Applications of Glycosaminoglycans in the Medical, Veterinary, Pharmaceutical, and Cosmetic Fields



Glycosaminoglycans (GAGs) are complex polysaccharides ubiquitously present in the extracellular matrix of mammalian tissues, where they constitute the gelatinous material responsible for maintaining the cells together, in an intimate association with a variety of proteins. Although their structures are not strictly regular, they are composed of a repeating unit of a hexosamine-containing disaccharide. Most of them possess uronic acid residues, and with the exception of hyaluronic acid, they also carry sulfate groups. As a consequence of their high negative charge, they have an extraordinary capacity to absorb water. GAGs participate in many relevant biological processes by interaction with a plethora of proteins, and thus, a large number of applications in different fields have been conceived for GAGs and their derivatives.


Glycosaminoglycan Sulfation Alzheimer’s disease Tissue engineering Cancer treatment Osteoarthritis Skin hydration Cross-linked glycosaminoglycans 


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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • José Kovensky
    • 1
  • Eric Grand
    • 1
  • María Laura Uhrig
    • 2
    • 3
  1. 1.Laboratoire de Glycochimie, des Antimicrobiens et des Agroressources (LG2A) CNRS UMR 7378, Institut de Chimie de Picardie CNRS FR 3085Université de Picardie Jules VerneAmiens CedexFrance
  2. 2.Facultad de Ciencias Exactas y Naturales, Departamento de Química OrgánicaUniversidad de Buenos Aires, Pabellón 2, Ciudad UniversitariaBuenos AiresArgentina
  3. 3.Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)-UBA, Centro de Investigación en Hidratos de Carbono (CIHIDECAR)Buenos AiresArgentina

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