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Introduction to Benign and Malignant Disorders of the Nipple-Areolar Complex

  • Melvin A. Shiffman
Chapter

Abstract

Benign and malignant disorders can affect the nipple-areolar complex. These can include skin changes in and around the nipple and areola, infection, benign tumors, and malignant tumors. The author covers the subjects of abscess, adenoma, basal cell carcinoma, eczema, epithelioma, fibroma, fibrous histiocytoma, hyperkeratosis, cysts, ichthyosis circumscripta, leiomyoma, leiomyosarcoma, melanoma, melanosis, molluscum contagiosum, nevus, nodular mucinosis, neuroma and neurofibromatosis, nevus, nodular mucinosis, Paget’s disease, papilloma, sarcoma, seborrheic keratosis, and squamous cell carcinoma.

References

  1. 1.
    Bengualid V, Singh V, Singh H, Berger J. Mycobacterium fortuitum and anaerobic breast abscess following nipple piercing: case presentation and review of the literature. J Adolesc Health. 2008;42(5):530–2.PubMedCrossRefGoogle Scholar
  2. 2.
    Leibman AJ, Misra M, Castaldi M. Breast abscess after nipple piercing: sonographic findings with clinical correlation. J Ultrasound Med. 2011;30(9):1303–8.PubMedCrossRefGoogle Scholar
  3. 3.
    Abbass K, Adnan MK, Markert RJ, Emig M, Khan NA. Mycobacterium fortuitum breast abscess after nipple piercing. Can Fam Physician. 2014;60(1):51–2.PubMedPubMedCentralGoogle Scholar
  4. 4.
    Chalot. Gaz. Hebd. d. sc. Méd de Montpellier. 1881;III:253. In: Deaver JB, McFarland J, Herman L, editors. The breast: its anomalies, its diseases, and their treatment. Philadelphia: P. Blakiston’s Son & Co.; 1917. p. 671–702.Google Scholar
  5. 5.
    Winckle. Lehrbuch der Frauenkrankheiten 1886:741. In: Deaver JB, McFarland J, Herman L, editors. The breast: its anomalies, its diseases, and their treatment. Philadelphia: P. Blakiston’s Son & Co.; 1917. p. 671–702.Google Scholar
  6. 6.
    Miyahara M, Saito T, Kaketani K, Suzuki K, Kuwahara A, Shimoda K, Kobayashi M. Adenoma of the nipple. Surg Today. 1992;22(4):368–70.PubMedCrossRefGoogle Scholar
  7. 7.
    Tsushimi T, Enoki T, Takemoto Y, Harada E, Hayashi M, Furuya T, Hamano K. Adenoma of the nipple, focusing on the contrast-enhanced magnetic resonance imaging findings: report of a case. Surg Today. 2011;41(8):1138–41.PubMedCrossRefGoogle Scholar
  8. 8.
    Gross SW. On the diagnosis of tumours of the mamma. In: Braithwaite W, Braithwaite J, Trevelyen EF, editors. The retrospect of practical medicine. New York: W.A. Townsend; 1881. p. 198–200.Google Scholar
  9. 9.
    Galloway JR, Woolner LB, Clagget OT. Adenoid cystic carcinoma. Surg Gynecol Obstet. 1966;122:1289–94.PubMedPubMedCentralGoogle Scholar
  10. 10.
    Patterson JW, Wick MR. Nonmelanotic tumors of the skin. AFIP atlas of tumor pathology, fourth series, Fascicle 4. Washington, DC: Armed Forces Institute of Pathology; 2006. pp. 158–61.Google Scholar
  11. 11.
    Roy S. Pathology of nipple adenoma (erosive adenomatosis or florid papillomatosis). http://www.histopathology-india.net/niad.html
  12. 12.
    Sarma DP, Stevens T. Infiltrating syringomatous eccrine adenoma of the nipple: a case report. Cases J. 2009;2:9118.PubMedPubMedCentralCrossRefGoogle Scholar
  13. 13.
    Rosen PP. Syringomatous adenoma of the nipple. Am J Surg Pathol. 1983;7(8):739–45.PubMedCrossRefGoogle Scholar
  14. 14.
    Hwang TS, Ham EK, Kim JP. Syringomatous adenoma of nipple—a case report. J Korean Med Sci. 1987;2(4):263–5.PubMedPubMedCentralCrossRefGoogle Scholar
  15. 15.
    Jones MW, Norris HJ, Snyder RC. Infiltrating syringomatous adenoma of the nipple: a clinical and pathological study of 11 cases. Am J Surg Pathol. 1989;13(3):197–201.PubMedCrossRefGoogle Scholar
  16. 16.
    Suster S, Moran CA, Hurt MA. Syringomatous squamous tumors of the breast. Cancer. 1991;67(9):2350–5.PubMedCrossRefGoogle Scholar
  17. 17.
    Slaughter MS, Pomerantz RA, Murad T, Hines JR. Infiltrating syringomatous adenoma of the nipple. Surgery. 1992;111(6):711–3.PubMedPubMedCentralGoogle Scholar
  18. 18.
    Coulthard A, Liston J, Young JR. Case report: infiltrating syringomatous adenoma of the breast appearances on mammography and ultrasonography. Clin Radiol. 1993;47:6244.Google Scholar
  19. 19.
    Toyoshima O, Kanou M, Kintaka N, Miyashita M, Shigematsu S, Sano J. Syringomatous adenoma of the nipple: report of a case. Surg Today. 1998;28(11):1196–9.PubMedCrossRefGoogle Scholar
  20. 20.
    Wadhwa N, Mishra K, Agarwal S. Syringomatous adenoma of the nipple: a case report. Pathology. 2003;35(3):271–2.PubMedCrossRefGoogle Scholar
  21. 21.
    Chang CK, Jacobs IA, Calilao G, Salti GI. Metastatic infiltrating syringomatous adenoma of the breast. Arch Pathol Lab Med. 2003;127:e155–6.PubMedPubMedCentralGoogle Scholar
  22. 22.
    Healy CE, Dijkstra B, Walsh M, Hill AD, Murphy J. Nipple adenoma: a differential diagnosis for Paget’s disease. Breast J. 2003;9(4):325–6.PubMedCrossRefGoogle Scholar
  23. 23.
    Ku J, Bennett RD, Chong KD, Bennett IC. Syringomatous adenoma of the nipple. Breast. 2004;13(5):412–5.PubMedCrossRefGoogle Scholar
  24. 24.
    Kubo M, Tsuji H, Kunitomo T, Taguchi K. Syringomatous adenoma of the nipple: a case report. Breast Cancer. 2004;11(2):214–6.PubMedCrossRefGoogle Scholar
  25. 25.
    Carter E, Dyess DL. Infiltrating syringomatous adenoma of the nipple: a case report and 20-year retrospective review. Breast J. 2004;10(5):443–7.PubMedCrossRefGoogle Scholar
  26. 26.
    Kijima Y, Matsukita S, Yoshinaka H, Owaki T, Aikou T. Adenoma of the nipple: report of a case. Breast Cancer. 2006;13(1):95–9.PubMedCrossRefGoogle Scholar
  27. 27.
    Kono S, Kurosumi M, Simooka H, Kawanowa K, Takei H, Suemasu K. Nipple adenoma found in a mastectomy specimen: report of a case with special regard to the proliferation pattern. Breast Cancer. 2007;14(2):234–8.PubMedCrossRefGoogle Scholar
  28. 28.
    Oliva VL, Little JV, Carlson GW. Syringomatous adenoma of the nipple—treatment by central mound resection and oncoplastic reconstruction. Breast J. 2008;14(1):102–5.PubMedCrossRefGoogle Scholar
  29. 29.
    Oo KZ, Xiao PQ. Infiltrating syringomatous adenoma of the nipple clinical presentation and literature review. Arch Pathol Lab Med. 2009;133:1487–9.PubMedPubMedCentralGoogle Scholar
  30. 30.
    Healy CE, Dijkstra B, Walsh M, Hill AD, Murphy J. Nipple adenoma: a differential diagnosis for Paget’s disease. Breast J. 2003;9(4):325–6.PubMedCrossRefGoogle Scholar
  31. 31.
    Kijima Y, Matsukita S, Yoshinaka H, Owaki T, Aikou T. Adenoma of the nipple: report of a case. Breast Cancer. 2006;13(1):95–9.PubMedCrossRefGoogle Scholar
  32. 32.
    Kono S, Kurosumi M, Simooka H, Kawanowa K, Takei H, Suemasu K. Nipple adenoma found in a mastectomy specimen: report of a case with special regard to the proliferation pattern. Breast Cancer. 2007;14(2):234–8.PubMedCrossRefGoogle Scholar
  33. 33.
    Clune JE, Kozakewich HP, Van Beek CA, Labow BI, Greene AK. Nipple adenoma in infancy. J Pediatr Surg. 2009;44(11):2219–22.PubMedCrossRefGoogle Scholar
  34. 34.
    Kazakov DV, Kacerovska D, Michal M. Lactation adenoma in a supernumerary nipple. J Cutan Pathol. 2011;38(6):532–3.PubMedCrossRefGoogle Scholar
  35. 35.
    Tao W, Kai F, Yue HL. Nipple adenoma in an adolescent. Pediatr Dermatol. 2010;27(4):399–401.PubMedCrossRefGoogle Scholar
  36. 36.
    Rao P, Shousha S. Male nipple adenoma with DCIS followed 9 years later by invasive carcinoma. Breast J. 2010;16(3):317–8.PubMedCrossRefGoogle Scholar
  37. 37.
    Kazakov DV, Kacerovska D, Michal M. Lactation adenoma in a supernumerary nipple. J Cutan Pathol. 2011;38(6):532–3.PubMedCrossRefGoogle Scholar
  38. 38.
    Shioi Y, Nakamura S, Kawamura S, Kasami M. Nipple adenoma arising from axillary accessory breast: a case report. Diagn Pathol. 2012;7:162.PubMedPubMedCentralCrossRefGoogle Scholar
  39. 39.
    Fujii T, Yajima R, Morita H, Yamaguchi S, Tsutsumi S, Asao T, Kuwano H. Adenoma of the nipple projecting out of the nipple: curative resection without excision of the nipple. World J Surg Oncol. 2014;12:91.PubMedPubMedCentralCrossRefGoogle Scholar
  40. 40.
    Di Bonito M, Cantile M, Collina F, D’Aiuto M, Liguori G, De Cecio R, Botti G. Adenoma of the nipple: a clinicopathological report of 13 cases. Oncol Lett. 2014;7(6):1839–42.CrossRefGoogle Scholar
  41. 41.
    Brownstein MH, Phelps RG, Magnin PH. Papillary adenoma of the nipple: analysis of fifteen new cases. J Am Acad Dermatol. 1985;12(4):707–15.PubMedCrossRefGoogle Scholar
  42. 42.
    Perzin KH, Lattes R. 1972. Papillary adenoma of the nipple (florid papillomatosis, adenoma, adenomatosis). A clinicopathologic study. Cancer. 29 996–1009. https://www.researchgate.net/publication/227771224_Papillary_adenoma_of_the_nipple_florid_papillomatosis_adenoma_adenomatosis_A_clinicopathologic_study. Accessed 31 Mar 2016.PubMedCrossRefGoogle Scholar
  43. 43.
    Jones DB. Florid papillomatosis of the nipple ducts. Cancer. 1955;8(2):315–9.PubMedCrossRefGoogle Scholar
  44. 44.
    Doctor VM, Sirsat MV. Florid papillomatosis (adenoma) and other benign tumours of the nipple and areola. Br J Cancer. 1971;25(1):1–9.PubMedPubMedCentralCrossRefGoogle Scholar
  45. 45.
    Montemarano AD, Sau P, James WD. Superficial papillary adenomatosis of the nipple: a case report and review of the literature. J Am Acad Dermatol. 1995;33(5 Pt 2):871–5.PubMedCrossRefGoogle Scholar
  46. 46.
