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Epidemiology of Oral Cancer

  • José Manuel García-Martín
  • Pablo Varela-Centelles
  • Manuel González
  • Juan M. Seoane-Romero
  • Juan Seoane
  • María José García-PolaEmail author
Chapter

Abstract

Oral cancer represents a health problem worldwide due to its morbidity and mortality. The prevalence of oral cancer presents some variations around the world. These rates vary by as much as 20-fold among different countries, age groups, gender, races, and ethnic groups. Globally, the emergence of oral cancer is higher in male than female, and the risk increases with age. In 2013, oral cancer incidence ranked eleventh among all sites of cancer. The Indian subcontinent accounts for one-third of the oral cancer burden in the world. Oral cancer is the most common cancer among men in India and the second cancer among Pakistani women. The lowest rates are found in Western Africa and Eastern Asia. North African countries also present low incidences.

Surveillance of oral cavity and pharyngeal cancer at 5 years after diagnosis has estimated survival around 50% and for salivary gland carcinoma up to more than 85%.

Worldwide, the mortality rate of oral cancer was higher in male than in female. Death from oral cancer ranks fifteenth place for men and seventeenth for women in the US population. In Europe, it ranked the seventh and tenth, respectively.

The highest risk for lip cancer is experienced in Spain and in Australia and North America for salivary gland tumors. Globally, salivary gland malignant tumor is an infrequent carcinoma, and it is not considered among the tenth major cancers. Although in some developed countries oral cancer has decreased (the USA or Canada), in another, e.g., certain European countries, it has increased. Many of these differences are undoubtedly caused by differing population habits, life expectancies, preventive education, and the quality of medical records in various countries. These data can be helpful in identifying potential causative factors.

