Takotsubo Syndrome (TTS) is defined by transient ventricular dysfunction in the absence of culprit obstructive coronary artery disease. During acute presentation, patients present with typical ECG, echocardiographic and cardiac magnetic resonance imaging features. We present two cases of TTS in the context of cancer, with a wide range of complimentary tests, and then briefly discuss the pathophysiology and clinical presentation of TTS, highlighting the importance of appropriate management of TTS both during the acute phase and follow-up. The association between TTS and cancer is mentioned, with the possibility, in some cases, that TTS represents a paraneoplastic syndrome.
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