    Perzin KH, Lattes R. Papillary adenoma of the nipple (florid papillomatosis, adenoma, adenomatosis). A clinicopathologic study. Cancer. 1972;29(4):996–1009.PubMedCrossRefGoogle Scholar
  47. 47.
    Tuveri M, Cald PG, Mocci C, Nicolosi A. Florid papillomatosis of the male nipple. Am J Surg. 2010;3:e39–40.CrossRefGoogle Scholar
  48. 48.
    Perzin KH, Lattes R. Papillary adenoma of the nipple (florid papillomatosis, adenoma, adenomatosis). A clinicopathologic study. Cancer. https://www.researchgate.net/publication/227771224_Papillary_adenoma_of_the_nipple_florid_papillomatosis_adenoma_adenomatosis_A_clinicopathologic_study. Accessed 31 Mar 2016.
  49. 49.
    Gros CM, Le Gal Y, Bader P. Erosive adenomatosis of the nipple. Presse Med. 1959;67(15):615–6.PubMedPubMedCentralGoogle Scholar
  50. 50.
    Le Gal Y, Gros CM, Bader P. Erosive adenomatosis of the nipple. Ann Anat Pathol (Paris). 1959;4(2):292–304.Google Scholar
  51. 51.
    Peloux Y, Franco R. Erosive adenomatosis of the nipple. Apropos of a case observed in New Caledonia. Med Trop (Mars). 1965;25:71–5.Google Scholar
  52. 52.
    Pratt-Thomas HR. Erosive adenomatosis of the nipple. J S C Med Assoc. 1968;64(2):37–40.PubMedPubMedCentralGoogle Scholar
  53. 53.
    Smith EJ, Kron SD, Gross PR. Erosive adenomatosis of the nipple. Arch Dermatol. 1970;102(3):330–2.PubMedCrossRefGoogle Scholar
  54. 54.
    Smith NP, Jones EW. Erosive adenomatosis of the nipple. Clin Exp Dermatol. 1977;2(1):79–84.PubMedCrossRefGoogle Scholar
  55. 55.
    Civatte J, Restout S, Delomenie DC. Erosive adenomatosis of a supernumerary nipple. Ann Dermatol Venereol. 1977;104(11):777–9.PubMedPubMedCentralGoogle Scholar
  56. 56.
    Palermo A, Urso C. Adenoma (erosive adenomatosis) of the nipple. G Ital Dermatol Venereol. 1985;120(2):145–7.PubMedPubMedCentralGoogle Scholar
  57. 57.
    Higginbotham LH, Mikhail GR. Erosive adenomatosis of the nipple. J Dermatol Surg Oncol. 1986;12(5):514–6.PubMedCrossRefGoogle Scholar
  58. 58.
    Piérard G. Paget’s disease or erosive adenomatosis of the nipple? Dermatologica. 1990;180(1):55.PubMedCrossRefGoogle Scholar
  59. 59.
    Moulin G, Darbon P, Balme B, Frappart L. Erosive adenomatosis of the nipple. Report of 10 cases with immunohistochemistry. Ann Dermatol Venereol. 1990;117(8):537–45.PubMedPubMedCentralGoogle Scholar
  60. 60.
    Bourlond J, Bourlond-Reinert L. Erosive adenomatosis of the nipple. Dermatology. 1992;185(4):319–24.PubMedCrossRefGoogle Scholar
  61. 61.
    Diaz NM, Palmer JO, Wick MR. Erosive adenomatosis of the nipple: histology, immunohistology, and differential diagnosis. Mod Pathol. 1992;5(2):179–84.PubMedPubMedCentralGoogle Scholar
  62. 62.
    Ward KA, Burton JL. Dermatologic diseases of the breast in young women. Clin Dermatol. 1997;15:45–52.PubMedCrossRefGoogle Scholar
  63. 63.
    Moulin G. Superficial papillary adenomatosis of the nipple (with reply). J Am Acad Dermatol. 1997;36:133.PubMedCrossRefGoogle Scholar
  64. 64.
    Adant JP, Paquet P, Bluth F, Nelissen X, Pierard G. Erosive adenomatosis of the nipple. Report of 2 cases. Ann Chir Plast Esthet. 1997;42(6):638–41.PubMedPubMedCentralGoogle Scholar
  65. 65.
    Miller L, Tyler W, Maroon M, Miller OF 3rd. Erosive adenomatosis of the nipple: a benign imitator of malignant breast disease. Cutis. 1997;59(2):91–2.PubMedPubMedCentralGoogle Scholar
  66. 66.
    Kuflik EG. Erosive adenomatosis of the nipple treated with cryosurgery. J Am Acad Dermatol. 1998;38:270–1.PubMedCrossRefGoogle Scholar
  67. 67.
    Van Mierlo PL, Geelen GM, Neumann HA. Mohs micrographic surgery for an erosive adenomatosis of the nipple. Dermatol Surg. 1998;24(6):681–3.PubMedPubMedCentralCrossRefGoogle Scholar
  68. 68.
    Albers SE, Barnard M, Thorner P, Krafchik BR. Erosive adenomatosis of the nipple in an eight-year-old girl. J Am Acad Dermatol. 1999;40(5 Pt 2):834–7.PubMedCrossRefGoogle Scholar
  69. 69.
    Lee HJ, Chug KY. Erosive adenomatosis of the nipple: conservation of the nipple by Mohs micrographic surgery. J Am Acad Dermatol. 2002;47:578–80.PubMedPubMedCentralCrossRefGoogle Scholar
  70. 70.
    Ku BS, Kwon OE, Kim DC, Song KH, Lee CW, Kim KH. A cade of erosive adeno matosis of the nipple treated with total excision using purse-string suture. Dernatol Surg. 2006;32:1093–6.Google Scholar
  71. 71.
    Cosechen MS, Wojcik AS, Piva FM, Werner B, Serafini SZ. Erosive adenomatosis of the nipple. An Bras Dermatol, 2011. 86(4 Suppl 1):S17–20.Google Scholar
  72. 72.
    Kumar PK, Thomas J. Erosive adenomatosis of the nipple masquerading as Paget’s disease. Indian Dermatol Online J. 2013;4(3):239–40.PubMedPubMedCentralCrossRefGoogle Scholar
  73. 73.
    Handley RS, Thackray AC. Adenoma of the nipple. Br J Cancer. 1962;16:187–94.PubMedPubMedCentralCrossRefGoogle Scholar
  74. 74.
    Goldman RL, Cooperman H. Adenoma of the nipple: a benign lesion simulating carcinoma clinically and pathologically. Am J Surg. 1970;119(3):322–5.PubMedCrossRefGoogle Scholar
  75. 75.
    Ferguson MS, Nouraei SA, Davies BJ, McLean NR. Basal cell carcinoma of the nipple-areola complex. Dermatol Surg. 2009;35:1771–5.PubMedCrossRefGoogle Scholar
  76. 76.
    Kurokawa E, Kikkawa N, Taniguchi H. A case of basal cell carcinoma of the nipple and areola with intraductal spread. Breast Cancer. 2001;8(3):229–33.PubMedCrossRefGoogle Scholar
  77. 77.
    Kacerovska D, Michal M, Kazakov DV. Basal cell carcinoma of the nipple extending into the lactiferous duct. Int J Surg Pathol. 2011;19(6):779–80.PubMedPubMedCentralCrossRefGoogle Scholar
  78. 78.
    Moennich J, Ort R, High W, Brown M. Breast carcinoma masquerading as basal cell carcinoma of the nipple. JAAD Case Rep. 2015;1(6):361–3.PubMedPubMedCentralCrossRefGoogle Scholar
  79. 79.
    Wang J, Xiao X, Wang J, Iqbal N, Baxter L, Skinner KA, Hicks DG, Hajdu SI, Tang P. Predictors of nipple-areolar complex involvement by breast carcinoma: histopathologic analysis of 787 consecutive therapeutic mastectomy specimens. Ann Surg Oncol. 2012;19(4):1174–80.PubMedCrossRefGoogle Scholar
  80. 80.
    Robinson HB. Rodent ulcer of the male breast. Trans Pathol Soc Lond. 1893;44:147–8.Google Scholar
  81. 81.
    Farrow JH. Benign and malignant lesions of the nipple. CA Cancer J Clin. 1958;8(1):16–9.PubMedPubMedCentralCrossRefGoogle Scholar
  82. 82.
    Bleehen SS. Pigmented basal cell epithelioma. Light and electron microscopic studies on tumours and cell cultures. Br J Dermatol. 1975;93:361–70.PubMedCrossRefGoogle Scholar
  83. 83.
    Davis AB, Patchefsky AS. Basal cell carcinoma of the nipple: case report and review of the literature. Cancer. 1977;40:1780–1.PubMedPubMedCentralCrossRefGoogle Scholar
  84. 84.
    Tezuka T, Ohkuma M, Hirose I. Melanosomes of pigmented basal cell epithelioma. Dermatologica. 1977;154:14–22.PubMedCrossRefGoogle Scholar
  85. 85.
    Lupton GP, Goeffe DK. Basal cel1 carcinoma of the nipple. Arch Dermatol. 1978;114:1845.PubMedPubMedCentralCrossRefGoogle Scholar
  86. 86.
    Sauven P, Roberts A. Basal cell carcinoma of the nipple. J R Soc Med. 1983;76:699–701.PubMedPubMedCentralCrossRefGoogle Scholar
  87. 87.
    Bruce S, Tschen JA, Goldberg LH. Basal cell carcinoma of the nipple. J Dermatol Surg Oncol. 1985;11:434–5.CrossRefGoogle Scholar
  88. 88.
    Shertz WT, Balogh K. Metastasizing basal cell carcinoma of the nipple. Arch Pathol Lab Med. 1986;110:761–2.PubMedPubMedCentralGoogle Scholar
  89. 89.
    Nirodi NS, Mudd DG. Basal cell carcinoma of the male nipple. J R Coll Surg Edinb. 1986;3l:121–3.Google Scholar
  90. 90.
    Cain RI, Sau P, Benson PM. Basal cell carcinoma of the nipple. Report of two cases. J Am Acad Dermatol. 1990;22:207–10.PubMedPubMedCentralCrossRefGoogle Scholar
  91. 91.
    Benharroch D, Geffen DB, Peiser J, Rosenberg L. Basal cell carcinoma of the male nipple: case report and review of the literature. J Dermatol Surg Oncol. 1993;19(2):137–9.PubMedPubMedCentralCrossRefGoogle Scholar
  92. 92.
    Cooper RA, Eilers DB. Mammographic findings in basal cell carcinoma of the male nipple. Am J Roentgenol. 2000;175(4):1065–6.CrossRefGoogle Scholar
  93. 93.
    Sánchez-Carpintero I, Redondo P, Solano T. Basal cell carcinoma affecting the areola-nipple complex. Plast Reconstr Surg. 2000;105(4):1573.PubMedCrossRefGoogle Scholar
  94. 94.
    Yamamoto H, Ito Y, Hayashi T, Urano N, Kato T, Kimura Y, Tanigawa T, Endo W, Kurokawa E, Kikkawa N, Taniguchi H. A case of basal cell carcinoma of the nipple and areola with intraductal spread. Breast Cancer. 2001;8(3):229–33.PubMedPubMedCentralCrossRefGoogle Scholar
  95. 95.
    Zhu YI, Ratner D. Basal cell carcinoma of the nipple: a case report and review of the literature. Dermatol Surg. 2001;27(11):971–4.PubMedPubMedCentralGoogle Scholar
  96. 96.
    Betti R, Martino P, Moneghini L, Vergani R, Tolomio E, Crosti C. Basal cell carcinomas of the areola-nipple complex: case reports and review of the literature. J Dermatol. 2003;30:822–6.PubMedPubMedCentralCrossRefGoogle Scholar
  97. 97.
    Gupta C, Sheth D, Snower DP. Primary basal carcinoma of the nipple. Arch Pathol Lab Med. 2004;128:792–3.PubMedPubMedCentralGoogle Scholar
  98. 98.
