Vulvar Disease pp 231-232 | Cite as

Mammary-Like Gland Adenoma: Hidradenoma Papilliferum

  • Amanda Selk
  • David Nunns
  • Sandra Ronger Savle


Mammary-like gland adenoma (hidradenoma papilliferum) is a rare benign tumor arising from mammary-like anogenital glands. The etiology is unknown, but these tumors are the most common vulvar adnexal lesion. The lesions are often asymptomatic slow-growing nodules that do not require treatment but should be excised or biopsied if there are concerning features for malignancy.


  1. 1.
    El-Khoury J, Renald MH, Plantier F, Avril MF, Moyal-Barracco M. Vulvar hidradenoma papilliferum (HP) is located on the sites of mammary-like anogenital glands (MLAGs): analysis of the photographs of 52 tumors. J Am Acad Dermatol. 2016;75(2):380–4.CrossRefGoogle Scholar
  2. 2.
    Baker GM, Selim MA, Hoang MP. Vulvar adnexal lesions: a 32-year, single-institution review from Massachusetts General Hospital. Arch Pathol Lab Med. 2013;137(9):1237–46.CrossRefGoogle Scholar
  3. 3.
    Konstantinova AM, Kyrpychova L, Belousova IE, et al. Anogenital mammary-like glands: a study of their normal histology with emphasis on glandular depth, presence of columnar epithelial cells, and distribution of elastic fibers. Am J Dermatopathol. 2016;39(9):663–7.CrossRefGoogle Scholar
  4. 4.
    Konstantinova AM, Michal M, Kacerovska D, et al. Hidradenoma Papilliferum: a Clinicopathologic study of 264 tumors from 261 patients, with emphasis on mammary-type alterations. Am J Dermatopathol. 2016;38(8):598–607.CrossRefGoogle Scholar
  5. 5.
    Konstantinova AM, Stewart CJ, Kyrpychova L, Belousova IE, Michal M, Kazakov DV. An immunohistochemical study of anogenital mammary-like glands. Am J Dermatopathol. 2016;39(8):599–605.CrossRefGoogle Scholar
  6. 6.
    Kurashige Y, Kishida K, Kurashige K, Minemura T, Nagatani T. Hidradenoma papilliferum of the vulva in association with an anogenital mammary-like gland. J Dermatol. 2014;41(5):411–3.CrossRefGoogle Scholar
  7. 7.
    Duhan N, Kalra R, Singh S, Rajotia N. Hidradenoma papilliferum of the vulva: case report and review of literature. Arch Gynecol Obstet. 2011;284(4):1015–7.CrossRefGoogle Scholar
  8. 8.
    Scurry J, van der Putte SC, Pyman J, Chetty N, Szabo R. Mammary-like gland adenoma of the vulva: review of 46 cases. Pathology. 2009;41(4):372–8.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  • Amanda Selk
    • 1
  • David Nunns
    • 2
  • Sandra Ronger Savle
    • 3
  1. 1.Women’s College Hospital, Mount Sinai Hospital, University of TorontoTorontoCanada
  2. 2.Department of Gynaecological OncologyNottingham University HospitalNottinghamUK
  3. 3.Department of Dermatology and GynecologyLyon 1 University and Centre Hospitalier Lyon Sud, Pierre BéniteLyonFrance

Personalised recommendations