Skin and soft tissue infections (SSTIs) and abscesses at the vulva, vagina, groin, breast, and postoperative wounds are vulvar manifestations of methicillin-resistant Staphylococcus aureus (MRSA) infections. Nearly two-thirds of cultures revealed MRSA. Trimethoprim-sulfamethoxazole (TMP-SMX) is largely effective against MRSA along with other common vulvar abscess microbes, such as Proteus, Escherichia coli, and group B streptococcus. Decolonization includes nasal decolonization with mupirocin and topical body decolonization with skin disinfectants. Oral antibiotics for decolonization have not been shown to be efficacious unless an active infection is present.