    Huang CW, Pan CK, Juan CC, Shih TF, Tsai CC, Juan CC, Ker CG. Basal cell carcinoma of the nipple-areola complex: a case report. Kaohsiung J Med Sci. 2005;21(10):480–3.PubMedPubMedCentralCrossRefGoogle Scholar
  99. 99.
    Rosen N, Muhn CY, Bernstein SC. A common tumor, an uncommon location: basal cell carcinoma of the nipple and areola in a 49-year-old woman. Dermatol Surg. 2005;31(4):480–3.PubMedPubMedCentralCrossRefGoogle Scholar
  100. 100.
    Chu PY, Teng TH, Lee CC. Primary superficial basal cell carcinoma of the nipple. Ann Saudi Med. 2007;27(4):296–7.PubMedPubMedCentralCrossRefGoogle Scholar
  101. 101.
    Avci O, Pabuççuoĝlu U, Koçdor MA, Unlü M, Akin C, Soyal C, Canda T. Basal cell carcinoma of the nipple—an unusual location in a male patient. J German Soc Dermatol. 2008;6(2):130–2.Google Scholar
  102. 102.
    Ferguson MS, Nouraei SA, Davies BJ, McLean NR. Basal cell carcinoma of the nipple-areola complex. Dermatol Surg. 2009;35:1771–5.PubMedCrossRefGoogle Scholar
  103. 103.
    Oram Y, Demirkesen C, Akkaya AD, Koyuncu E. Basal cell carcinoma of the nipple: an uncommon but ever-increasing location: case reports. Dermatol Med. 2011;2011:81891.Google Scholar
  104. 104.
    Kacerovska D, Michal M, Kazakov DV. Basal cell carcinoma of the nipple extending into the lactiferous duct. Int J Surg Pathol. 2011;19(6):779–80.PubMedPubMedCentralCrossRefGoogle Scholar
  105. 105.
    Jung HJ, Jun JH, Kim HK, Lee SJ, Kim DW, Lee WJ, Jung JH. Pigmented basal cell carcinoma of the nipple-areola complex in an elderly woman. Ann Dermatol. 2011;23(Suppl 2):S201–S4.PubMedPubMedCentralCrossRefGoogle Scholar
  106. 106.
    Sinha AJ, Langtry AA. Secondary intention healing following mohs micrographic surgery for basal cell carcinoma of the nipple and areola. Acta Derm Venereol. 2011;91(1):78–9.PubMedPubMedCentralCrossRefGoogle Scholar
  107. 107.
    Kwasniak LA, Garcia-Zuazaga J. Basal cell carcinoma: evidence-based medicine and review of treatment modalities. Int J Dermatol. 2011;50(6):645–58.PubMedCrossRefGoogle Scholar
  108. 108.
    Sharma A, Tambat RM, Singh A, Dayananda S, Bhalig DS. Basal cell carcinoma of the nipple areola complex. J Midlife Health. 2011;2(2):89–90.PubMedPubMedCentralGoogle Scholar
  109. 109.
    Trignano E, Manzo MJ, Paliogiannis P, Madonia M, Marongiu F, Lissia A, Campus GV. Basal cell carcinoma of the nipple-areola complex: report of a case and literature review. Ann Ital Chir. 2013;84. (ePub) Published online 2013. http://www.academia.edu/8359931/Basal_cell_carcinoma_of_the_nipple-areola_complex
  110. 110.
    Kalvani R, Vani BR, Srinivasm MV, Veda P. Pigmented basal cell carcinoma of nipple and areola in a male breast. Int J Biomed Sci. 2014;10(1):69–72.Google Scholar
  111. 111.
    Akizuki S, Kamei M, Suehiro S, Yamashita S, Kawahara K. Basal cell carcinoma of the nipple in male patients with gastric cancer recurrence: report of a case. Breast Cancer. 2014;21(1):102–7.PubMedCrossRefGoogle Scholar
  112. 112.
    Dewan K, Jash PK, Chattopadhyay D, Saraf A, Np S, Gupta S. Basal cell carcinoma of the nipple: a rare case report. J Dental Med Sci. 2014;13(6):71–2.Google Scholar
  113. 113.
    Bryant T. Diseases of the breast, London 1887:332. In: Deaver JB, McFarland J, Herman L, editors. The breast: its anomalies, its diseases, and their treatment. Philadelphia: P. Blakiston’s Son & Co.; 1917. p. 671–702.Google Scholar
  114. 114.
    Pèraire. Bull et Mém Soc D'Anat de Paris. 1910;LXXV:931. In: Deaver JB, McFarland J, Herman L, editors. The breast: its anomalies, its diseases, and their treatment. Philadelphia: P. Blakiston’s Son & Co.; 1917. p. 671–702.Google Scholar
  115. 115.
    Butlin HT. On the minute anatomy of two cases of carcinoma of the breast preceded by eczema of the nipple and areola. Med Chir Trans. 1877;60:153–160.1.PubMedPubMedCentralCrossRefGoogle Scholar
  116. 116.
    Morris H. On two cases of carcinoma of the breast, preceded by so-called eczema of the nipple and areola. Med Chir Trans. 1880;63:37–50.3.PubMedPubMedCentralCrossRefGoogle Scholar
  117. 117.
    Koretsky L. A case for diagnosis (eczema? carcinoma simplex of the nipple?). Arch Dermatol Syphilol. 1947;55(5):711.CrossRefGoogle Scholar
  118. 118.
    Ah S, El-Nasr HS. A clinical study of eczema of the nipple and areola, and its treatment with oestrogenic hormone. Br J Dermatol Syph. 1949;61(6):216–21.CrossRefGoogle Scholar
  119. 119.
    Farrow JH. Benign and malignant lesions of the nipple. CA Cancer J Clin. 1958;8(1):16–9.PubMedPubMedCentralCrossRefGoogle Scholar
  120. 120.
    Graham DF. Eczema of the nipple. Trans St Johns Hosp Dermatol Soc. 1972;58(1):98–9.PubMedPubMedCentralGoogle Scholar
  121. 121.
    Brackett VH. Eczema of the nipple/areola area. J Hum Lact. 1988;4(4):167–9.PubMedCrossRefGoogle Scholar
  122. 122.
    Amir L. Eczema of the nipple and breast: a case report. J Hum Lact. 1993;9(3):173–5.PubMedCrossRefGoogle Scholar
  123. 123.
    Roumen RM, Haas FD. Eczema of the nipple: cancer or not? Ned Tijdschr Geneeskd. 1997;141(36):1721–4.PubMedPubMedCentralGoogle Scholar
  124. 124.
    Kim DH, Kim CW, Kang SJ, Kim TY. A case of clear cell acanthoma presenting as nipple eczema. Br J Dermatol. 1999;141(5):950–1.CrossRefPubMedGoogle Scholar
  125. 125.
    Barankin B, Gross MS. Nipple and areolar eczema in the breastfeeding woman. J Cutan Med Surg. 2004;8(2):126–30.PubMedCrossRefGoogle Scholar
  126. 126.
    Tougeron D, Wierzbicka-Hainaut E, Osdoit S, Chagneau-Derrode C, Yacoub M, Silvain C. Hyperkeratotic eczema of the nipple and areola associated with sorafenib treatment. Eur J Dermatol. 2010;20(6):854–6.PubMedPubMedCentralGoogle Scholar
  127. 127.
    Kim SK, Won YH, Kim SJ. Nipple eczema: a diagnostic challenge of allergic contact dermatitis. Ann Dermatol. 2014;26(3):413–4.PubMedPubMedCentralCrossRefGoogle Scholar
  128. 128.
    Song HS, Jung SE, Kim YC, Lee ES. Nipple eczema, an indicative manifestation of atopic dermatitis? A clinical, histological, and immunohistochemical study. Am J Dermatopathol. 2015;37(4):284–8.PubMedCrossRefGoogle Scholar
  129. 129.
    Jenkins D, Cooper SM, McPherson T. Unilateral nipple eczema in children: report of five cases and literature review. Pediatr Dermatol. 2015;32(5):718–22.PubMedCrossRefGoogle Scholar
  130. 130.
    Duhn. J Cutaneous Venereal Dis 1886;IV:5. In: Ashhurst J, editor. The international encyclopedia of surgery: a systematic treatise on the theory and practice of surgery. New York: William Wood & Company; 1895. p. 276.Google Scholar
  131. 131.
    Czerny. Epithelioma of breast. Centralblatt f. Chirurgie 1886 Beilage S. 38. In: Ashhurst J, editor. The international encyclopedia of surgery: a systematic treatise on the theory and practice of surgery. New York: William Wood & Company; 1895. p. 276.Google Scholar
  132. 132.
    Curtis BF. Tumors. In: Ashhurst J, editor. The international encyclopedia of surgery: a systematic treatise on the theory and practice of surgery. New York: William Wood & Company; 1895. p. 276.Google Scholar
  133. 133.
    Dennis FS. Diseases of the female breast. In: Dennis FS, Billings JS (eds), System of surgery: tumor, hernia, surgery of the alimentary canal, appendicitis, surgery of the liver and biliary passages, of the uterus, of the ovary and tubes, gynecological surgery, symphysiotomy, surgery of the thyroid, surgical peculiarities of the negro, surgery of the female breast, use of the Röntgen rays in surgery, New York: Lea Brothers & Co.; 1896. p. 871–946.Google Scholar
  134. 134.
    Battle WH, Maybury BC. Primary epithelioma of the nipple in a girl aged eleven. Lancet. 1913;181(4683):1521–2.CrossRefGoogle Scholar
  135. 135.
    Farrow JH. Benign and malignant lesions of the nipple. CA Cancer J Clin. 1958;8(1):16–9.PubMedPubMedCentralCrossRefGoogle Scholar
  136. 136.
    Périn L, Bourdon R, Desprez-Curely JP, Chomé J, Ripault J. Paget’s disease of the nipple and mammary epithelioma. Importance of mammography in diagnosis. Bull Soc Fr Dermatol Syphiligr. 1967;74(3):355–8.PubMedPubMedCentralGoogle Scholar
  137. 137.
    Curtis BF. Tumors. In: Ashhurst J, editor. The international encyclopedia of surgery: a systematic treatise on the theory and practice of surgery. New York: William Wood & Company; 1895. p. 247.Google Scholar
  138. 138.
    Higaki Y, Yoshinaga Y, Kawashima M. Blister formation over a soft fibroma of the nipple. J Dermatol. 1993;20(7):447–8.PubMedPubMedCentralCrossRefGoogle Scholar
  139. 139.
    Gross SW. On the diagnosis of tumours of the mamma. In: Braithwaite W, Braithwaite J, Trevelyen EF, editors. The retrospect of practical medicine. New York: W.A. Townsend; 1881. p. 198–200.Google Scholar
  140. 140.
    Bidder. Fibroma pendulum mammillae. Deutsche Med Wocheschrift. 1884;X:40. In: Deaver JB, McFarland J, Herman L, editors. The breast: its anomalies, its diseases, and their treatment. Philadelphia: P. Blakiston’s Son & Co.; 1917. p. 671–702.Google Scholar
  141. 141.
    Kalischer. Fibroma pendulum mammillae. Berliner Klin Wochenscrrift. 1884;XXI:44. In: Deaver JB, McFarland J, Herman L, editors. The breast: its anomalies, its diseases, and their treatment. Philadelphia: P. Blakiston’s Son & Co.; 1917. p. 671–702.Google Scholar
  142. 142.
    Winckel. Lehrbuch der Freuenkrankheit. 1886:740. In: Deaver JB, McFarland J, Herman L, editors. The breast: its anomalies, its diseases, and their treatment. Philadelphia: P. Blakiston’s Son & Co.; 1917. p. 671–702.Google Scholar
  143. 143.
    Green GD. Lobulated fibroma of the nipple. Trans Path Soc, Londo. 1897–98;XLIX:308. In: Deaver JB, McFarland J, Herman L, editors. The breast: its anomalies, its diseases, and their treatment. Philadelphia: P. Blakiston’s Son & Co.; 1917. p. 671–702.Google Scholar
  144. 144.
