in Japan. Int J Cardiol. 2014;176:413–7.CrossRefPubMedGoogle Scholar
  7. 7.
    Morley-Smith AC, et al. Challenges of chronic cardiac problems in survivors of Takotsubo Syndrome. Heart Fail Clin. 2016;12(4):551–7.CrossRefPubMedGoogle Scholar
  8. 8.
    Burgdof C, et al. Long-term prognosis of the transient left ventricular dysfunction syndrome (Tako-Tsubo cardiomyopathy): focus on malignancies. Eur J Heart Fail. 2008;10(10):1015–9.CrossRefGoogle Scholar
  9. 9.
    Best L, et al. Microwave ablation of pulmonary metastases associated with perioperative Takotsubo cardiomyopathy. J Vasc Interv Radiol. 2014;25(7):1139–41.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Cardio-Oncology Service, Royal Brompton HospitalLondonUK
  2. 2.Imperial CollegeLondonUK

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