Optical Coherence Tomography: Emerging In Vivo Optical Biopsy Technique for Oral Cancers

  • Prashanth PantaEmail author
  • Chih-Wei Lu
  • Piyush Kumar
  • Tuan-Shu Ho
  • Sheng-Lung Huang
  • Pawan Kumar
  • C. Murali Krishna
  • K. Divakar Rao
  • Renu John


Oral cancers are a major health burden, and patients suffer from low survival rate owing to their late detection. Optical techniques are rapid, objective, and noninvasive methods with the potential to serve as adjunct screening/diagnostic tools, especially for cancers. This chapter highlights the advancements in oral cancer exploration using optical coherence tomography (OCT) with a discussion on basic principles of OCT, followed by a detailed description of oral cancer studies, subgrouped into animal studies, and ex vivo and in vivo human studies. We have included full-field OCT system-derived in vivo oral mucosa images in a healthy volunteer at different subsites showing standard microanatomy at various depths and also narrated some strategies to improve OCT results by multimodal approaches as well as through contrast enhancement for improved visualization.


Optical coherence tomography Oral cancer Optical biopsy Noninvasive Imaging 



We thank Yunglin David Ma and Allen Lin from Apollo Medical Optics, Ltd. for their cooperation.


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  • Prashanth Panta
    • 1
    Email author
  • Chih-Wei Lu
    • 2
  • Piyush Kumar
    • 3
  • Tuan-Shu Ho
    • 2
    • 4
  • Sheng-Lung Huang
    • 2
    • 4
  • Pawan Kumar
    • 5
  • C. Murali Krishna
    • 6
    • 7
  • K. Divakar Rao
    • 8
  • Renu John
    • 5
  1. 1.Department of Oral Medicine and RadiologyMNR Dental College and HospitalSangareddyIndia
  2. 2.Apollo Medical Optics, Ltd. (AMO)TaipeiTaiwan
  3. 3.Amity Institute of Biotechnology, Amity University MumbaiNavi MumbaiIndia
  4. 4.Graduate Institute of Photonics and Optoelectronics, National Taiwan UniversityTaipeiTaiwan
  5. 5.Department of Biomedical EngineeringIndian Institute of TechnologyHyderabadIndia
  6. 6.Chilakapati LaboratoryAdvanced Centre for Treatment Research and Education in Cancer (ACTREC), Tata Memorial Centre (TMC)MumbaiIndia
  7. 7.Homi Bhabha National InstituteAnushakti Nagar, MumbaiIndia
  8. 8.Photonics and Nanotechnology SectionBhabha Atomic Research Centre FacilityVisakhapatnamIndia

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