    Sheild AM. Pedunculated fibroma of the nipple. Br Med J. 1896;I:1499. In: Deaver JB, McFarland J, Herman L, editors. The breast: its anomalies, its diseases, and their treatment. Philadelphia: P. Blakiston’s Son & Co.; 1917. p. 671–702.Google Scholar
  145. 145.
    Doctor VM, Sirsat MV. Florid papillomatosis (adenoma) and other benign tumours of the nipple and areola. Br J Cancer. 1971;25(1):1–9.PubMedPubMedCentralCrossRefGoogle Scholar
  146. 146.
    Prasad M, Pradhan PK, Bisarya BN. Pedunculated fibroma of nipple. J Indian Med Assoc. 1973;61(12):517.PubMedPubMedCentralGoogle Scholar
  147. 147.
    Nakayama H, Mihara M. Giant pendulous fibroma arising on the areola. Acta Derm Venereol. 1998;78(2):152.PubMedCrossRefGoogle Scholar
  148. 148.
    Parlakgumus A, Yildirim S, Bolat FA, Caliskan K, Ezer A, Colakoglu T, Moray G. Dermatoses of the nipple. Can J Surg. 2009;52(2):160–1.PubMedPubMedCentralGoogle Scholar
  149. 149.
    Seo BF, Jung SN. Fibroma of the nipple. Breast J. 2012;18(5):494–5.PubMedCrossRefGoogle Scholar
  150. 150.
    You HS, Park SM, Cho HH, Kim WJ, Mun JH, Song M, Kim HS, Ko HC, Kim MB, Kim BS. A case of soft fibroma of the nipple with a cauliflower-like appearance. Ann Dermatol. 2015;27(1):102–3.PubMedPubMedCentralCrossRefGoogle Scholar
  151. 151.
    You HS, Park SM, Cho HH, Kim WJ, Mun JH, Song M, Kim HS, Ko HC, Kim MB, Kim BS. A case of soft fibroma of the nipple with a cauliflower-like appearance. Ann Dermatol. 2015;27(1):102–3.PubMedPubMedCentralCrossRefGoogle Scholar
  152. 152.
    Baratelli GM. Pedunculated fibroma of the nipple. http://radiopaedia.org/cases/pedunculated-fibroma-of-the-nipple. Accessed 27 Mar 2016.
  153. 153.
    Castillo M, Sanjuán A, Pérez N, Zanón G, Bons N, Vilanova M, Vanrell JA, Merino MJ, Fernández PL. Fibrous histiocytoma-like spindle-cell proliferation in the nipple after body-piercing. Int J Surg Pathol. 2006;14:89–93.PubMedCrossRefGoogle Scholar
  154. 154.
    Moncorps C. Generalisierte (diffuse) regionare (flachenhafte) und zirkumskripte (solitar, gruppiert oder disseminiert auftretenden) Keratosen. In: Jadassohn J, editor. Handbuch der Haut- und Geschlechtskrankheiten, vol. VIII/2. Berlin: Julius Springer; 1931. p. 281–499.Google Scholar
  155. 155.
    Levy-Frankel A. Les hyperkeratoses de l’areole et du mamelon. Paris Med. 1938;28:63–6.Google Scholar
  156. 156.
    Halter K. Isoliert mamilläre hyperkeratosis follicularis et parafollicularis in cutem penetrans (Kyrle). Arch Derm Syph (Berl). 1938;176:689–93.CrossRefGoogle Scholar
  157. 157.
    Oberste-Lehn H. Hyperkeratosen im Beireich von mamille und areola. Z Haut Geschlechtskr. 1950;8:388–93.PubMedPubMedCentralGoogle Scholar
  158. 158.
    Mehregan AH, Rahbari H. Hyperkeratosis of nipple and areola. Arch Dermatol. 1977;113(12):1691–2.PubMedCrossRefGoogle Scholar
  159. 159.
    Schwartz RA. Hyperkeratosis of nipple and areola. Arch Dermatol. 1978;114(12):1844–5.PubMedCrossRefGoogle Scholar
  160. 160.
    Kim KJ, Cho KH, Kim WS. Hyperkeratosis of nipple and areola: a case report. Korean J Dermatol. 1978;16(6):465–6.Google Scholar
  161. 161.
    Mold DE, Jegasothy BV. Estrogen-induced hyperkeratosis of the nipple. Cutis. 1980;26(1):95–6.PubMedPubMedCentralGoogle Scholar
  162. 162.
    Soden CE. Hyperkeratosis of the nipple and areola. Cutis. 1983;32(1):69–71, 74.PubMedPubMedCentralGoogle Scholar
  163. 163.
    Kuhlman DS, Hodge SJ, Owen LG. Hyperkeratosis of the nipple and areola. J Am Acad Dermatol. 1985;13(4):596–8.PubMedCrossRefGoogle Scholar
  164. 164.
    Vestey JP, Bunney MH. Unilateral hyperkeratosis of the nipple: the response to cryotherapy. Arch Dermatol. 1986;122(12):1360–1.PubMedCrossRefGoogle Scholar
  165. 165.
    Allegue F, Soria C, Rocamora A, Fraile G, Ledo A. Hyperkeratosis of the nipple and areola in a patient with cutaneous T-cell lymphoma. Int J Dermatol. 1990;29(7):519–20.PubMedCrossRefGoogle Scholar
  166. 166.
    Perez-Izquierdo JM, Vilata JJ, Sanchez JL, Gargallo E, Millan F, Aliaga A. Retinoic acid treatment of nipple hyperkeratosis. Arch Dermatol. 1990;126:687–9.PubMedCrossRefGoogle Scholar
  167. 167.
    Ahn SK, Chung J, Soo Lee W, Kim SC, Lee SH. Hyperkeratosis of the nipple and areola simultaneously developing with cutaneous T-cell lymphoma. J Am Acad Dermatol. 1995;32(1):124–5.PubMedCrossRefGoogle Scholar
  168. 168.
    Alpsoy E, Yilmaz E, Aykol A. Hyperkeratosis of the nipple: report of two cases. J Dermatol. 1997;24(1):43–5.PubMedCrossRefGoogle Scholar
  169. 169.
    Obayashi H, Tsuchida T, Ikeda S. Hyperkeratosis of the nipple and areola. Rinsho Dermatol. 1998;40:147–50.Google Scholar
  170. 170.
    Mehanna A, Malak JA, Kibbi AG. Hyperkeratosis of the nipple and areola. Arch Dermatol. 2001;137:1327–8.PubMedCrossRefGoogle Scholar
  171. 171.
    Lambiris AG, McCormick F. Unilateral hyperkeratosis of nipple and areola associated with androgen insensitivity and oestrogen replacement therapy. J Eur Acad Dermatol Venereol. 2001;15(4):376–7.PubMedPubMedCentralGoogle Scholar
  172. 172.
    Lee HW, Suh HS, Choi JC, et al. Hyperkeratosis of the nipple and areola as a sign of malignant acanthosis nigricans. Clin Exp Dermatol. 2005;30(6):721–2.PubMedCrossRefGoogle Scholar
  173. 173.
    Kavak A, Parlak AH, Aydogan I, Alper M. Hyperkeratosis of the nipple and areola in a patient with chronic mucocutaneous candidiasis. J Dermatol. 2006;33(7):510–1.PubMedCrossRefGoogle Scholar
  174. 174.
    Samimi M, Maitre F, Esteve E. Hyperkeratotic lesion of the nipple revealing cutaneous leiomyoma. Ann Dermatol Venereol. 2008;135(8–9):571–4.PubMedCrossRefGoogle Scholar
  175. 175.
    Kartal Durmazlar SP, Eskioglu F, Bodur Z. Hyperkeratosis of the nipple and areola: 2 years of remission with low-dose acitretin and topical calcipotriol therapy. J Dermatolog Treat. 2008;19(6):337–40.PubMedCrossRefGoogle Scholar
  176. 176.
    Higgins HW, Jenkins J, Horn TD, Kroumpouzos G. Pregnancy-associated hyperkeratosis of the nipple: a report of 25 cases. JAMA Dermatol. 2013;l4(6):722–6.CrossRefGoogle Scholar
  177. 177.
    Martinez-Garcia E, Taibjee S, Koch D, Osborne R. Vemurafenib-induced hyperkeratosis of the areola treated with topical adapalene. Clin Exp Dermatol. 2015;41(2):148–51.PubMedCrossRefGoogle Scholar
  178. 178.
    Friolet H. Ichthyosis Circumscripta of the areola mammae. Münch Med Wochenschr. 1905;LII:1818.Google Scholar
  179. 179.
    Bulman JFH. Leiomyoma of nipple. Br Med J. 1951;2(4737):975. In: Deaver JB, McFarland J, Herman L, editors. The breast: its anomalies, its diseases, and their treatment. Philadelphia: P. Blakiston’s Son & Co.; 1917. p. 671–702.Google Scholar
  180. 180.
    Nascimento AG, Karas M, Rosen PP, Caron AG. Leiomyoma of the nipple. Am J Surg Pathol. 1979;3(2):151–4.PubMedCrossRefGoogle Scholar
  181. 181.
    Virchow R. Uber cavernose (erektile) Geschwulste und Teleangiektasien. Virchows Arch Pathol Anat. 1854;6:525–4. In: Deaver JB, McFarland J, Herman L, editors. The breast: its anomalies, its diseases, and their treatment. Philadelphia: P. Blakiston’s Son & Co.; 1917. p. 671–702.Google Scholar
  182. 182.
    Klob. Path Anat der Weiblichen Sexorgane 1864. In: Deaver JB, McFarland J, Herman L, editors. The breast: its anomalies, its diseases, and their treatment. Philadelphia: P. Blakiston’s Son & Co.; 1917. p. 671–702.Google Scholar
  183. 183.
    Solokov. Virchow’s Archiv. 1873;LVIII:336. In: Deaver JB, McFarland J, Herman L, editors. The breast: its anomalies, its diseases, and their treatment. Philadelphia: P. Blakiston’s Son & Co.; 1917. p. 671–702.Google Scholar
  184. 184.
    Tsujioka K, Klashihara M, Imamura S. Cutaneous leiomyoma of the male nipple. Dermatologica. 1985;170:98–100.PubMedCrossRefGoogle Scholar
  185. 185.
    Allison JG, Dodds HM. Leiomyoma of the male nipple. A case report and literature review. Am Surg. 1989;55(8):501–2.PubMedPubMedCentralGoogle Scholar
  186. 186.
    Pujol RM, Fernandez MT. A solitary papule on the nipple. Arch Dermatol. 1991;127:571–6.CrossRefGoogle Scholar
  187. 187.
    Velasco M, Ubeda B, Antonell F, Serra C. Leiomyoma of the male areola infiltrating the breast tissue. Am J Roentgenol. 1995;164(22):511–2.CrossRefGoogle Scholar
  188. 188.
    Kaufman HL, Hirsch EF. Leiomyoma of the breast. J Surg Oncol. 1996;62:62–4.PubMedPubMedCentralCrossRefGoogle Scholar
  189. 189.
    Haier J, Haensch W, Schon M. Leiomyoma as a rare differential diagnosis of Paget’s disease of the nipple. Act Obstet Gynecolog Scaand. 1997;76(5):490–1.CrossRefGoogle Scholar
  190. 190.
    Roustan G, Sanchez E, Ruiz P, Simon A. Leiomioma de la areola mamaria. Presentación de dos casos. Actas Dermosifiliogr. 2001;92:35–7.CrossRefGoogle Scholar
  191. 191.
    Chaudhary KS, Shousha S. Leiomyoma of the nipple, and normal subareolar muscle fibres, are oestrogen and progesterone receptor positive. Histopathology. 2004;44(6):626–8.CrossRefPubMedGoogle Scholar
  192. 192.
