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An Ensemble Approach for Gene Selection in Gene Expression Data

  • José A. Castellanos-GarzónEmail author
  • Juan Ramos
  • Daniel López-Sánchez
  • Juan F. de Paz
Conference paper
  • 637 Downloads
Part of the Advances in Intelligent Systems and Computing book series (AISC, volume 616)

Abstract

Feature/Gene selection is a major research area in the study of gene expression data, generally dealing with classification tasks of diseases or subtype of diseases and identification of biomarkers related to a type of disease. In such a context, this paper proposes an ensemble approach of gene selection for classification tasks from gene expression datasets. This proposal provides a four-staged approach of gene filtering. Each stage performs a different gene filtering task, such as: data processing, noise removing, gene selection ensemble and application of wrapper methods to reach the end result, a small subset of informative genes. Our proposal has been assessed on two different datasets of the same disease (Pancreatic ductal adenocarcinoma) for which, good results have been achieved in comparison with other gene selection methods. Hence, the proposed strategy has proven its reliability with respect to other approaches.

Keywords

DNA-microarray Gene expression data Feature/Gene selection Ensemble method Wrapper method Filter method 

Notes

Acknowledgments

This work has been supported by project MOVIURBAN: Máquina social para la gestión sostenible de ciudades inteligentes: movilidad urbana, datos abiertos, sensores móviles. SA070U 16. Project co-financed with Junta Castilla y León, Consejería de Educación and FEDER funds.

The research of Daniel López-Sánchez has been financed by the Ministry of Education, Culture and Sports of the Spanish Government (University Faculty Training (FPU) program, reference number FPU15/02339).

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • José A. Castellanos-Garzón
    • 1
    • 2
    Email author
  • Juan Ramos
    • 1
  • Daniel López-Sánchez
    • 1
  • Juan F. de Paz
    • 1
  1. 1.IBSAL/BISITE Research Group, Edificio I+D+i USALUniversity of SalamancaSalamancaSpain
  2. 2.CISUC, ECOS Research Group, Pólo II - Pinhal de MarrocosUniversity of CoimbraCoimbraPortugal

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