GER and Antacid Medications

  • Jose M. Garza
  • Carlo Di LorenzoEmail author


Gastric acid secretion is a physiological process essential for food digestion. It is regulated by paracrine, hormonal, and neural pathways. Antacids, surface-protective agents, and antisecretory agents are used for treating gastroesophageal reflux disease (GER). Antacids are helpful for immediate symptomatic relief but are not recommended for chronic use. Histamine-2 receptor antagonists have a role in the management of episodic and mild symptoms, particularly for infrequent GER or reflux-related symptoms. Proton pump inhibitors (PPIs) have become some of the most frequently prescribed medications in both children and adults, and their effectiveness for treatment of peptic conditions in the pediatric population has been established. They are well tolerated in both infants and children, but as with any other pharmacologic therapy, PPIs are not exempt of side effects, and risk-benefit should be assessed in individual cases, especially when a chronic use is necessary.


Acid Parietal cell Gastrin Antacid Surface-protecting agents Sucralfate Alginates Parietal cell Proton pump inhibitors H2 receptor antagonists H2 blockers 


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© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Children’s Center for Digestive HealthcareAtlantaUSA
  2. 2.Neurogastroenterology and MotilityChildren’s Healthcare of AtlantaAtlantaUSA
  3. 3.PediatricsThe Ohio State UniversityColumbusUSA
  4. 4.Division of Pediatric GastroenterologyNationwide Children’s HospitalColumbusUSA

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