Keywords

Oral cancer Epidemiology Incidence Survival Mortality 

References

  1. 1.
    Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136:E359–86.Google Scholar
  2. 2.
    Leoncini E, Vukovic V, Cadoni G, Pastorino R, Arzani D, Bosetti C, et al. Clinical features and prognostic factors in patients with head and neck cancer: results from a multicentric study. Cancer Epidemiol. 2015;39:367–74.Google Scholar
  3. 3.
    Singh MP, Misra S, Rathanaswamy SP, Gupta S, Tewari BN, Bhatt ML, et al. Clinical profile and epidemiological factors of oral cancer patients from North India. Natl J Maxillofac Surg. 2015;6:21–4.Google Scholar
  4. 4.
    Warnakulasuriya S. Global epidemiology of oral and oropharyngeal cancer. Oral Oncol. 2009;45:309–16.Google Scholar
  5. 5.
    Forman D, Bray F, Brewster DH, Gombe Mbalawa C, Kohler B, Piñeros M, et al., editors Cancer Incidence in Five Continents, Vol. X. IARC Scientific Publication N°. 164. Lyon: International Agency for Research on Cancer. 2014.Google Scholar
  6. 6.
    Kohler BA, Sherman RL, Howlader N, Jemal A, Ryerson AB, Henry KA, et al. Annual Report to the Nation on the Status of Cancer, 1975–2011, Featuring Incidence of Breast Cancer Subtypes by Race/Ethnicity, Poverty, and State. J Natl Cancer Inst. 2015;107:djv048.Google Scholar
  7. 7.
    Global Burden of Disease Cancer Collaboration, Fitzmaurice C, Dicker D, Pain A, Hamavid H, Moradi-Lakeh M, MacIntyre MF et al. The Global Burden of Cancer 2013. JAMA Oncol. 2015;1:505–27.Google Scholar
  8. 8.
    Edwards BK, Brown ML, Wingo PA, Howe HL, Ward E, Ries LA, et al. Annual report to the nation on the status of cancer, 1975-2002, featuring population-based trends in cancer treatment. J Natl Cancer Inst. 2005;97:1407–27.Google Scholar
  9. 9.
    Jemal A, Clegg LX, Ward E, Ries LA, Wu X, Jamison PM, et al. Annual report to the nation on the status of cancer, 1975-2001, with a special feature regarding survival. Cancer. 2004;101:3–27.Google Scholar
  10. 10.
    Erickson B, Biron VL, Zhang H, Seikaly H, Côté DW. Survival outcomes of first nations patients with oral cavity squamous cell carcinoma (Poliquin 2014). J Otolaryngol Head Neck Surg. 2015;44:4.Google Scholar
  11. 11.
    Politis M, Higuera G, Chang LR, Gomez B, Bares J, Motta J. Trend analysis of Cancer mortality and incidence in Panama, using joinpoint regression analysis. Medicine (Baltimore). 2015;94:e970.Google Scholar
  12. 12.
    Khan Z, Muller S, Ahmed S, Tonnies J, Nadir F, Samkange-Zeeb F. Quantitative review of oral Cancer research output from Pakistan. Asian Pac J Cancer Prev. 2015;16:4733–9.Google Scholar
  13. 13.
    Chi AC, Day TA, Neville BW. Oral cavity and oropharyngeal squamous cell carcinoma—an update. CA Cancer J Clin. 2015;65:401–21.  https://doi.org/10.3322/caac.21293.
  14. 14.
    Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65:87–108.  https://doi.org/10.3322/caac.21262.
  15. 15.
    BenNasir E, El Mistiri M, McGowan R, Katz RV. Oral cancer in Libya and development of regional oral cancer registries: a review. Saudi Dent J. 2015;27:171–9.Google Scholar
  16. 16.
    Hayat MJ, Howlader N, Reichman ME, Edwards BK. Cancer statistics, trends, and multiple primary cancer analyses from the surveillance, epidemiology, and end results (SEER) program. Oncologist. 2007;12:20–37.Google Scholar
  17. 17.
    Neville B, Damm DD, Allen C, Bouquot J. Oral & Maxillofacial Apthology. WB. Saunders Company; 2002.Google Scholar
  18. 18.
    Oliveira ML, Wagner VP, Sant'ana Filho M, Carrard VC, Hugo FN, Martins MD. A 10-year analysis of the oral squamous cell carcinoma profile in patients from public health centers in Uruguay. Braz Oral Res 2015;29. pii: S1806–83242015000100270.Google Scholar
  19. 19.
    Frydrych AM, Slack-Smith LM, Parsons R, Threlfall T. Oral cavity squamous cell carcinoma—characteristics and survival in aboriginal and non-aboriginal western australians. Open Dent J 2014; 8: 168–74.Google Scholar
