Pericardial Disease, Constrictive Pericarditis and Restrictive Cardiomyopathy in Patients with Cancer

  • Saamir A. HassanEmail author
  • Poojita Shivamurthy
  • Syed Wamique Yusuf


Pericardial disease, specifically acute pericarditis, constrictive pericarditis, and pericardial tamponade, are seen in cancer patients due to the malignant process or from radiation therapy. In this chapter we present an overview of acute pericarditis, constrictive pericarditis and pericardial tamponade. We also discuss restrictive cardiomyopathy and its differences from constrictive pericarditis.


Pericardial disease Cardiac tamponade Constrictive heart disease Restrictive heart disease 


  1. 1.
    Fruergaard P, Launbjerg J, Hesse B, et al. The diagnoses of patients admitted with acute chest pain but without myocardial infarction. Eur Heart J. 1996;17(7):1028–34.CrossRefPubMedGoogle Scholar
  2. 2.
    Yusuf SW, Hassan SA, Mouhayar E, et al. Pericardial disease: a clinical review. Expert Rev Cardiovasc Ther. 2016;14(4):525–39.CrossRefPubMedGoogle Scholar
  3. 3.
    Adler Y, Charron P, et al. 2015 ESC guidelines for the diagnosis and management of pericardial diseases: the task force for the diagnosis and management of pericardial diseases of the European Society of Cardiology (ESC) endorsed by: the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J. 2015;36(42):2921–64.CrossRefPubMedGoogle Scholar
  4. 4.
    Imazio M, Demichelis B, Cecchi E, et al. Cardiac troponin I in acute pericarditis. J Am Coll Cardiol. 2003;42(12):2144–8.CrossRefPubMedGoogle Scholar
  5. 5.
    O’Gara PT, Kushner FG, Ascheim DD, et al. 2013 ACC/AHA guideline for the management of ST-elevation myocardial infarction. Circulation. 2013;127(4):e362–425.CrossRefPubMedGoogle Scholar
  6. 6.
    Ling LH, Jae KO, et al. Constrictive pericarditis in the modern era: evolving clinical spectrum and impact on outcome after pericardiectomy. Circulation. 1999;100:1380–6.CrossRefPubMedGoogle Scholar
  7. 7.
    Welch TD, Ling LH, Espinosa RE, Anavekar NS, Wiste HJ, Lahr BD, Schaff HV, Oh JK. Echocardiographic diagnosis of constrictive pericarditis: mayo clinic criteria. Circ Cardiovasc Imaging. 2014;7(3):526–34.CrossRefPubMedGoogle Scholar
  8. 8.
    Syed FF, Schaff HV, Oh JK. Constrictive pericarditis-a curable diastolic HF. Nat Rev Cardiol. 2014;11(9):530–44.CrossRefPubMedGoogle Scholar
  9. 9.
    Lancellotti P, et al. Expert consensus for multi-modality imaging evaluation of cardiovascular complications of radiotherapy in adults: a report from the European Association of Cardiovascular Imaging and the American Society of Echocardiography. J Am Soc Echocardiogr. 2013;14:721–40.Google Scholar
  10. 10.
    Little WC, Freeman GL. Pericardial disease. Circulation. 2006;113:1622–32.CrossRefPubMedGoogle Scholar
  11. 11.
    Talreja DR, et al. Constrictive pericarditis in the modern era. Novel criteria for diagnosis in the cardiac catheterization laboratory. J Am Coll Cardiol. 2008;51(3):315–9.CrossRefPubMedGoogle Scholar
  12. 12.
    Alder Y, et al. 2015 ESC guidelines on the diagnosis and management of pericardial diseases. Eur Heart J. 2015;36:2921–64.CrossRefGoogle Scholar
  13. 13.
    Paul Sorajja MD. Invasive hemodynamics of constrictive pericarditis, restrictive cardiomyopathy, and cardiac tamponade. Cardiol Clin. 2011;29:191–9.CrossRefPubMedGoogle Scholar
  14. 14.
    Syed IS, Glockner JF, Feng D, Araoz PA, Martinez MW, Edwards WD, Gertz MA, Dispenzieri A, Oh JK, Bellavia D, Tajik AJ, Grogan M. Role of cardiac magnetic resonance imaging in the detection of cardiac amyloidosis. JACC Cardiovasc Imaging. 2010;3(2):155–64.CrossRefPubMedGoogle Scholar
  15. 15.
    Argula RG, Negi SI, Banchs J, et al. Role of a 12-lead electrocardiogram in the diagnosis of cardiac tamponade as diagnosed by transthoracic echocardiography in patients with malignant pericardial effusion. Clin Cardiol. 2015;38:139–44.CrossRefPubMedGoogle Scholar
  16. 16.
    Singh S, Wann L, Klopfenstein H, et al. Usefulness of right ventricular collapse in diagnosing cardiac tamponade and comparison to pulsus paradoxus. Am J Cardiol. 1986;57:652–7.CrossRefPubMedGoogle Scholar
  17. 17.
    Armstrong WF, Schilt BF, Helper DJ, et al. Diastolic collapse of the right ventricle with cardiac tamponade: an echocardiographic study. Circulation. 1982;65:1491–6.CrossRefPubMedGoogle Scholar
  18. 18.
    Leimgruber PP, Klopfenstein HS, Wann LS, et al. The hemodynamic derangements associated with right ventricular diastolic collapse in cardiac tamponade: an experimental echocardiographic study. Circulation. 1983;68:612–20.CrossRefPubMedGoogle Scholar
  19. 19.
    Gillam LD, Guyer DE, Gibson TC, et al. Hydrodynamic compression of the right atrium: a new echocardiographic sign of cardiac tamponade. Circulation. 1983;68:294–301.CrossRefPubMedGoogle Scholar
  20. 20.
    Appleton CP, Hatle LK, Popp RL. Cardiac tamponade and pericardial effusion: respiratory variation in transvalvular flow velocities studied by Doppler echocardiography. J Am Coll Cardiol. 1988;11:1020–30.CrossRefPubMedGoogle Scholar
  21. 21.
    Hoit B, Sahn DJ, Shabetai R. Doppler-detected paradoxus of mitral and tricuspid valve flows in chronic lung disease. J Am Coll Cardiol. 1986;8:706–9.CrossRefPubMedGoogle Scholar
  22. 22.
    Rudski L, Wai W, Aifalo J, et al. Guidelines for the echocardiographic assessment of the right heart in the adult: a report from the American Society of Echocardiography endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography. J Am Soc Echocardiogr. 2010;23:685–713.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Saamir A. Hassan
    • 1
    Email author
  • Poojita Shivamurthy
    • 1
  • Syed Wamique Yusuf
    • 1
  1. 1.Department of CardiologyUniversity of Texas MD AndersonHoustonUSA

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