    Khachemoune A, Rodriguez C, Lyle S, Jiang SB. Genital leiomyoma: surgical excision for both diagnosis and treatment of a unilateral leiomyoma of the male nipple. Dermatol Online J. 2005;11(1):20.PubMedPubMedCentralGoogle Scholar
  193. 193.
    Ku J, Campbell C, Bennett I. Leiomyoma of the nipple. Breast J. 2006;12(4):377–80.PubMedPubMedCentralCrossRefGoogle Scholar
  194. 194.
    Shibata S, Imafuky S, Tashiro A, Gondo CH, Toyoshima S, Furue M. Leiomyoma of the male nipple. J Dermatol. 2011;38:727–9.PubMedCrossRefGoogle Scholar
  195. 195.
    Leaño CD, María Garritano MV, Tobares N, Rafti P, Pianzola H. Leiomioma solitario en el complejo areola pezón. A propósito de un caso. Revisión de la literatura. Arch Argent Dermatol. 2011;61:203–8.Google Scholar
  196. 196.
    Cho HJI, Km SH, Kang BJ, Kim H, Song BJ, Lee AW. Leiomyoma of the nipple diagnosed by MRI. Acta Radiolog Short Rep. 2012;1(9):4.Google Scholar
  197. 197.
    Nakamura S, Hashimoto Y, Takeda K, Nishi K, Ishida-Yamamoto A, Mizumoto T, Lizuka H. Two cases of male nipple leiomyoma: idiopathic leiomyoma and gynecomastia-associated leiomyoma. Am J Dermatopathol. 2012;34(3):287–91.PubMedPubMedCentralCrossRefGoogle Scholar
  198. 198.
    Lòpez V, Lòpez I, Alcaccer J, Ricart JM. Successful treatment of leiomyoma of the nipple with carbon dioxide laser. Acta Dermosifilogr. 2013;104(10):928–30.CrossRefGoogle Scholar
  199. 199.
    Pavlidis L, Vakirlis E, Spyropoulou GA, Pramateftakis MG, Dionyssiou D, Demiri E. A 35-year-old woman presenting with an unusual post-traumatic leiomyoma of the nipple. J Med Case Rep. 2013;7:49.PubMedPubMedCentralCrossRefGoogle Scholar
  200. 200.
    Hernandez FJ. Leiomyosarcoma of male breast originating in the nipple. Am J Surg Pathol. 1978;2(3):299–304.PubMedCrossRefGoogle Scholar
  201. 201.
    Luh SP, Wong LC, Huang PC, Luh SP, Huang CS. Primary leiomyosarcoma of the nipple-areola complex: report of a case and review of literature. J Zhejiang Univ Sci B. 2008;9(2):109–13.PubMedPubMedCentralCrossRefGoogle Scholar
  202. 202.
    Lonsdale RN, Widdison A. Leiomyosarcoma of the nipple. Histopathology. 1992;20(6):537–9.PubMedCrossRefGoogle Scholar
  203. 203.
    Liang WC, Sickle-Santanello BJ, Nims TA, Accetta PA. Primary leiomyosarcoma of the breast: a case report with review of the literature. Breast J. 2003;9(6)(6):494.CrossRefGoogle Scholar
  204. 204.
    Samimi M, Maître F, Estève E. Hyperkeratotic lesion of the nipple revealing cutaneous leiomyoma. Ann Dermatol Venereol. 2008;135(8–9):571–4.PubMedCrossRefGoogle Scholar
  205. 205.
    Wong LC, Huang PC, Luh SP, Huang CS. Primary leiomyosarcoma of the nipple-areola complex: report of a case and review of literature. J Zhejiang Univ Sci B. 2008;9(2):109–13.PubMedPubMedCentralCrossRefGoogle Scholar
  206. 206.
    Kamio T, Nishizawa M, Aoyama K, Ohchi T, Nishikawa T, Kobayashi M, Kameoka S. Primary leiomyosarcoma of the breast treated by partial resection of the breast including nipple and areola: report of a case. Surg Today. 2010;40(11):1063–7.PubMedCrossRefGoogle Scholar
  207. 207.
    Deveci U, Kapakli MSX, Altintoprak F, Cayirci MX, Manukyan MN, Kebudi A. Bilateral nipple leiomyomas. Case Rep Surg. 2013;2013(2013):475215.PubMedPubMedCentralGoogle Scholar
  208. 208.
    Guedes X, Matarde M, Parra T, Martinez MJ, de Caralt E, Serra C. Primary leiomyosarcoma of the nipple-areola complex with an unusual clinical presentation: a case report. IJCRI. 2014;5(1):66–70.CrossRefGoogle Scholar
  209. 209.
    Skin-melanocytic tumor. http://pathologyoutlines.com/topic/skintumormelanocteicsuperpage.html. Accessed 4 Apr 2016.
  210. 210.
    Papachristou DN, Kinne D, Ashikari R, Fortner JG. Melanoma of the nipple and areola. Br J Surq. 1979;66(4):287–8.CrossRefGoogle Scholar
  211. 211.
    Kinoshita S, Yoshimoto K, Kyoda S, Hirano A, Shioya H, Kobayashi S, Ishiji T, Komine K, Takeyama H, Uchida K, Morikawa T, Sakamoto G. Malignant melanoma originating on the female nipple: a case report. Breast Cancer. 2007;14(1):105–8.PubMedCrossRefGoogle Scholar
  212. 212.
    Jensen AK. Melanoma of the nipple. Arch Dermatol Syphilol. 1947;56(1):113.CrossRefGoogle Scholar
  213. 213.
    Farrow JH. Benign and malignant lesions of the nipple. CA Cancer J Clin. 1958;8(1):16–9.PubMedPubMedCentralCrossRefGoogle Scholar
  214. 214.
    Kuten A, Cohen Y, Kerner V. Malignant melanoma of the nipple with autoamputation of the breast. Harefuah. 1976;90(7):321–2.PubMedPubMedCentralGoogle Scholar
  215. 215.
    D’Aiuto G, Del Vecchio S, Mansi L, D’Aprile M, Botti G, Salvatore M. Malignant melanoma of the nipple: a case studied with radiolabeled monoclonal antibody. Tumori. 1991;77(5):449–51.PubMedCrossRefGoogle Scholar
  216. 216.
    Carmichael AR, McIntyre M, Chetty U. Malignant melanoma in accessory nipple in a male. J Coll Physicians Surg Pak. 2006;16(12):799–800.PubMedPubMedCentralGoogle Scholar
  217. 217.
    Lin CH, Lee HS, Yul JC. Melanoma of the nipple mimicking Paget’s disease. Dermatol Online J. 2007;13(2):18.PubMedPubMedCentralGoogle Scholar
  218. 218.
    Mourmouras V, Ambrosio MR, Onorati M, Rocca BJ, Di Mari N, De Luca F, Miracco C. Melanoma of the nipple. An additional case. Pathologica. 2011;103(1):25–6.PubMedPubMedCentralGoogle Scholar
  219. 219.
    Srikanth S, Anandam G. Malignant melanoma of male breast with nodal metastasis. Case report. Med J Dr DY Patil Univ. 2014;7(2):192–4.CrossRefGoogle Scholar
  220. 220.
    He Y, Mou JH, Luo D, Gao B, Wen Y. Primary malignant melanoma of the breast: a case report and review of the literature. Oncol Lett. 2014;8(1):238–40.PubMedPubMedCentralCrossRefGoogle Scholar
  221. 221.
    Shiga K, Oiso N, Narita T, Kimura M, Kawada A. Dermoscopy for malignant melanoma of the nipple and the areola. J Dermatol. 2015;42(3):339–41.PubMedCrossRefGoogle Scholar
  222. 222.
    Sills M, Norton S, Landers R, O’Donoghue G. Malignant melanoma of the breast: a case report. J Cancer Biol Res. 2016;4(1):1075.Google Scholar
  223. 223.
    Folberg R, McLean IW. Primary aquired melanosis and melanoma of the conjunctive: terminology, classificaion, and biologic behavior. Mod Pathol. 1986;17:652–4.Google Scholar
  224. 224.
    Isbary G, Coras-Stepanek B, Stolz W. Pigmented lesion of the left nipple in a 49-year-old woman. J Dtsch Dermatol Ges. 2013;11(12):1206–8.PubMedPubMedCentralGoogle Scholar
  225. 225.
    Sceppa JA, Smith BL, Marghoob AA, Gottlieb GJ. Melanosis of the areola and nipple. J Am Acad Dermatol. 2008;59(2 Suppl 1):S33–4.PubMedCrossRefGoogle Scholar
  226. 226.
    Huerta-Brogeras M, Garrido-Ríos A, Borbujo J, Tardío JC. Unilateral hyperpigmented lesion of the breast in a young woman. Melanosis of the areola and nipple. JAMA Dermatol. 2013;149(3):357–63.PubMedCrossRefGoogle Scholar
  227. 227.
    Isbary G, Coras-Stepanek B, Dyall-Smith D, Guther S, Tillmann A, Stolz W. Five patients with melanosis of the nipple and areola clinically mimicking melanoma. J Eur Acad Dermatol Venereol. 2014;28(9):1251–4.PubMedCrossRefGoogle Scholar
  228. 228.
    Antonov NK, Bosenberg MW, Halasz CL. Melanosis of the areola and nipple with an atypical pigment network. Int J Dermatol. 2015;55:811–3.PubMedCrossRefGoogle Scholar
  229. 229.
    Hoyt BS, Tschen JA, Cohen PR. Molluscum contagiosum of the areola and nipple: case report and literature review. Dermatol Online J. 2013;19(7):18965.PubMedGoogle Scholar
  230. 230.
    Heath. Lancet, London. 1872;i:603. In: Deaver JB, McFarland J, Herman L, editors. The breast: its anomalies, its diseases, and their treatment. Philadelphia: P. Blakiston’s Son & Co.; 1917. p. 671–702.Google Scholar
  231. 231.
    Klauber. Prager Med Wochenschrift. 1904;XXIX,65:663. In: Deaver JB, McFarland J, Herman L, editors. The breast: its anomalies, its diseases, and their treatment. Philadelphia: P. Blakiston’s Son & Co.; 1917. p. 671–702.Google Scholar
  232. 232.
    Carvalho G. Molluscum contagiosum in a lesion adjacent to the nipple. Report of a case. Acta Cytol. 1974;18(6):532–4.PubMedGoogle Scholar
  233. 233.
    Kumar N, Okiro P, Wasike R. Cytological diagnosis of molluscum contagiosum with an unusual clinical presentation at an unusual site. J Dermatol Case Rep. 2010;4(4):63–5.PubMedPubMedCentralGoogle Scholar
  234. 234.
    Likhar KS, Hazari RA, Gupta SG, Patle Y. Isolated molluscum contagiosum of nipple: a rare case study. J Evolution Med Dental Sci. 2014;3(28):7696–700.CrossRefGoogle Scholar
  235. 235.
    Caroppo D, Natella V, Scalvenzi M, Vetrani A, Cozzolino I. Molluscum contagiosum diagnosis on nipple scraping sample. Breast J. 2016;22(1):120–1.PubMedPubMedCentralCrossRefGoogle Scholar
  236. 236.
    Friedrich RE, Hage C. Appendices of the nipple and areola of the breast in neurofibromatosis type 1 patients are neurofibroma. Anticancer Res. 2010;30(5):1815–7.PubMedPubMedCentralGoogle Scholar
  237. 237.
    Zhou Y, Pan B, Mao F, Zhu Q, Huo Z, Wang H, Cai F, Liang Z, Wang C, Zhang Y, Sun Q. A hidden breast lump covered by nipple appendices in a patient with von Recklinghausen disease: a case report and review of the literature. Clinl Breast Cancer. 2012;12(1):71–5.CrossRefGoogle Scholar
  238. 238.
    Sherman JE, Smith JW. Neurofibromas of the breast and nipple-areolar area. Ann Plast Surg. 1981;7(4):302–7.PubMedCrossRefGoogle Scholar
  239. 239.