  20. 20.
    Mishra GA, Dhivar HD, Gupta SD, Kulkarni SV, Shastri SS. A population-based screening program for early detection of common cancers among women in India—methodology and interim results. Indian J Cancer. 2015;52:139–45.Google Scholar
  21. 21.
    Abel GA, Shelton J, Johnson S, Elliss-Brookes L, Lyratzopoulos G. Cancer-specific variation in emergency presentation by sex, age and deprivation across 27 common and rarer cancers. Br J Cancer. 2015;112:S129–36.Google Scholar
  22. 22.
    Bray F, Ren JS, Masuyer E, Ferlay J. Global estimates of cancer prevalence for 27 sites in the adult population in 2008. Int J Cancer. 2013;132:1133–45.Google Scholar
  23. 23.
    Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010;127:2893–917.Google Scholar
  24. 24.
    Krishna Rao S, Mejia GC, Roberts-Thomson K, Logan RM. Kamath estimating the effect of childhood socioeconomic disadvantage on oral cancer in India using marginal structural models. Epidemiology. 2015;26:509–17.Google Scholar
  25. 25.
    Maleki D, Ghojazadeh M, Mahmoudi SS, Mahmoudi SM, Pournaghi-Azar F, Torab A, et al. Epidemiology of oral Cancer in Iran: a systematic review. Asian Pac J Cancer Prev. 2015;16:5427–32.Google Scholar
  26. 26.
    Zhang S-K, Zheng R, Chen Q, Zhang S, Sun X, Chen W. Oral cancer incidence and mortality in China, 2011. Chin J Cancer Res. 2015;27:44–51.Google Scholar
  27. 27.
    Simard EP, Torre LA, Jemal A. International trends in head and neck cancer incidence rates: differences by country, sex and anatomic site. Oral Oncol 2014;50: 387–403.Google Scholar
  28. 28.
    Hippisley-Cox J, Coupland C. Development and validation of risk prediction algorithms to estimate future risk of common cancers in men and women: prospective cohort study. BMJ Open. 2015 Mar 17;5:e007825.Google Scholar
  29. 29.
    Shoaee S, Ghasemian A, Mehrabani K, Naderimagham S, Delavari F, Sheidaei A, et al. Burden of Oral Diseases in Iran, 1990–2010: Findings from the Global Burden of Disease Study 2010. Arch Iran Med 2015;18:486–492.Google Scholar
  30. 30.
    Russell JL, Chen NW, Ortiz SJ, Schrank TP, Kuo YF, Resto VA. Racial and ethnic disparities in salivary gland Cancer survival. JAMA Otolaryngol Head Neck Surg. 2014;140(6):504–12.Google Scholar
  31. 31.
    Kao SY, Lim E. An overview of detection and screening of oral cancer in Taiwan. Chin J Dent Res. 2015;18:7–12.Google Scholar
  32. 32.
    Goodwin WJ, Thomas GR, Parker DF, Joseph D, Levis S, Franzmann E, et al. Unequal burden of head and neck cancer in the United States. Head Neck. 2008;30:358–71.Google Scholar
  33. 33.
    Howe HL, Wu X, Ries LA, Cokkinides V, Ahmed F, Jemal A, et al. Annual report to the nation on the status of cancer, 1975-2003, featuring cancer among U.S. Hispanic/Latino populations. Cancer. 2006;107:1711–42.Google Scholar
  34. 34.
    Espey DK, Wu XC, Swan J, Wiggins C, Jim MA, Ward E, et al. Annual report to the nation on the status of cancer, 1975-2004, featuring cancer in American Indians and Alaska natives. Cancer. 2007;110:2119–52.Google Scholar
  35. 35.
    Pinheiro PS, Sherman RL, Trapido EJ, Fleming LE, Huang Y, Gomez-Marin O, et al. Cancer incidence in first generation U.S. Hispanics: Cubans, Mexicans, Puerto Ricans, and new Latinos. Cancer Epidemiol Biomark Prev. 2009;18:2162–9.Google Scholar
  36. 36.
    Moore SP, Forman D, Piñeros M, Fernández SM, de Oliveira Santos M, Bray F. Cancer in indigenous people in Latin America and the Caribbean: a review. Cancer Med. 2014;3:70–80.Google Scholar
  37. 37.
    Walker BB, Schuurman N, Auluck A, Lear SA, Rosin M. Suburbanisation of oral cavity cancers: evidence from a geographically-explicit observational study of incidence trends in British Columbia, Canada, 1981–2010. BMC Public Health. 2015;15:758.Google Scholar
  38. 38.
