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Vulvar Disease pp 325-330 | Cite as

Aphthous Ulcers: Lipschütz Ulcer, Syphilis and Other STI

  • Jacob Bornstein
Chapter

Abstract

Of all causes of vulvar cancers, herpes genitalis is the most frequent infectious cause. The approach to the vulvar ulcer should determine if it is a sexually or nonsexually transmitted infection and if neoplasia is involved. Another approach to differentiate vulvar ulcers is according to their presentation, for example, the ulcer being acute, recurrent, or chronic. The differential diagnosis is made according to whether pain, dysuria, or recurrence exists. Specific etiologies of vulvar ulcer are discussed: syphilis, lymphogranuloma venereum (LGV), granuloma inguinale, chancroid, Lipschütz ulcer, and Behcet’s syndrome.

References

  1. 1.
    Tomas ME, Getman D, Donskey CJ, Hecker MT. Overdiagnosis of urinary tract infection and underdiagnosis of sexually transmitted infection in adult women presenting to an emergency department. J Clin Microbiol. 2015;53:2686.CrossRefGoogle Scholar
  2. 2.
    Morshed MG, Singh AE. Recent trends in the serologic diagnosis of syphilis. Clin Vaccine Immunol. 2015;22:137.CrossRefGoogle Scholar
  3. 3.
    O’Farrell N. Donovanosis. Sex Transm Infect. 2002;78:452.CrossRefGoogle Scholar
  4. 4.
    Workowski KA, Bolan GA, Centers for Disease Control and Prevention. Sexually transmitted diseases treatment guidelines. MMWR Recomm Rep. 2015;64:1–137.CrossRefGoogle Scholar
  5. 5.
    Mertz KJ, Weiss JB, Webb RM, et al. An investigation of genital ulcers in Jackson, Mississippi, with use of a multiplex polymerase chain reaction assay: high prevalence of chancroid and human immunodeficiency virus infection. J Infect Dis. 1998;178:1060–6.CrossRefGoogle Scholar
  6. 6.
    Sehgal VN, Pandhi D, Khurana A. Nonspecific genital ulcers. Clin Dermatol. 2014;32:259.CrossRefGoogle Scholar
  7. 7.
    Finch JJ, Wald J, Ferenczi K, et al. Disseminated Lyme disease presenting with nonsexual acute genital ulcers. JAMA Dermatol. 2014;150:1202.CrossRefGoogle Scholar
  8. 8.
    Farhi D, Wendling J, Molinari E, et al. Non-sexually related acute genital ulcers in 13 pubertal girls: a clinical and microbiological study. Arch Dermatol. 2009;145:38.CrossRefGoogle Scholar
  9. 9.
    Vieira-Baptista P, Lima-Silva J, Beires J, Martinez-de-Oliveira J. Lipschütz ulcers: should we rethink this? An analysis of 33 cases. Eur J Obstet Gynecol Reprod Biol. 2016;198:149.CrossRefGoogle Scholar
  10. 10.
    Jerdan K, Aronson I, Hernandez C, et al. Genital ulcers associated with Epstein-Barr virus. Cutis. 2013;91:273.PubMedGoogle Scholar
  11. 11.
    Sárdy M, Wollenberg A, Niedermeier A, Flaig MJ. Genital ulcers associated with Epstein-Barr virus infection (ulcus vulvae acutum). Acta Derm Venereol. 2011;91:55.CrossRefGoogle Scholar
  12. 12.
    Lehman JS, Bruce AJ, Wetter DA, et al. Reactive nonsexually related acute genital ulcers: review of cases evaluated at Mayo Clinic. J Am Acad Dermatol. 2010;63:44.CrossRefGoogle Scholar
  13. 13.
    Calamia KT, Wilson FC, Icen M, et al. Epidemiology and clinical characteristcs of Behçet’s disease in the US: a population-based study. Arthritis Rheum. 2009;61:600–4.CrossRefGoogle Scholar
  14. 14.
    International Study Group for Behçet Disease. Criteria for diagnosis of Behçet’s disease. International study Group for Behçet disease. Lancet. 1990;335:1078–80.Google Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  • Jacob Bornstein
    • 1
  1. 1.Department of Obstetrics and Gynecology Galilee Medical Center, Bar-Ilan University Faculty of MedicineNahariyaIsrael

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