Biopsy and Oral Squamous Cell Carcinoma Histopathology

  • Dimitrios A. AndreadisEmail author
  • Achilleia-Maria Pavlou
  • Prashanth Panta


Oral cancer is a fairly common disease, which is unfortunately often diagnosed when it has reached an advanced stage. Early diagnosis is crucial for better prognosis and survival. In addition to better survival figures, early diagnosis also provides sufferers with a better quality of life. Biopsy is widely accepted as the “gold standard” diagnostic method for lesions raising suspicion of malignancy. There are several types of biopsy including incisional biopsy, excisional biopsy, fine needle aspiration, punch biopsy, and brush biopsy, each with specific indications, special methodology, advantages, and disadvantages. The use of biopsy and analyzing the results under the microscope is the gold standard for confirming a diagnosis of oral squamous cell carcinoma diagnosis. Biopsy is indicated in mucosal lesions (especially ulcers), and it is of critical importance to reveal oral dysplasia, to confirm the clinical suspicion for an early invasive cancer, or to establish the grade of differentiation of oral squamous cell carcinoma for accurate therapeutic procedure and in the determination of prognosis.


Incisional biopsy Excisional biopsy Fine needle aspiration Punch biopsy Brush Biopsy Microscopy Dysplasia Oral cancer 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  • Dimitrios A. Andreadis
    • 1
    Email author
  • Achilleia-Maria Pavlou
    • 1
  • Prashanth Panta
    • 2
  1. 1.Department of Oral Medicine/PathologySchool of Dentistry, Aristotle University of ThessalonikiThessalonikiGreece
  2. 2.Department of Oral Medicine and RadiologyMNR Dental College and HospitalSangareddyIndia

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