Tree-Based Ensemble Learning Techniques in the Analysis of Parkinsonian Syndromes

  • J. M. GórrizEmail author
  • J. Ramírez
  • M. Moreno-Caballero
  • F. J. Martinez-Murcia
  • A. Ortiz
  • I. A. Illán
  • F. Segovia
  • D. Salas-González
  • M. Gomez-Rio
Conference paper
Part of the Communications in Computer and Information Science book series (CCIS, volume 723)


\(^{123}\)I-ioflupane single photon emission computed tomography (SPECT) is a standard and well-known imaging modality in the medical practice for the diagnosis of Parkinson’s disease (PD). That said, atypical parkinsonian syndrome (APS), a symptom-related disease to PD, detection is yet considered inconsistent at least based on visual inspection on region of interests (ROIs). Although some machine learning approaches have been proposed in this regard, in this paper we take up this matter again by applying advanced image processing techniques based on ensemble learning in order to discriminate PD from the various APS, included in the group denominated as P plus. This study enrolled 168 subjects including followed-up patients with degenerative parkinsonism and normal controls undergoing \(^{123}\)I-ioflupane SPECT at the “Virgen de las Nieves” Hospital, Spain in the last years: 45 Normal, 75 PD, 31 APs (including multiple system atrophy (MSA), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) patients) and 17 controls. Several advanced ensemble techniques and feature extraction methods were applied voxel-wise to the analysis of the SPECT images using robust classifiers based on decision trees. The system is trained by means of boosting and bagging algorithms and their performance control is specified in terms of the classification error and the received operating characteristics curve (ROC) using 10-fold cross validation. By the use of these statistical validation methods it was possible to confirm that this modality may be useful for discriminating the abnormal patterns under study.


Atypical parkinsonism Single photon emission computed tomography (SPECT) Ensemble pattern recognition Boosting Bagging Decision tress 



This work was partly supported by the MINECO/FEDER under the TEC2015-64718-R project and the Consejería de Innovación, Ciencia y Empresa (Junta de Andalucía, Spain) under the Excellence Project P11-TIC-7103.


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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • J. M. Górriz
    • 1
    Email author
  • J. Ramírez
    • 1
  • M. Moreno-Caballero
    • 2
  • F. J. Martinez-Murcia
    • 1
  • A. Ortiz
    • 4
  • I. A. Illán
    • 3
  • F. Segovia
    • 1
  • D. Salas-González
    • 1
  • M. Gomez-Rio
    • 2
  1. 1.Department of Signal Theory and CommunicationsUniversity of GranadaGranadaSpain
  2. 2.Hospital Virgen de Las NievesGranadaSpain
  3. 3.Department of Scientific ComputingThe Florida State UniversityTallahasseeUSA
  4. 4.Department Communication EngineeringUniversity of MalagaMalagaSpain

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