    Marx R, Steern D. Oral and maxillofacial pathology. A rationale for diagnosis and treatment Quintessence Publishing Co, Inc Chicago. 2012.Google Scholar
  39. 39.
    Domínguez-Gordillo A, Esparza-Gómez G, García-Jiménez B, Cerero-Lapiedra R, Casado-Gómez I, Romero-Lastra P, et al. The pattern of lip cancer occurrence over the 1990-2011 period in public hospitals in Madrid, Spain. J Oral Pathol Med. 2015;8:202.Google Scholar
  40. 40.
    Khammissa RA, Meer S, Lemmer J, Feller L. Oral squamous cell carcinoma in a South African sample: race/ethnicity, age, gender, and degree of histopathological differentiation. J Cancer Res Ther. 2014;10:908–14.Google Scholar
  41. 41.
    Osazuwa-Peters N, Massa ST, Christopher KM, Walker RJ, Varvares MA. Race and sex disparities in long-term survival of oral and oropharyngeal cancer in the United States. J Cancer Res Clin Oncol. 2016;142:521–8.Google Scholar
  42. 42.
    Badwe RA, Dikshit R, Laversanne M, Bray F. Cancer incidence trends in India. Jpn J Clin Oncol. 2014;44(5):401–7.Google Scholar
  43. 43.
    Barnes L, Eveson J, Reichart P, Sidransky D, editors. World Health Organization classification of tomours. Pathology and genetics of tumours of the head and neck. Lyon: IARC. Press; 2005. WHO.Google Scholar
  44. 44.
    Molina MA, Cheung MC, Perez EA, Byrne MM, Franceschi D, Moffat FL, et al. African American and poor patients have a dramatically worse prognosis for head and neck cancer: an examination of 20,915 patients. Cancer 2008;113:2797–806.Google Scholar
  45. 45.
    Shigeishi H, Ohta K, Okui G, Seino S, Hashikata M, Yamamoto K, et al. Clinicopathological analysis of salivary gland carcinomas and literature review. Mol Clin Oncol. 2015;3:202–6.Google Scholar
  46. 46.
    Innos K, Padrik P, Valvere V, Aareleid T. Sex differences in cancer survival in Estonia: a population-based study. BMC Cancer 2015;15:72.Google Scholar
  47. 47.
    Chu KP, Habbous S, Kuang Q, Boyd K, Mirshams M, Liu FF, et al. Socioeconomic status, human papillomavirus, and overall survival in head and neck squamous cell carcinomas in Toronto, Canada. Cancer Epidemiol. 2016;40:102–12.Google Scholar
  48. 48.
    Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, Rosso S, Coebergh JW, Comber H, et al. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. Eur J Cancer. 2013;49:1374–403.Google Scholar
  49. 49.
    van Monsjou HS, Schaapveld M, Hamming-Vrieze O, de Boer JP, van den Brekel MW, Balm AJ. Cause-specific excess mortality in patients treated for cancer of the oral cavity and oropharynx: a population-based study. Oral Oncol. 2016;52:37–44.Google Scholar
  50. 50.
    Olarte LS, Megwalu UC. The impact of demographic and socioeconomic factors on major salivary gland Cancer survival. Otolaryngol Head Neck Surg. 2014;150:991–8.Google Scholar
  51. 51.
    Bjørndal K, Larsen SR, Therkildsen MH, Kristensen CA, Charabi B, Andersen E, et al. Danish head and neck Cancer group (DAHANCA) and academy of geriatric Cancer research (AgeCare). Does age affect prognosis in salivary gland carcinoma patients? A national Danish study. Acta Oncol. 2016;55:19–22.Google Scholar
  52. 52.
    Baddour HM Jr, Fedewa SA, Chen AY. Five- and 10-year cause-specific survival rates in carcinoma of the minor salivary gland. JAMA Otolaryngol Head Neck Surg. 2016;142:67–73.Google Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  • José Manuel García-Martín
    • 1
  • Pablo Varela-Centelles
    • 2
  • Manuel González
    • 1
  • Juan M. Seoane-Romero
    • 3
  • Juan Seoane
    • 3
  • María José García-Pola
    • 1
  1. 1.Department of Surgery and Medical-Surgical SpecialtiesSchool of Medicine and Health Sciences, University of OviedoOviedoSpain
  2. 2.HULA, EOXI Lugo, Cervo, e Monforte de Lemos, Galician Health ServiceLugoSpain
  3. 3.Stomatology Department, School of Medicine and DentistryUniversity of Santiago de CompostelaSantiago de CompostelaSpain

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