    Lima RO, Stefenon CC. Neurofibroma de mama. Rev Bras Mastol. 2000;10(2):100–2.Google Scholar
  240. 240.
    Lannon DA, Harris PA, Butler PE. Treatment of severe neurofibromatosis of the nipple-areola complex. Plast Reconstr Surg. 2003;111(2):952–3.PubMedCrossRefGoogle Scholar
  241. 241.
    Murat A, Kansiz F, Kabakus N, Kazez A, Ozercan R. Neurofibroma of the breast in a boy with neurofibromatosis type 1. Clin Imaging. 2004;28:415–7.PubMedCrossRefGoogle Scholar
  242. 242.
    Millman SL, Mercado CL. An unusual presentation of neurofibromatosis of the breast. Breast J. 2004;10(1):45–7.PubMedCrossRefGoogle Scholar
  243. 243.
    Posada JG, Chakmakjian CG. Images in clinical medicine. Von Recklinghausen’s disease and breast cancer. N Engl J Med. 2005;352(17):1799.PubMedCrossRefGoogle Scholar
  244. 244.
    Gokalp G, Hakyemez B, Kizilkaya E, Haholu A. Myxoid neurofibromas of the breast: mammographical, sonographical and MRI appearances. Br J Radiol. 2007;80:e234–7.PubMedCrossRefGoogle Scholar
  245. 245.
    Tostes RO, Chagas LN, Guedes JCC, Quinsan MP, Avellán LJV, Costa JM. Nipple-areolar complex neurofibromas: case report. Rev Bras Cirurg Plast. 2007;22(2):122–5.Google Scholar
  246. 246.
    An HY, Kim KY, Yu IK, Kim KW, Kim HH. The nipple-areolar complex: a pictorial review of common and uncommon conditions. J Ultrasound Med. 2010;29:949–62.PubMedCrossRefGoogle Scholar
  247. 247.
    Friedrich RE, Hage C. Appendices of the nipple and areola of the breast in neurofibromatosis type 1 patients are neurofibroma. Anticancer Res. 2010;30(5):1815–7.PubMedPubMedCentralGoogle Scholar
  248. 248.
    Bongiorno MR, Doukaki S, Aricò M. Neurofibromatosis of the nipple-areolar area: a case series. J Med Case Rep. 2010;4:22.PubMedPubMedCentralCrossRefGoogle Scholar
  249. 249.
    Goksugur N, Gurel S. Neurofibromatosis of nipple-areola complex. Breast J. 2011;17(4):424.PubMedCrossRefGoogle Scholar
  250. 250.
    Spyropoulou GA, Pavlidis L, Trakatelli M, Athanasiou E, Pazarli E, Sotiriadis D, Demiri E. Rare benign tumours of the nipple. J Eur Acad Dermatol Venereol. 2015;29(1):7–13.PubMedCrossRefGoogle Scholar
  251. 251.
    Cunha Filho RR, Almeida HLJ, Cartell A. Verrucous epidermal nevus manifesting as nipple and areola hyperkeratosis. An Bras Dermatol. 2006;81(4):377–9.CrossRefGoogle Scholar
  252. 252.
    Urbani CE, Betti R. Supernumerary nipple in association with Becker nevus vs. Becker nevus syndrome: a semantic problem only. Am J Med Genet. 1998;77(1):76–7.PubMedCrossRefGoogle Scholar
  253. 253.
    Lewis EJ, Crutchfield CE 3rd, Ebertz MJ, Prawer SE. Report of a nipple nevus and an overview of accessory mammary tissue. Cutis. 1998;62(5):243–6.PubMedGoogle Scholar
  254. 254.
    Xifra M, Lagodin C, Wright D, Abbruzzese M, Woscoff A. Nevoid keratosis of the nipple. J Am Acad Dermatol. 1999;41:325–6.PubMedCrossRefGoogle Scholar
  255. 255.
    Mehanna A, Malak JA, Kibbi A-G, Büyükbabani N, Kavak A, Murat A. Nevoid hyperkeratosis of nipple and areola: a distinct entity. J Am Acad Dermatol. 2002;46:414–8.CrossRefGoogle Scholar
  256. 256.
    Krishnan RS, Angel TA, Roark TR, Hsu S. Nevoid hyper keratosis of the nipple and/or areola: a report of two cases and a review of the literature. Int J Dermatol. 2002;41:775–7.PubMedCrossRefGoogle Scholar
  257. 257.
    Baykal C, Biiyiikbabani N, Kavak A, Alper M. Nevoid hyperkeratosis of the nipple and areola: a distinct entity. Am Acad Dermatol. 2002;46(3):414–8.CrossRefGoogle Scholar
  258. 258.
    Baz K, Kokturk A, Kaya TI, Ikizoglu G, Düsmez D, Koca A. A case of hyperkeratosis of the nipple and areola resulting from organoid nevus. Int J Dermatol. 2003;42:318–20.PubMedCrossRefGoogle Scholar
  259. 259.
    Pastar Z, Massone C, Ahlgrimm-Siess V, Koller S, Mofarrah R, Hofmann-Wellenhof R. Dermoscopy and in vivo reflectance confocal microscopy of a congenital nevus of the nipple. Dermatology. 2010;221(2):127–30.PubMedPubMedCentralGoogle Scholar
  260. 260.
    Verma P, Pandhi D, Yadav P. Unilateral nevoid/primary hyperkeratosis of nipple and areola successfully treated with radiofrequency ablation. Cutan Aesthet Surg. 2011;4(3):214–5.CrossRefGoogle Scholar
  261. 261.
    Yikilmaz ŞR, Wilson-Clay B. Successful breastfeeding outcome of a woman with a nevus of the nipple: a case study. J Hum Lact. 2016;32:361–3.PubMedCrossRefGoogle Scholar
  262. 262.
    Sanati S, Leonard M, Khamapirad T, Eltorky MA. Nodular mucinosis of the breast: a case report with pathologic, ultrasonographic, and clinical findings and review of the literature. Arch Pathol Lab Med. 2005;129(3):e58–61.PubMedPubMedCentralGoogle Scholar
  263. 263.
    Kempf W, von Stumberg B, Denisjuk N, Bode B, Rongioletti F. Trauma-induced cutaneous focal mucinosis of the mammary areola: an unusual presentation. Dermatopathology. 2014;1:24–8.PubMedPubMedCentralCrossRefGoogle Scholar
  264. 264.
    Vázquez-Doval FJ, Sola MA. Mucinosis of the mammary areolae and mycosis fungoides. Clin Exp Dermatol. 1996;21:374–6.PubMedCrossRefGoogle Scholar
  265. 265.
    Michal M, Ludvikova M, Zamecnik M. Nodular mucinosis of the breast: report of three cases. Pathol Int. 1998;48:542–4.PubMedCrossRefGoogle Scholar
  266. 266.
    Koide N, Akashi-Tanaka S, Fukutomi T, Nanasawa T, Hasegawa T. Nodular mucinosis of the breast: a case report with clinical and imaging findings. Breast Cancer. 2002;9:261–4.PubMedCrossRefGoogle Scholar
  267. 267.
    Manglik N, Berlingeri-Ramos AC, Boroumand N, Eltorky M. Nodular mucinosis of the breast in a supernumerary nipple: case report and review of the literature. J Cutan Pathol. 2010;37(11):1178–81.PubMedCrossRefGoogle Scholar
  268. 268.
    Fernández-Figueras MT, Kazakov DV, López Martos R, Ojanguren I, Vila J, Ariza A. Nodular mucinosis of the breast in a male: reassessment of diagnostic criteria and proposal for its classification as a soft tissue tumor in the myofibroblastoma and spindle cell lipoma spectrum. Dermatopathology. 2014;1:47–54.PubMedPubMedCentralCrossRefGoogle Scholar
  269. 269.
    Paget JY. St. Barttholew’s Hosp Rep., London. 1874;X:87–9. In: Deaver JB, McFarland J, Herman L, editors. The breast: its anomalies, its diseases, and their treatment. Philadelphia: P. Blakiston’s Son & Co.; 1917. p. 671–702.Google Scholar
  270. 270.
    Butlin. Medico-Chirurgical Transactions, London. 1876;IX:107. In: Deaver JB, McFarland J, Herman L, editors. The breast: its anomalies, its diseases, and their treatment. Philadelphia: P. Blakiston’s Son & Co.; 1917. p. 671–702.Google Scholar
  271. 271.
    Thin. Trans Path Soc of London. 1881;XXXII:218. In: Deaver JB, McFarland J, Herman L, editors. The breast: its anomalies, its diseases, and their treatment. Philadelphia: P. Blakiston’s Son & Co.; 1917. p. 671–702.Google Scholar
  272. 272.
    Duhring. Am J Med Sci. 1883;LXXXVI:116. In: Deaver JB, McFarland J, Herman L, editors. The breast: its anomalies, its diseases, and their treatment. Philadelphia: P. Blakiston’s Son & Co.; 1917. p. 671–702.Google Scholar
  273. 273.
    Wile. Am J Med Sci. 1884;LXXXVIII:141. In: Deaver JB, McFarland J, Herman L, editors. The breast: its anomalies, its diseases, and their treatment. Philadelphia: P. Blakiston's Son & Co.; 1917. p. 671–702.Google Scholar
  274. 274.
    Bowlby. Medico-Chirurgical Transactions, London. 1890–91;LXXIV:341. In: Deaver JB, McFarland J, Herman L, editors. The breast: its anomalies, its diseases, and their treatment. Philadelphia: P. Blakiston's Son & Co.; 1917. p. 671–702.Google Scholar
  275. 275.
    Bowlby AA. Thirteen cases of Paget’s disease of the nipple, with special reference to the causation of the malady by psorosperms. Med Chir Trans. 1891;74:341–366.1.PubMedPubMedCentralCrossRefGoogle Scholar
  276. 276.
    O’Neill H. Report of a case of Paget’s disease of the right nipple. Br Med J. 1891;1(1581):846–8.PubMedPubMedCentralCrossRefGoogle Scholar
  277. 277.
    Karg. Deutsche Zeitschrift für Chirurgie. 1892;XXXIV. In: Deaver JB, McFarland J, Herman L, editors. The breast: its anomalies, its diseases, and their treatment. Philadelphia: P. Blakiston’s Son & Co.; 1917. p. 671–702.Google Scholar
  278. 278.
    Evans W. Paget’s disease. Proc R Soc Med. 1909;2(Dermatol Sect):162.PubMedPubMedCentralGoogle Scholar
  279. 279.
    Davis H. Paget’s disease of the nipple. Proc R Soc Med. 1913;6(Dermatol Sect):5.PubMedPubMedCentralGoogle Scholar
  280. 280.
    Bunch JL. Paget’s disease of the nipple. Proc R Soc Med. 1914;7(Dermatol Sect):255–7.PubMedPubMedCentralGoogle Scholar
  281. 281.
    Jopson JH, Speese J. Paget’s disease of the nipple and allied conditions. Ann Surg. 1915;62(2):212–37.PubMedPubMedCentralCrossRefGoogle Scholar
  282. 282.
    Sekiguchi S. Studies on Paget’s disease of the nipple and its extramammary occurrence: reports of eighteen cases personally investigated. Ann Surg. 1917;65(2):175–98.PubMedPubMedCentralCrossRefGoogle Scholar
  283. 283.
    Gabriel WB. Case of Paget’s disease. Proc R Soc Med. 1926;19(Surg Sect):14.PubMedPubMedCentralGoogle Scholar
  284. 284.
    Little EG. Ulceration of nipple: Paget’s disease. Proc R Soc Med. 1928;21(7):1177.PubMedPubMedCentralGoogle Scholar
  285. 285.
    Cheatle L. Paget’s disease of the nipple. Proc R Soc Med. 1930;23(4):550.PubMedPubMedCentralGoogle Scholar
  286. 286.
    Gardham AJ. Early Paget’s disease of the nipple, with an extensive carcinoma of the breast. Proc R Soc Med. 1931;24(6):779.PubMedPubMedCentralGoogle Scholar
  287. 287.
    Barber HW. Paget's disease of the nipple associated with diffuse carcinomatosis of the chest wall. Proc R Soc Med. 1932;25(5):670–2.PubMedPubMedCentralGoogle Scholar
  288. 288.
    Bamber G. Intra-epidermal carcinoma. Paget’s disease of the nipple. Proc R Soc Med. 1933;26(7):841.PubMedPubMedCentralGoogle Scholar
  289. 289.
    West JP, Nickel WF. Paget’s disease of the nipple. Ann Surg. 1942;116(1):19–25.PubMedPubMedCentralCrossRefGoogle Scholar
  290. 290.
    Inglis K. Paget’s disease of the nipple: with special reference to the changes in the ducts. Am J Pathol. 1946;22(1):1–33.PubMedPubMedCentralGoogle Scholar
  291. 291.
    Costello MJ. Paget’s disease of the nipple. Arch Dermatol Syphilol. 1946;54:110.CrossRefGoogle Scholar
  292. 292.
    Allen H, Stout AP. Carcinoma of breast with Paget’s disease. Mo Med. 1947;44(8):584.PubMedPubMedCentralGoogle Scholar
  293. 293.
    Wagner M. Report of a case of Paget’s disease in an 18 year old male, with a review of the literature. Wis Med J. 1947;46(11):1098–107.PubMedPubMedCentralGoogle Scholar
  294. 294.
    Setala K. Paget’s disease of the nipple with special reference to its relation of dermal gland carcinomata. Acta Pathol Microbiol Scand. 1949;26(2):207–22.PubMedCrossRefGoogle Scholar
  295. 295.
    Marx R. Significance of ductal sclerosis in Paget’s disease; regression of intraductal carcinoma. Arch Pathol (Chic). 1949;47(4):404–6.Google Scholar
  296. 296.
    Clymer JH, Halpert B, et al. Paget’s disease of the nipple. J Okla State Med Assoc. 1949;42(9):393–6.PubMedPubMedCentralGoogle Scholar
  297. 297.
    Tzanck. Paget’s disease of the nipple. Ann Dermatol Syphiligr (Paris). 1950;10(5):opp 545.Google Scholar
  298. 298.
    Jonquieres EJ, Grillo A, Melamed AJ. Paget’s disease of the nipple; therapeutic considerations. Sem Med. 1950;57(42):800–4.PubMedPubMedCentralGoogle Scholar
  299. 299.
    Eisen MJ, Taft RH. Cytological diagnosis of mammary cancer associated with incipient Paget’s disease of the nipple. Cancer. 1951;4(1):150–3.PubMedCrossRefGoogle Scholar
  300. 300.
    Michalany J. Carcinoma of the breast and Paget’s disease of the nipple. Hospital (Rio J). 1951;39(1):81–94.Google Scholar
  301. 301.
    Dockerty MB, Harrington SW. Preclinical Paget’s disease of the nipple. Surg Gynecol Obstet. 1951;93(3):317–20.PubMedPubMedCentralGoogle Scholar
  302. 302.
    Oddo R, Martin-Laval J. Degenerated Paget’s disease of the nipple in pregnancy. Bull Fed Soc Gynecol Obstet Lang Fr. 1952;4(5):963–4.PubMedPubMedCentralGoogle Scholar
  303. 303.
    Johnson N. Paget’s disease of the nipple. Aust N Z J Surg. 1952;22(2):111–9.PubMedCrossRefGoogle Scholar
  304. 304.
    Veronesi U, Rabotti G. Cytological diagnosis of Paget’s disease of the nipple. Tumori. 1954;40(2):204–12.PubMedCrossRefGoogle Scholar
  305. 305.
    Culberson JD, Horn RC Jr. Paget’s disease of the nipple; review of twenty-five cases with special reference to melanin pigmentation of Paget cells. AMA Arch Surg. 1956;72(2):224–31.PubMedCrossRefGoogle Scholar
  306. 306.
    Helman P, Kliman M. Paget's disease of the nipple; a clinical review of 27 cases. Br J Surg. 1956;43(181):481–8.PubMedCrossRefGoogle Scholar
  307. 307.
    Devine JW, Devine JW Jr, Thornhill TM. Paget’s disease of the nipple. Va Med Mon (1918). 1956;83(7):303–4.Google Scholar
  308. 308.
    Farrow JH. Benign and malignant lesions of the nipple. CA Cancer J Clin. 1958;8(1):16–9.PubMedPubMedCentralCrossRefGoogle Scholar
  309. 309.
    Wiman LG, Skogh M. Cytodiagnosis of Paget’s disease of the nipple. Some reflections on a case with negative biopsy. Sven Lakartidn. 1960;57:3154–8 passim.PubMedPubMedCentralGoogle Scholar
  310. 310.
    Toker C. Some observations on Paget’s disease of the nipple. Cancer. 1961;14:653–72.PubMedCrossRefGoogle Scholar
  311. 311.
    Carcassonne F, Temime P, Bonneau H. A case of Paget’s disease strictly localized in the nipple. Cytological and histological study. Bull Soc Fr Dermatol Syphiligr. 1962;69:133–4.PubMedPubMedCentralGoogle Scholar
  312. 312.
    Orr JW, Parish DJ. The nature of the nipple changes in Paget’s disease. J Pathol Bacteriol. 1962;84:201–8.PubMedCrossRefGoogle Scholar
  313. 313.
    Rogers J. Paget’s disease of the nipple. Br J Clin Pract. 1962;16:813.PubMedPubMedCentralGoogle Scholar
  314. 314.
    Aboumrad MH, Horn RC Jr, Fine G. Lipid-secreting mammary carcinoma. Report of a case associated with Paget's disease of the nipple. Cancer. 1963;16:521–5.PubMedCrossRefGoogle Scholar
  315. 315.
    Greenwood SM, Minkowitz S. Paget’s disease in metastatic breast carcinoma. Arch Dermatol. 1971;104(3):312–5.PubMedCrossRefGoogle Scholar
  316. 316.
    Sugimoto M, Matsushima T, Ando M, Tsuda T, Ozaki T. Unusual pulmonary metastasis of mammary cancer: unilateral pulmonary fibrosis after mammary Paget’s disease. Kumamoto Med J. 1974;27(3):176–82.PubMedPubMedCentralGoogle Scholar
  317. 317.
    Dabski K, Stoll HL Jr. Paget’s disease of the breast presenting as a cutaneous horn. J Surg Oncol. 1985;29:237–9.PubMedCrossRefGoogle Scholar
  318. 318.
    Menon RS, van Geel AN. Cancer of the breast with nipple involvement. J Cancer. 1989;59(1):81–4.CrossRefGoogle Scholar
  319. 319.
    Tousignant J, Grossin M, Crickx B, Belaïch S. Paget’s disease of the nipple associated with epidermal basaloid hyperplasia simulating basal cell carcinoma. Ann Dermatol Venereol. 1991;118(3):211–4.PubMedPubMedCentralGoogle Scholar
  320. 320.
    Roumen RM, Haas FD. Eczema of the nipple: cancer or not? Ned Tijdschr Geneeskd. 1997;141(36):1721–4.PubMedPubMedCentralGoogle Scholar
  321. 321.
    Fu W, Mittel VK, Young SC. Paget disease of the breast: analysis of 41 patients. Am J Clin Oncol. 2001;24:397–400.PubMedCrossRefGoogle Scholar
  322. 322.
    Frei KA, Bonel HM, Pelte MF, Hylton NM, Kinkel K. Paget disease of the breast: findings at magnetic resonance imaging and histopathologic correlation. Investig Radiol. 2005;40:363–7.CrossRefGoogle Scholar
  323. 323.
    Amano G, Yajima M, Moroboshi Y, Kuriya Y, Ohuchi N. MRI accurately depicts underlying DCIS in a patient with Paget’s disease of the breast without palpable mass and mammography findings. Jpn J Clin Oncol. 2005;35:149–53.PubMedCrossRefGoogle Scholar
  324. 324.
    Mitchell ML, Napoletano J, Penman EJ. The MRI appearance of Paget’s disease of the nipple: images from a single case. Del Med J. 2006;78:105–6.PubMedPubMedCentralGoogle Scholar
  325. 325.
    Gunhan-Bilgen I, Oktay A. Paget’s disease of the breast: clinical, mammographic, sonographic and pathologic findings in 52 cases. Eur J Radiol. 2006;60:256–63.PubMedCrossRefGoogle Scholar
  326. 326.
    Betal D, Puri N, Roberts K, Kalra L, Rapisarda F, Bonomi R. Hyperpigmented Paget’s disease of the nipple - a diagnostic dilemma. JRSM Short Rep. 2012;3(5):31.PubMedPubMedCentralCrossRefGoogle Scholar
  327. 327.
    Challa VR, Deshmane V. Challenges in diagnosis and management of Paget’s disease of the breast—a retrospective study. Indian J Surg. 2015;77(Suppl 3):1083–7.PubMedCrossRefGoogle Scholar
  328. 328.
    Akita M, Kusunoki N, Nakajima T, Takase S, Maekawa Y, Kajimoto K, Ohno M. Paget’s disease of the male breast: a case report. Surg Case Rep. 2015;1(1):103.PubMedPubMedCentralCrossRefGoogle Scholar
  329. 329.
    Challa VR, Deshmane V. Challenges in diagnosis and management of paget’s disease of the breast-a retrospective study. Indian J Surg. 2015;77(Suppl 3):1083–7.PubMedCrossRefGoogle Scholar
  330. 330.
    Dennis MA, Parker S, Kaske TI, Stavros AT, Camp J. Incidental treatment of nipple discharge caused by benign intraductal papilloma through diagnostic mammotome biopsy. Am J Roentgenol. 2000;174(5):1263–8.CrossRefGoogle Scholar
  331. 331.
    Reverdin. Tumeur papillaire pedunculée de l'areola du sein. Bull et Mém de la Soc d’Anat de Paris. 1867;XLII:540. In: Deaver JB, McFarland J, Herman L, editors. The breast: its anomalies, its diseases, and their treatment. Philadelphia: P. Blakiston’s Son & Co.; 1917. p. 671–702.Google Scholar
  332. 332.
    Shaw. Tumor attached by a pedicle to the areola of the left breast. Trans Pathological Soc London. 1850–51;III:186. In: Deaver JB, McFarland J, Herman L, editors. The breast: its anomalies, its diseases, and their treatment. Philadelphia: P. Blakiston’s Son & Co.; 1917. p. 671–702.Google Scholar
  333. 333.
    Porter FT. Erectile tumor of the nipple. Irish Hospital Gazette, Dublin. 1873;I:30. In: Deaver JB, McFarland J, Herman L, editors. The breast: its anomalies, its diseases, and their treatment. Philadelphia: P. Blakiston’s Son & Co.; 1917. p. 671–702.Google Scholar
  334. 334.
    Pollard. Trans Path Soc Lond 1886;XXV. In: Deaver JB, McFarland J, Herman L, editors. The breast: its anomalies, its diseases, and their treatment. Philadelphia: P. Blakiston’s Son & Co.; 1917. p. 671–702.Google Scholar
  335. 335.
    Robinson. Cystic papilloma of the nipple. Trans Path Soc., London. 1890;XLI. In: Deaver JB, McFarland J, Herman L, editors. The breast: its anomalies, its diseases, and their treatment. Philadelphia: P. Blakiston’s Son & Co.; 1917. p. 671–702.Google Scholar
  336. 336.
    Linfors. Monatschrift für Geburtshülft Gynäkologie. 1900;XI:763. In: Deaver JB, McFarland J, Herman L, editors. The breast: its anomalies, its diseases, and their treatment. Philadelphia: P. Blakiston’s Son & Co.; 1917. p. 671–702.Google Scholar
  337. 337.
    Salzac E. Papillomas cutanées de mamelon. Thèse Paris 1903. In: Deaver JB, McFarland J, Herman L, editors. The breast: its anomalies, its diseases, and their treatment. Philadelphia: P. Blakiston’s Son & Co.; 1917. p. 671–702.Google Scholar
  338. 338.
    Negri L. Uncommon cases of mammary pathology. 1. Acute diffuse superficial phlegmon. 2. Papilloma of the male nipple. 3. Epidermoid cysts. 4. Infantile mammary fibroma. 5. Fibrosarcoma. Arch De Vecchi Anat Patol. 1951;16(3):1247–64.PubMedPubMedCentralGoogle Scholar
  339. 339.
    Farrow JH. Benign and malignant lesions of the nipple. CA Cancer J Clin. 1958;8(1):16–9.PubMedPubMedCentralCrossRefGoogle Scholar
  340. 340.
    Ferlito A. On intraductal papilloma of the nipple in the male breast. Riv Anat Patol Oncol. 1969;35:339–44.PubMedPubMedCentralGoogle Scholar
  341. 341.
    Innocenti P, Ucchino S, Cianchetti E, Basilico L, Angelone A. Papilloma of the nipple. General remarks and comment apropos of a personal case. Minerva Chir. 1976;31(19):1089–94.PubMedPubMedCentralGoogle Scholar
  342. 342.
    Keswani NK, Gupta SC. Unusual case of squamous papilloma of nipple. J Indian Med Assoc. 1979;72(4):83–4.PubMedPubMedCentralGoogle Scholar
  343. 343.
    Manavi M, Baghestanian M, Kucera E, Berger A, Schatten C, Pischinger K, Czerwenka K. Papilloma virus and c-erbB-2 expression in diseases of the mammary nipple. Anticancer Res. 2001;21(1B):797–801.PubMedPubMedCentralGoogle Scholar
  344. 344.
    Wei H, Jiayi F, Qinping Z, Junyi S, Yuan S, Li L, Dongwei S, Liying Q. Ultrasound-guided vacuum-assisted breast biopsy system for diagnosis and minimally invasive excision of intraductal papilloma without nipple discharge. World J Surg. 2009;33(12):2579–81.PubMedCrossRefGoogle Scholar
  345. 345.
    Singh A, Nigam JS, Misra V, Singh PA. Diagnosis of a nonpalpable intraductal papilloma without radiological abnormality by nipple discharge smear examination: a case report. Breast Cancer (Auckl). 2014;8:69–72.Google Scholar
  346. 346.
    Kleb. Handbuch der Pathologgisch Anatomie. 1876;I,2:1225. In: Deaver JB, McFarland J, Herman L, editors. The breast: its anomalies, its diseases, and their treatment. Philadelphia: P. Blakiston's Son & Co.; 1917. p. 671–702.Google Scholar
  347. 347.
    Gross SW. On the diagnosis of tumours of the mamma. In: Braithwaite W, Braithwaite J, Trevelyen EF, editors. The retrospect of practical medicine. New York: W.A. Townsend; 1881. p. 198–200.Google Scholar
  348. 348.
    Fruhling L, Le Gall Y. Six cases of genuine primitive sarcoma of the nipple. Bull Fed Soc Gynecol Obstet Lang Fr. 1952;4(3):565–6.PubMedPubMedCentralGoogle Scholar
  349. 349.
    Kopacz A, Kucharski A, Cicholska A, Jaśkiewicz J. Reticulum cell sarcoma of the nipple. Nowotwory. 1979;29(2):121–3.PubMedPubMedCentralGoogle Scholar
  350. 350.
    Shamsadini S, Wadji MB, Shamsadini A. Surrounding ipsilateral eruptive seborrheic keratosis as a warning sign of intraductal breast carcinoma and Paget’s disease (Leser Trelat sign). Dermatol Online J. 2006;12:27.PubMedPubMedCentralGoogle Scholar
  351. 351.
    Schwartz RA. Sign of Leser-Trélat. J Am Acad Dermatol. 1996;35(1):88–95.PubMedCrossRefGoogle Scholar
  352. 352.
    Leser E. Ueber ein die Krebskrankheit beim Menschen haufig begleitendes, noch wenig gekanntes Symptom. Munchener Med Wochenschr. 1901;51:2035–6.Google Scholar
  353. 353.
    Hollander EV. Beitrage zur Fruhdiagnose des Darmcarcinomas (Hereditatsverhaltnisse und Hautveranderungen). Deutsche Medicinische Wochenschrift. 1900;26:483–5.CrossRefGoogle Scholar
  354. 354.
    De Morgan C. On the origin of cancer. Lancet. 1871;II:6–7, 41–42.Google Scholar
  355. 355.
    Narasimha A, Harendra Kumar ML, Divyarani MN, Bhaskaran A. Pigmented seborrheic keratosis (melanoacanthoma) of nipple: a case report with review of literature. J Clin Biomed Sci. 2013;3(2):96–100.Google Scholar
  356. 356.
    Mckee PH, Calonje E, Grant SR. Pathology of skin with clinical correlation. 3rd ed. Philadelphia: Elsevier Mosby; 2005. p. 1158–63.Google Scholar
  357. 357.
    Mullikan JB. Capillary malformations, hyperkeratotic stains, telangiectasis, and miscellaneous vascular blots. In: Mulliken JB, Burrows PE, Fishman SJ, editors. Mulliken and Young’s vascular anomalies: hemangiomas and malformations. Oxford: Oxford University Press; 2013. p. 508–61.CrossRefGoogle Scholar
  358. 358.
    Mandry G. Primäres carcinom der Brustwartze. Beiträge zur Klinischen Chirurgie, Tübingen 1893;X:231. In: Deaver JB, McFarland J, Herman L, editors. The breast: its anomalies, its diseases, and their treatment. Philadelphia: P. Blakiston’s Son & Co.; 1917. p. 671–702.Google Scholar
  359. 359.
    Loveland-Jones CE, Wang F, Bankhead RR, Huang Y, Reilly KJ. Squamous cell carcinoma of the nipple following radiation therapy for ductal carcinoma in situ: a case report. J Med Case Rep. 2010;4:186.PubMedPubMedCentralCrossRefGoogle Scholar
  360. 360.
    Upasham SP, VinodKiri M, Sudhamani S. One more common tumor in an uncommon location: Squamous cell carcinoma on nipple areola complex. Indian J Cancer. 2014;51(3):376–7.PubMedCrossRefGoogle Scholar
  361. 361.
    Brodie B. Lecture on pathology and surgery, London 1846. In: Deaver JB, McFarland J, Herman L, editors. The breast: its anomalies, its diseases, and their treatment. Philadelphia: P. Blakiston’s Son & Co.; 1917. p. 671–702.Google Scholar
  362. 362.
    Kroell H. Praktischer Arzt Wetzler. 1878;XIX, 25:40. In: Deaver JB, McFarland J, Herman L, editors. The breast: its anomalies, its diseases, and their treatment. Philadelphia: P. Blakiston’s Son & Co.; 1917. p. 671–702.Google Scholar
  363. 363.
    D’Alger B. Bull et Mém Soc de Chirurgie de Paris. 1885. In: Deaver JB, McFarland J, Herman L, editors. The breast: its anomalies, its diseases, and their treatment. Philadelphia: P. Blakiston’s Son & Co.; 1917. p. 671–702.Google Scholar
  364. 364.
    Weil J. Prage Med Wocheschrift 1893;XVIII:81. In: Deaver JB, McFarland J, Herman L, editors. The breast: its anomalies, its diseases, and their treatment. Philadelphia: P. Blakiston’s Son & Co.; 1917. p. 671–702.Google Scholar
  365. 365.
    Morestin H. Bull et Mèm de la Soc de Paris. 1907:LXXXXII:608. In: Deaver JB, McFarland J, Herman L, editors. The breast: its anomalies, its diseases, and their treatment. Philadelphia: P. Blakiston’s Son & Co.; 1917. p. 671–702.Google Scholar
  366. 366.
    Battle and Mayberry. Lancet, London. 1913;I:22. In: Deaver JB, McFarland J, Herman L, editors. The breast: its anomalies, its diseases, and their treatment. Philadelphia: P. Blakiston’s Son & Co.; 1917. p. 671–702.Google Scholar
  367. 367.
    Edwards MJ, Hirsch RM, Broadwater JR, Netscher DT, Ames FC. Squamous cell carcinoma arising in previously burned or irradiated skin. Arch Surg. 1989;124:115–7.PubMedCrossRefGoogle Scholar
  368. 368.
    Van Hoeven KH, Drudis T, Cranor ML, Erlandson RA, Rosen PP. Low-grade adenosquamous carcinoma of the breast: a clinicopathologic study of 32 cases with ultrastructural analysis. Am J Surg Pathol. 1993;17(3):248–58.PubMedCrossRefGoogle Scholar
  369. 369.
    Venkataseshan VS, Budd DC, Kim DU, Hutter RVP. Intraepidermal squamous carcinoma (Bowen’s disease) of the nipple. Hum Pathol. 1994;25(12):l371–4.CrossRefGoogle Scholar
  370. 370.
    Uzoaru I, Adeyanju M, Ray VH, Nadimpalli V. Primary squamous cell carcinoma of the breast presenting as a nipple discharge. Acta Cytol. 1994;38(1):112–3.PubMedPubMedCentralGoogle Scholar
  371. 371.
    Brookes PT, Jhawar S, Hinton CP, Murdoch S, Usman T. Bowen’s disease of the nipple—a new method of treatment. Breast. 2005;14(1):65–7.PubMedCrossRefGoogle Scholar
  372. 372.
    Brookes PT, Jhawar S, Hinton CP, Murdoch S, Usman T. Bowen’s disease of the nipple—a new method of treatment. Breast. 2005;14:65–7.PubMedCrossRefGoogle Scholar
  373. 373.
    Sharma R, Iyer M. Bowen’s disease of the nipple in a young man with AIDS: a case report. Clin Breast Cancer. 2009;9(l):53–5.PubMedCrossRefGoogle Scholar
  374. 374.
    Chen CH, Rowlands C, Sengupta SK, George RL, Parulekar W, Thain K, O’Malley F, Isotalo PA. Primary basaloid carcinoma of the nipple with associated squamous cell carcinoma in situ. Breast J. 2009;15(4):409–13.PubMedCrossRefGoogle Scholar
  375. 375.
    Hosaka N, Uesaka K, Takaki T, Zhang Y, Takasu K, Ikehara S. Poorly differentiated squamous cell carcinoma of the nipple: a unique case for marked exophytic growth, but little invasion with neuroendocrine differentiation. Med Mol Morphol. 2011;44(3):174–8.PubMedPubMedCentralCrossRefGoogle Scholar
  376. 376.
    King F, Kremer H. Squamous cell carcinoma of the nipple: an unusual location in a male patient. Am Surg. 2012;78(2):El01–E2.Google Scholar
  377. 377.
    Sofos SS, Tehrani H, Lymperopoulos N, Constantinides J, James MI. Primary squamous cell carcinoma of the nipple: a diagnosis of suspicion. J Plast Reconstr Aesthet Surg. 2013;66(11):e315–7.PubMedCrossRefGoogle Scholar
  378. 378.
    Upasham SP, Vinodkiri M, Sudhamani S. One more common tumor in an uncommon location: squamous cell carcinoma on nipple areola complex. Indian J Cancer. 2014;51(3):376–7.PubMedCrossRefGoogle Scholar
  379. 379.
    Pendse AA, O'Connor SM. Primary invasive squamous cell carcinoma of the nipple. Case Rep Pathol. 2015;2015:327487.PubMedPubMedCentralGoogle Scholar
  380. 380.
    Congdon G, Dockerty M. Malignant lesions of the nipple exclusive of Paget’s disease. Surg Gynecol Obstet. 1956;103:185–92.PubMedPubMedCentralGoogle Scholar
  381. 381.
    Fernández-Jorge B, Yebra-Pimentel T. Nódulo solitario en la areola mamaria de un varón. Piel. 2007;22:353–4.CrossRefGoogle Scholar

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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Private PracticeTustinUSA

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